single amino acid substitution

Viruses in pathogenic variants disrupt alternative splicings

Pathogenic variants that alter protein code often disrupt splicing Approximately 10% of exonic mutations altered splicing, mostly by disrupting multiple stages of spliceosome assembly. We present a large-scale characterization of exonic splicing mutations using a new technology that facilitates variant classification and keeps pace with variant discovery. Assay of nearly 5,000 mutations reveals roots of genetic splicing errors “Splicing errors can be very deleterious because instead of just changing one amino acid [the building block of a protein], it can…

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Proof: Sunlight is energy as information

Hypothesis: Kallmann’s syndrome is proof that virus-driven energy theft causes all pathology in species from archaea to humans via the degradation of messenger RNA and the loss of one allele.   Thought experiment: Step 1) The loss of one allele and the transgenerational epigenetic inheritance of Zika virus-damaged DNA can be compared to the degradation of messenger RNA in bacteria that is manifested in archaea and L-forms. Step 2) The degradation of messenger RNA in primates differentiates healthy longevity from…

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Virus altered thermodynamic stability

Mechanisms of Zika Virus Infection and Neuropathogenesis and Flavivirus infection requires specific host genes Excerpt: The researchers identified 9 genes that… are associated with the cell’s endoplasmic reticulum, where viral translation, replication, and assembly of viral particles takes place. Six of the genes also reduced infection of Zika, dengue, Japanese encephalitis, and yellow fever viruses when removed from human cells. Most showed similar effects when absent from insect cells tested for West Nile and dengue virus infections. My comment: They…

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