stem cells

Orchestrated death: J. Michael Bailey

A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development 10/7/21 Epigenetic manipulation of the human VNTR was sufficient to switch off ZNF558 expression and thereby increase SPATA18 expression. Our data reveal the co-option of a TE-controlling KZFP to regulate a protein-coding gene and how this regulatory network is controlled between species and human individuals by a cis-acting structural variation. Presumably, the molecular mechanisms are the same in people with gender dysphoria. Reported…

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God’s microRNA-mediated Creation of genotypes (7)

Molecular Biology Empowering a community publishing articles in Molecular Biology, including RNA biology, chromatin and epigenetics, gene expression, translation, DNA replication and repair, nuclear organization, gene editing, and much more. Advanced Search 13,006 results for microRNA Most recent: Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis 9/30/21 See also: 43,893 results for viruses and Micrornas 73,770 results for Potential Therapeutic Effect of Micrornas See for comparison: More than 128,300 indexed publications on PubMed…

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God’s microRNA-mediated Creation of genotypes (6)

microRNA 128,290 results. I was too busy to post links to articles when the total number of indexed publications hit 128,000. But see: Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis 9/30/21 These results indicate possible therapeutic use of stable anti-miR-24, albeit administered by other routes, in diseases that are alleviated by STING. miR-24 is known to affect brain development and fetal neuronal differentiation [69]; however these effects should have little bearing on…

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Pheromones protect us from viruses (10)

Twitter Profile: MicroRNA.pro, http://Autophagy.pro & http://RNA-mediated.com link subatomic particles from pH-dependent peptide synthesis to sympatric speciation and healthy ecosystems. Before 4/6/21, I had contributed 40,000 tweets @microRNApro to support claims about how light-activated carbon fixation is linked to healthy longevity in more than 118,400 indexed publications that mention ‘microRNA.’ For a historical perspective on the development of healthy ecosystems, see: Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.) (1994) “The specificity of pheromonal regulation depends…

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The eternal significance of microRNAs (8)

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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A single base change refutes theistic evolution

Everyone who failed to learn how light-activated endogenous substrates biophysically constrain viral latency is playing “catch up” to serious scientists. The serious scientists know how quantized energy-dependent RNA-mediated cell type differentiation occurs in the context of the physiology of reproduction in all living genera. Rather than accept the fact that the innate immune system of bacteria (CRISPR) linked the pheromone-controlled physiology of reproduction from autophagy to biophysically constrained viral latency, theorists decided to waste money on virus-assisted gene-editing attempts to…

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Autophagy in health and disease (1)

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors Each of these pathways have an intimate relationship with the programmed death pathways of autophagy and apoptosis and share a common link to the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and the mechanistic target of rapamycin (mTOR). Circadian clock genes are necessary to modulate autophagy, limit cognitive loss, and prevent neuronal injury. Non-coding RNAs can control neuronal stem cell…

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A null mutation and healthy longevity?

Summary: Food odors and pheromones biophysically constrain all pathology in species from microbes to humans. What kind of biologically uninformed science idiot leaves out everything known to serious scientists about the virus-driven degradation of messenger RNA and tells others they must falsify the neutral null theory that led to claims about a biophysically constrained beneficial “null mutation” in the Amish population of Berne, Indiana? Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia Reported as: How to Control…

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Epigenetic facts vs variable recombination theories

6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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Stem cells do not create themselves

Summary: The energy-dependent cellular pathways have been detailed at all levels of examination from atoms to ecosystems in the context of physics, chemistry, and molecular epigenetics. The mere mention of RNA-mediated amino acid substitutions may cause theorists to panic because it eliminates their pseudoscientific nonsense in the context of the claim that proteins do not create themselves. Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis 1) The constant regeneration of stomach epithelium is driven by long-lived stem cells1,…

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