socio-cognitive niche construction

Can protein folding chemistry be understood by theorists?

Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular function, “but the nuances of biology rest in how individual isoforms are regulated,” Aye said. Natural selection for energy-dependent codon optimality regulates the creation of…

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Energy-dependent physical and biophysical constraints (5)

Summary: Emmy Noethe’s theorems were developed in the early 1900’s. Richard Feynman inadvertently or purposefully alluded to them as examples of human idiocy. Discover Magazine resurrected the examples of human idiocy in a 2017 article. For comparison, Choi et al., (2017) support the claims that intercellular and interkingdom communication is energy-dependent and controlled by the metabolism of food energy to pheromones. It is obvious that pheromones biophysically constrain the virus-driven degradation of messenger RNA. That fact links everything currently known…

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Energy-dependent oscillating gene networks organize life

Nascent, innate, intrinsic, and biofunctional are among the “weasel words” used by theorists who ignore the fact that all life-sustaining energy comes from the sun via hydrogen-atom transfer in DNA base pairs in solution. See how Jon Lieff continues to misrepresent that fact, by placing everything known about RNA-mediated cell type differentiation back into the context of evolution. Like all pseudoscientists, he starts with energy but fails to mention where the energy came from or where it goes when virus-driven…

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Did evolution autophosphorylate your kinases? (3)

Did evolution autophosphorylate your kinases? (1) Did evolution autophosphorylate your kinases? (2) See also: N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection Reported as: Chemical tags affect ability of RNA viruses to infect cells Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Reported as:  Zika virus infection alters human and viral RNA My comment: Virus-driven hecatombic evolution of all pathology is linked from the failure of energy-dependent phosphorylation to biophysically constrain the RNA-mediated damage to DNA via…

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Ecology replaces the extended evolutionary synthesis

The extended evolutionary synthesis: its structure, assumptions and predictions Excerpt 1) “We label this interpretation the ‘extended evolutionary synthesis’ (EES) but emphasize, contrary to some recent claims (e.g. [10]), that the EES is a developing line of contemporary evolutionary thought that exists within the field, and not a denial of the value of past frameworks or of progress in evolutionary biology. To some readers, the use of the EES label might appear grandiloquent but, as we will show, the significance…

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