substitutions

Energy-dependent de novo creation and neurogenesis

See also: Tasting light links energy from creation to adaptation Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning reported as: When neurons are ‘born’ impacts olfactory behavior in mice My summary: The de novo creation of different cell types is placed into the context of their energy-dependent birth and the transgenerational epigenetic inheritance of molecular mechanisms that link virus-driven energy theft to all pathology via olfaction, food odors, and human pheromones. See for comparison: Metabolism and neurogenesis …it…

Read More

Virus-mediated hecatombic evolution

Virus-mediated archaeal hecatomb in the deep seafloor These findings provide new evidence for a possible link between viral infections and chemoautotrophic production in the microbial food web. My comment: I hereby stake my claim to the invention of the term”hecatombic evolution.” At the forthcoming meeting of the Royal Society next month, I expect full consideration to be given to use of “hecatombic evolution” to replace neo-Darwinian evolution and/or the “Modern Synthesis” or mutation-driven evolution until everyone in the world realizes…

Read More

Does metabolism link beneficial mutations to cancer?

Viruses steal nutrients needed by the cell. The theft deregulates protein folding, which is how viruses perturb biophysically constrained nutrient energy-dependent protein folding chemistry. The theft of nutrients by viruses links mutations to all pathology. Nutrients are required for RNA methylation and RNA-directed DNA methylation. Cell types do not hypermethylate unless nutrient-dependent hypermethylation is required to protect organized genomes from virus-driven entropy. Simply put, viruses cause nutrient-dependent hypermethylation when hypermethylation is required to protect organized genomes from virus-driven entropy. Evolutionary…

Read More

A 5-10K comparison of design principles to evolution

Julie Theriot: Discovering Design Principles for Cells and Organisms Excerpt: …there is immense diversity in cellular structures. What are the underlying physical principles that allow these structures to emerge? Julie Theriot argues that protein folding theories fail to explain how cells build large-scale assemblies, and so scientists are working to develop a new theory of cell structure determination. See also: Why are bacteria different from eukaryotes? Excerpt: …there is a bacterium with the wonderful name Gemmata obscuriglobus that is described as…

Read More

The “great filter” is an epigenetic trap

The great filter The silence of universe seems ominous. Was Earth lucky? Thanks to George Ellis​ for alerting others to this. Excerpt: Nick Lane in his magnificent new book The Vital Question thinks that a peculiar feature of all earthly life — that it traps energy in the form of protons pumped across membranes… Excerpt 2) Next, after a couple of billion years, creatures bigger than microbes emerged, once (Nick Lane argues) an energy-per-gene limit was breached by the invention…

Read More

RNA-mediated gene duplication, fixation, and ecological adaptation

Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication Excerpt: The simplicity of this coordination mechanism suggests that it may be widely applicable in a variety of gene regulatory and stress-response settings. Reported as: Bacteria use DNA replication to time key decision Excerpt: “Successful sporulation requires two complete copies of the bacterial chromosome, so coordination between the sporulation decision and the completion of DNA replication is very important,” Narula said. “A good analogy might be a semester-long course in…

Read More

“New” epigenetic mechanism for lifelong learning?

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity Reported as: Lifelong learning is made possible by recycling of histones, study says Also reported as: New epigenetic mechanism revealed in brain cells Excerpt: In humans, researchers used a technique called 14C/12C bomb pulse dating to measure turnover. The technique is based on the fact that high levels of radioactive carbon (14C) were released into the atmosphere during the 1950s and 1960s, when open-air nuclear bomb testing occurred following the…

Read More

Living the life that randomness created? (Sarcasm alert)

The Living Set Mathematical and computational approaches are making strides in understanding how life might have emerged and organized itself from the basic chemistry of early Earth. By Wim Hordijk | June 1, 2015 Excerpt: Put some E. coli in a dish with appropriate nutrients, and after a few days the dish will be teeming with new bacterial offspring. My comment: Put some genetically altered P. fluorescens in a dish and leave them “over-the-weekend” with their missing flagella over-the-weekend. Forget…

Read More

Alternative splicings: epigenetics meets pharmacogenomics

Alternative splicing [is] …a regulated process during gene expression that results in a single gene coding for multiple proteins… [T]he proteins translated from alternatively spliced mRNAs will contain differences in their amino acid sequence and, often, in their biological functions…. See also: Alternative RNA Splicing in Evolution Excerpt: It now appears that alternative splicing is, perhaps, the most critical evolutionary factor determining the differences between human beings and other creatures. See also: From Fertilization to Adult Sexual Behavior Excerpt: Small…

Read More

Epigenetic regulation of aging by glycine and GnRH

Summary:  “…the regulation of two genes involved with the production of glycine, the smallest and simplest amino acid, is partly responsible for some of the characteristics of aging. This indicates that the aging process in the mitochondrion is controlled by epigenetic regulation, not by mutations.” My comment: The broad-based extension of the fact that aging is epigenetically controlled, extends everything known about RNA-mediated cell type differentiation across the life history transitions of all genera. The focus here is on vertebrates,…

Read More
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
error: Content is protected !!