Sperm MicroRNA

The eternal significance of microRNAs and the Vietnam Memorial (1)

Researchers who believe in the mutation-driven evolution of species and mutation-driven differences in human populations have invented another ridiculous hypothesis. Now, they believe in mathematical models that infer: Cultural hitchhiking and competition between patrilineal kin groups explain the post-Neolithic Y-chromosome bottleneck In human populations, changes in genetic variation are driven not only by genetic processes, but can also arise from cultural or social changes. An abrupt population bottleneck specific to human males has been inferred across several Old World (Africa,…

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The tipping point (revisted): 69,000 publications

See first: The tipping point (revisited): 68,000 publications December 21, 2017 On December 24, 2017, I started a “tweet” series on Twitter, which was designed to test the response to accurate information about RNA-mediated energy-dependent biophysically constrained viral latency. Nearly 80,000 impressions have led to few engagements and virtually no discussion during a time when almost 1000 additional published works have been indexed on the PubMed database. In my January 20, 2018 PubMed search for term “microRNA,” among nearly 69,000 results,…

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Energy-dependent RNA methylation (6)

After I published Nutrient-dependent/pheromone-controlled adaptive evolution: a model, Lynnette Ferguson and Justin O’Sullivan invited me to submit this review of nutritional epigenetics for inclusion in a special issue of the journal “Nutrients.” Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (April 10, 2014) Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes…

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Bringing RNA back to epigenetics (20 years later)

Has Contemporary Academia Outgrown the Carl Sagan Effect?  [Subscription required] Excerpt (with my emphasis): [Sean Carroll] offered 13 pieces of advice…: “Do good research; Make an impact in the field; Bring in grant money… Don’t be too well known outside the field; Don’t write a book; Choose your hobbies wisely.” Carroll argued that academics look askance at colleagues that have too high of a public profile. Not out of envy—but because they worry that public scientists care more about their…

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Virus-perturbed alternative splicings

Computing in mammalian cells with nucleic acid strand exchange Abstract excerpt: …we established that functional siRNA could be activated through strand exchange, and used native mRNA as programmable scaffolds for co-localizing gates and visualizing their operation with subcellular resolution. Reported as: Scientists Demonstrate Basics of Nucleic Acid Computing Inside Cells Excerpt: Cells, of course, already know how to sense toxic molecules and the development malignant tendencies, and to then take action. But those safeguards can be turned off by viruses…

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Manufacturing fossil “evidence”

An antagonist suggests that it is appropriate to use math models to fill in the analagous missing dots, which in this case involved manufacturing evidence to be included in the fossil record. ‘Virtual fossil’ reveals last common ancestor of humans and Neanderthals My comment: Serious scientists do not use math models to link atoms to ecosystems. They use what is known about physics, chemistry, and conserved molecular mechanisms. Similarly, they do not introduce analogies or metaphors as substitutes for experimental…

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A two-faced protein enables RNA-mediated DNA repair (5)

The title of the article below about “gut bugs” attests to the fact that the popularity of neo-Darwinism is based on the lack of popularity for any alternative. For example, Schrodinger (1944) claimed: …in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded…

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Epigenetic inheritance of stress-perturbed protein folding

Sperm RNAs Transmit Stress Re: Bale’s group will next try to identify epigenetic changes in embryos that might allow miRNA changes to have an effect in adult animals. Nutrient-dependent microRNAs are the link from viral microRNAs to transgenerational epigenetic inheritance of morphological and behavioral phenotypes. The nutrient-dependent microRNAs typically protect organized genomes from DNA damage linked to the theft of nutrient-energy. The energy theft by viruses links entropic elasticity to genomic entropy, which links viruses to all pathology in the…

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