small RNAs

Abiogenesis vs microRNA biogenesis

Summary: The pseudoscientific nonsense about abiogenesis that has been touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories. See for comparison: Structural diversity of supercoiled DNA and the parody from the same research group: ——————————- Abiogenesis (2017) Microscopic dissipative structuring and proliferation at the origin of life (Oct 13, 2017) Some fundamental molecules…

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The MicroRNAome Strikes Back: A Sokalian hoax (1)

Summary: How can this not be a Sokalian hoax? The creation of sunlight is not linked to anti-entropic virucidal energy-dependent  cell-type-specific epigenetic modifications. The quantized energy-dependent epigenetic modifications include RNA-directed DNA methylation, histone modification, nucleosome remodeling and higher-order chromatin reorganization. Instead, the magic of non-cell autonomous DNA methylation in plants is placed into in the context of the cytosine residue in CG, CHG and CHH sequence contexts (where H represents A, T or C). See for comparison: Analysis of 6,515 exomes reveals…

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Robert Sapolsky’s legacy of atheistic pseudoscientific nonsense

Summary: Not only does everything known to serious scientists about energy link RNA synthesis to life, everything McEwen and others have published links nutrient stress and/or social stress to the virus-driven degradation of messenger RNA and all pathology. As moderator of the International Society for Human Ethology (ISHE), a not-for-profit scientific organization that consistently touts pseudoscientific nonsense in the context of neo-Darwinian evolution, Jay R. Feierman’s attacks on the works of serous scientists are increasing in frequency and in magnitude.…

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Did “Nature” kill Steve Jobs? (3)

So Many Research Scientists, So Few Openings as Professors Excerpt: Even someone as brilliant as Emmanuelle Charpentier, who in 2015 became head of the Max Planck Institute for Infection Biology after a momentous discovery in gene editing, spent the previous 25 years moving through nine institutions in five countries. My comment: Why did she move around so much when in the same year, on 07/02/2015, George Church and colleagues filed a patent application for “RNA-Guided Human Genome Engineering.” Excerpt: Repetitive…

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A two-faced protein enables RNA-mediated DNA repair (2)

A two-faced protein enables RNA-mediated DNA repair See also: Abundant contribution of short tandem repeats to gene expression variation in humans (subscription required) Excerpt: …suggesting that STRs have a key role in the evolution of expression. Indeed, several candidate gene studies in humans reported that STR variations modulate gene expression19,33–37 and alternative splicing… Reported as:  Researchers find repetitive DNA provides a hidden layer of functional information Excerpt:  He is calling these variants eSTRs, or expression STRs, to note that they…

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Teaching the biologically uninformed

Stark Reality by Todd I. Stark: Computer consultant, science writer, avid reader, martial arts enthusiast. My favorite discussion topics are cognitive neuroscience, psychology, biology, problem solving, human performance, and Microsoft SharePoint technologies. Fatness and Obesity: Framing the Problem Excerpt: …we have to understand what about our lives is most mismatched with our ability to regulate our energy storage. Is it the sorts of things we are eating? The activities we engage in? The nutritional quality available to us? The amount…

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Origin of life and cancer (1,2,3)

1) On the Origins of Life The physics of the light-induced de novo creation of the amino acids was placed into the context of  ‘cyanosulfidic’ protometabolic systems chemistry. The systems chemistry links substitution of achiral glycine in the gonadotropin releasing hormone (GnRH) decapeptide to the biophysically constrained nutrient dependent RNA-mediated chemistry of protein folding in all vertebrates. The role of food odors and hormone-controlled cell type differentiation in all vertebrates also links changes in the balance of viral microRNAs and…

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Biologists puzzled by evolved RNAs and decaying DNA

Horizontal Transfer of Entire Genomes via Mitochondrial Fusion in the Angiosperm Amborella (December, 2013) Excerpt) “The ancestral angiosperm-wide genome duplication apparent in the Amborella genome not only serves as a genetic marker for the origin of extant angiosperms, but it may also have set in motion a series of events as numerous genes evolved novel functions, eventually leading to modern flowering plants.” See also: The Amborella Genome and the Evolution of Flowering Plants Excerpt) “Evolution of Small RNAs More than…

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