social

Environmental selection is natural selection

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk was published on April 23, 2018 The ectodysplasin A receptor (EDAR) gene has a range of pleiotropic effects, including sweat gland density, incisor shoveling, and mammary gland ductal branching. The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to…

Read More

Polymaths and paradigm shifts: from Asimov to Bear (4)

Saying Goodbye to the RNA World Theory RNA has a limited ability for catalysis compared to peptides, and would have struggled to maintain its catalytic activity under the changing temperature conditions of early Earth. Carter and Wills also argued that if an RNA world existed, it would have been unlikely for it to incorporate peptides later on. See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)…

Read More

Vulgar Antagonists vs Quantum Effects

Exosome Cargo Could Be Drug Target For Neuropathic Pain My discussion attempt was removed by Dfm Prime, who claims to be a patient advocate for those who are suffering from neurological insult. See: Works at Neurosensory Neuroregenerative Research Foundation Publication: Catechol-O-Methyl Transferase Inhibition Reduces Symptoms of Hallucinogen Persisting Perception Disorder See for comparison: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults In my model, fluoroquinolone use to kill gut bacteria sometimes kills the bacteria that…

Read More

New Testament Book Cover Refutes Theistic Evolution

Video of Biology of the Book Goats, bookworms, a monk’s kiss: Biologists reveal the hidden history of ancient gospels Collins already had developed a method to identify ancient species by differences in the amino acid sequences of collagen and other proteins preserved in fossils. See: Protein power by Robert F. Service …methods to sequence amino acids lag behind DNA sequencing. The report of 300 million year old proteins is based on ridiculous theories that failed to include what was known about…

Read More

Energy-dependent physical and biophysical constraints (5)

Summary: Emmy Noethe’s theorems were developed in the early 1900’s. Richard Feynman inadvertently or purposefully alluded to them as examples of human idiocy. Discover Magazine resurrected the examples of human idiocy in a 2017 article. For comparison, Choi et al., (2017) support the claims that intercellular and interkingdom communication is energy-dependent and controlled by the metabolism of food energy to pheromones. It is obvious that pheromones biophysically constrain the virus-driven degradation of messenger RNA. That fact links everything currently known…

Read More

Energy-dependent hydrogen bonds in supercoiled DNA

Chirality Check Most biological macromolecules are homochiral, and enzymes help to maintain this state of affairs; for example, checkpoints ensure that only l-amino acids are incorporated into proteins during translation. The fixation of the only achiral amino acid, glycine in position 6 of the gonadotropin releasing hormone decapeptide protein links the nutrient energy-dependent pheromone-controlled physiology of reproduction from yeasts to humans. That fact about RNA-mediated protein folding chemistry is missing from the chirality check, It also is missing from representations…

Read More

Model vs theory: Progress report!

On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to…

Read More

Life history transitions and RNA-mediated survial

The Endospore-Forming Pathogen Bacillus cereus Exploits a Small Colony Variant-Based Diversification Strategy in Response to Aminoglycoside Exposure Conclusion:  Thus, consideration of SCVs as a new, yet unexplored lifestyle of B. cereus within the common ecological niches, in which antibiotic-active substances produced by competitive microorganisms, plants, and invertebrate/vertebrate vectors might potentially also induce this persistent life-form of B. cereus, opens a panoply of research questions to be followed up. Reported as: Lifestyle switching – Bacillus cereus is able to resist certain antibiotic therapies…

Read More

Researchers rename, reshuffle, and reveal their ignorance

New Species Abound Re: Researchers renamed, reshuffled, and revealed species… Evidently, NEW SPECIES is part of a misleading headline placed into the context of some that EMERGED. Adapted/updated from my comments on Beyond DNA See: A Cellular System for Spatial Signal Decoding in Chemical Gradients This cellular system links the sun’s anti-entropic force and the virucidal effect of UV light to the strategic cellular defense system of all cell types. Researchers began studying this particular molecule because the RNA kicks…

Read More

Cell type differentiation: atoms to ecosystems

Relaxed genetic control of cortical organization in human brains compared with chimpanzees Abstract conclusion: A major result of increased plasticity is that the development of neural circuits that underlie behavior is shaped by the environmental, social, and cultural context more intensively in humans than in other primate species, thus providing an anatomical basis for behavioral and cognitive evolution. Reported as: Nature and nurture: Human brains evolved to be more responsive to environmental influences Excerpt: …the morphology of the human cerebral…

Read More