Something is antithetical when it is in complete and utter opposition to the character of something. Analysis of protein-coding genetic variation in 60,706 humans reported as: Largest collection of human exome sequence data yields unprecedented tool for diagnosing rare disease …variation that was expected, but not found, in the data offered new insight. Some genes were found to have less than the expected number of missense mutations, which change the protein sequence, or “loss-of-function” mutations, which obliterate protein function. With…