sexual orientation

From quantum physics to quantum souls (4)

The long-range consequences of food energy-dependent social factors predictably link everything known about social odors called pheromones from the quantized energy in food to metabolism and biophysically constrained viral latency.  Sympatric speciation exemplifies what is known about how quantized energy links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency in species from microbes to humans. In this review of biophysically constrained viral latency and biodiversity, I linked energy-dependent changes from angstroms to ecosystems in the mouse-to-human model of microRNA-mediated amino…

Read More

Abiogenesis vs microRNA biogenesis (3)

Reappraising the human mitochondrial DNA recombination dogma   My comment to BioRxiv (Hold on, this is waiting to be approved by BioRxiv) Thank you for helping to show what has been missing from neo-Darwinian theories and other claims that were based on de Vries 1902 definition of mutation. Theorists may now want to learn more about the energy-dependent molecular mechanisms of recombination. Most of them will not like the findings you have provided. The peer-review process is especially deadly to…

Read More

Polymaths and paradigm shifts: from Asimov to Bear (4)

Saying Goodbye to the RNA World Theory RNA has a limited ability for catalysis compared to peptides, and would have struggled to maintain its catalytic activity under the changing temperature conditions of early Earth. Carter and Wills also argued that if an RNA world existed, it would have been unlikely for it to incorporate peptides later on. See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)…

Read More

The overwhelming ignorance of sex researchers (2)

Conclusion: There is a clear link from Estrogen receptor α polymorphism in individuals and in species with differences in behavioral phenotypes. The differences are food energy-dependent and RNA-mediated. The differences link the sense of smell and the pheromone-controlled physiology of reproduction in soil bacteria from The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression to the report on the Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys Reported…

Read More

The overwhelming ignorance of sex researchers

Summary: J. Michael Bailey, and others like him, pretend to not know how non-coding variants are epigenetically linked from differences in hydrogen bonds to all energy-dependent biophysically constrained morphological and behavioral phenotypes. Genome-Wide Association Study of Male Sexual Orientation [Energy-dependent changes in biophysically constrained viral latency] We identified several [energy-dependent changes in] SNPs with p < 10−5, including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 × 10−7) and 14 (p = 4.7 × 10−7). The genes nearest to these peaks have functions plausibly relevant to…

Read More

Energy-dependent epigenetic translation to mRNA stability

Negative selection in humans and fruit flies involves synergistic epistasis Negative selection against deleterious alleles produced by mutation influences within-population variation as the most pervasive form of natural selection. Naturally occurring positive selection for energy-dependent codon optimality replaced every aspect of neo-Darwinian theories that linked natural selection from mutations to evolution of increasing organismal complexity. Positive selection for epigenetically-effected beneficial alleles links the epigenetic landscape to the physical landscape of supercoiled DNA via nutrient-dependent pheromone-controlled metabolic networks and genetic networks.…

Read More

Antithetical conclusions (4)

Evidence for sex-specific genetic architectures across a spectrum of human complex traits …will need to disentangle whether sex genetic heterogeneity may arise as a consequence of interactions with genetic loci located on the sex chromosomes, differences in gene control due to differences in the sex-specific cellular environment, or more general differences in environmental exposures between the sexes. Nutrient energy-dependent pheromone-controlled sex differences in the cell types of species from yeasts to humans link changes in the microRNA/messenger RNA balance and…

Read More

MicroRNAs and sexual orientation

A neural circuit encoding sexual preference in humans Excerpt: We anticipate the identification of a core neural circuit for sexual preferences to be a starting point for further sophisticated investigations into the neural principles of sexual behavior and particularly of its aberrations. My comment: They link sexual orientation in yeasts to humans but fail to recognize the fact that it is nutrient energy-dependent and pheromone-controlled by RNA methylation, the innate immune system, and supercoiled DNA. 20 years after we published…

Read More

Selective reporting of inferences: examples of pseudoscience

In the narrative of this presentation on RNA mediated molecular epigenetics and virus driven entropy, I mentioned that Cori Bargmann is scheduled to deliver a lecture entitled “Genes, neurons, circuits and behavior: an integrated approach in a compact brain.” An integrated approach will help others understand what is currently known about how ecological variation leads to ecological adaptation. Works, like hers, with the nematode model organism will help others understand how ecological adaptation leads to biodiversity in the morphological phenotypes…

Read More

Organic Compounds and the Miracle of Smell and Taste

Neo-Darwian evolutionary theorists and human ethologists seem to ignore the fact that reproductive isolation is nutrient-dependent and controlled by the physiology of reproduction. …reproductive isolation may sometimes follow and at other times precede the adaptive divergence of gene pools of populations. — Dobzhansky (1972) Those who cite Dobzhansky’s (1973)  claim that Nothing in Biology Makes Any Sense Except in the Light of Evolution, have failed to explain why …the so-called alpha chains of hemoglobin have identical sequences of amino acids…

Read More