stem cells

The eternal significance of microRNAs (8)

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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A single base change refutes theistic evolution

Everyone who failed to learn how light-activated endogenous substrates biophysically constrain viral latency is playing “catch up” to serious scientists. The serious scientists know how quantized energy-dependent RNA-mediated cell type differentiation occurs in the context of the physiology of reproduction in all living genera. Rather than accept the fact that the innate immune system of bacteria (CRISPR) linked the pheromone-controlled physiology of reproduction from autophagy to biophysically constrained viral latency, theorists decided to waste money on virus-assisted gene-editing attempts to…

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Autophagy in health and disease (1)

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors Each of these pathways have an intimate relationship with the programmed death pathways of autophagy and apoptosis and share a common link to the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and the mechanistic target of rapamycin (mTOR). Circadian clock genes are necessary to modulate autophagy, limit cognitive loss, and prevent neuronal injury. Non-coding RNAs can control neuronal stem cell…

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A null mutation and healthy longevity?

Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana? Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia Reported as: How to Control…

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Epigenetic facts vs variable recombination theories

6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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Stem cells do not create themselves

Summary: The energy-dependent cellular pathways have been detailed at all levels of examination from atoms to ecosystems in the context of physics, chemistry, and molecular epigenetics. The mere mention of RNA-mediated amino acid substitutions may cause theorists to panic because it eliminates their pseudoscientific nonsense in the context of the claim that proteins do not create themselves. Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis 1) The constant regeneration of stomach epithelium is driven by long-lived stem cells1,…

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Energy-dependent physical and biophysical constraints (7)

See first: Energy-dependent physical and biophysical constraints (6) Stems Cells in the Hypothalamus Slow Aging in Mice My comment to The Scientist Cai says microRNAs could be a potential mechanism by which hypothalamic neural stem cells have such wide-ranging effects on aging, yet he believes that neurogenesis may also be involved. See also: Feedback loops link odor and pheromone signaling with reproduction At least 10,000 neurons in 26 different brain areas appear to transmit signals directly to GnRH neurons.  GnRH…

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Secular humanism and ecoterrorism

Noncoding RNAs Not So Noncoding Excerpt: “Were there going to be dozens of [micropeptides]? Were there going to be hundreds, like there are hundreds of microRNAs?” says Ingolia. “We just didn’t know.” See also: Number of microRNAs in Human Genome Skyrockets Excerpt: “…researchers from Thomas Jefferson University in Philadelphia have released data that adds another 3,707 novel miRNA sequences to the human genome, in addition to the 1,900 sequences previously described. The results from this study were published recently in…

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Ecological speciation. Get it, theorists?

A Prkci gene keeps stem cells in check Excerpt: In the presence of Prkci, the Notch pathway remains silent, and stem cells differentiate into specific cell types. My comment: Several days of attempted discussion led to this question Do you get it now, jvk? My response: Everyone who is not a biologically uninformed science idiot gets it. The Zechiedrich lab‘s focus links energy-dependent base pair changes from atoms to ecosystems. The Rosenberg lab‘s focus on stress shows why others must…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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