species-specific

De novo gene creation: Ignoring the experimental evidence

Regularly Whiffing Essential Oils Can Retrain Lost Sense of Smell It’s not entirely clear how olfactory training works on a neurological level. Olfactory training links the experience-dependent de novo creation of G protein-coupled receptors to supercoiled DNA. Conserved molecular mechanisms link food odors and pheromones from the innate immune system to the physiology of reproduction. Simply put, autophagy protects all organized genomes from virus-driven entropy and all pathology via the de novo creation of odor receptor genes. See for proof:…

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Controlled amino acid treatment of all pathology

Amino acid studies.com Excerpt: One of the cancer treatments that seems to be proving effective over time is CAAT: Controlled Amino Acid Treatment. CAAT works by restricting certain amino acids from the diet to combat the growth and reproduction of the cancerous cells. Excerpt: doctors can now actively battle cancers, using the best weapons possible, natural amino acids, which are actually designed to make changes in the body. The trick has been to understand which changes are beneficial to cancer…

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The last RNA-mediated theory killer

Search Results for ‘theory killer‘ Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation Excerpt: One limitation of this study (common to most animal studies) is that it was performed on a single mouse strain (C57BL/6J) in one mouse facility. My comment: Differences in the diet of species from microbes to humans have been linked from species-specific amino acid substitutions to all morphological and behavioral phenotypes via transgenerational epigenetic inheritance and the pheromone-controlled physiology of reproduction.…

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Linking RNA structure to function

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

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Controled Stem Cell Expansion

Serine … is one of the proteinogenic amino acids. [It]… is classified as a polar amino acid. My comment: Serine synthesis in the body is linked to glycine, which also may be naturally produced when UV light illuminates simple ices (e.g., combinations of water, methanol, hydrogen cyanide, and ammonia). That suggested to some people that glycine and other amino acids may be easily produced in cold regions of space, and the suggestion, like virtually all suggestions, seems to be believable…

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Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs

Of Cells and Limits Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement. By Anna Azvolinsky | March 1, 2015 Excerpt: The rejection letter came from Francis Peyton Rous who received the Nobel Prize a few years later for his discovery of chicken tumor viruses. My comment: My 2014 invited review of nutritional epigenetics detailed how differences in the microRNA/messenger…

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Dual genomes: exposing the evolution industry

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes Excerpt: “The CDP showed a significant overrepresentation of certain gene ontology (GO) groups (global tests Po0.001–0.009), using the programme FUNC23 (Methods). These groups included GPCRs, in particular olfactory receptors (ORs), and other membrane and cell-surface proteins, as well as proteins related to the immune system, such as the MHC (Class I and II), and drug metabolism…” My comment: Biodiversity “…converges upon a ‘common diplotypic proteome (CDP)’, a distinctive subset…

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Thermodynamic constraints and ecological adaptations sans evolution

Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites Excerpt: “…a two-variable model that combines stability and stress signi ficantly improves predictions. Therefore, both the overall stability [symbol] and the stress [symbol] seem to capture distinct thermodynamic constraints on protein evolution.” My comment: Proteins do not evolve. Nutrients are required. Metabolism of nutrients to species-specific pheromones controls the physiology of reproduction in species from microbes to man. The nutrient-dependent pheromone-controlled physiology of reproduction enables epistasis via nutrient-dependent RNA-directed DNA…

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Physics, Chemistry, and Molecular biology (PCMb)

Physics, Chemistry, and Molecular biology (PCMb) link ecological variation to ecological adaptations via a model of gene-cell-tissue-organ-organ system complexity that I first presented in 1992. After adding gene activation by pheromones, I co-authored a book that linked the pheromone-controlled physiology of reproduction across species from microbes to man: The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002) Since then, others have written books that claimed that pheromones evolved: Pheromones and Animal Behaviour (2003/2014) and one claimed that mammals…

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Behavior (3): All responses are RNA-mediated in bees

See: Honey bees as a model for understanding mechanisms of life history transitions. Excerpt: “In this review we discuss the physiological and genetic mechanisms of this behavioral transition, which include large scale changes in hormonal activity, metabolism, flight ability, circadian rhythms, sensory perception and processing, neural architecture, learning ability, memory and gene expression.” My comment: An earlier review by Eleckonich and Robinson (2000) “Organizational and activational effects of hormones on insect behavior” cited our 1996 review of epigenetically-effected organization and activation…

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