Theory

http://nnjournal.net/article/viewFile/2354/1850/10234

A mental health problem at the highest level (2)

Biologically uninformed theorists and so-called science journalists have ignored their own mental health issues and focussed their attention on the mental health of serious scientists. Some of the serious scientists advise the President of the United States in attempts to help him make America great again by draining the political and academic swamps. It is time to examine the personality disorders of theorists and biologically uninformed journalists for comparison to the mental health of serious scientists and the President of…

Read More

Theorists sell hidden energy (2)

Theorists sell hidden energy (Jan 5, 2017) January 6, 2017 Giant atoms could help unveil ‘dark matter’ and other cosmic secrets The universe is an astonishingly secretive place. Mysterious substances known as dark matter and dark energy account for some 95% of it. Despite huge effort to find out what they are, we simply don’t know. Our model is based on the fact that weakly interacting particles must bounce from the nucleus of the atom it collides with and exchange…

Read More

Evolved patterns of brain stimulation

Evolving deep brain stimulation patterns The method works very similarly to biological evolution, but it occurs inside of a computer,” said Grill. “In our world, instead of a giraffe’s neck getting longer to reach higher leaves, the positions of electric pulses change so that the pattern gets better over time. The pattern that gets better over time is one that theorists claim has evolved. They are wrong. Natural selection for energy-dependent codon optimality in the context of autophagy is linked…

Read More

Modelling life scientifically: RNA-mediated events

Experiment: “An attempt to arrive at an accurate result.” — James V. Kohl (3/27/16) EFBC fellowship class response to Dr. Tom Jordan who asked me to define “experiment” For comparison, see: Experiment: An experiment is a procedure carried out to verify, refute, or validate a hypothesis. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale, but always rely on repeatable procedure and logical analysis of the…

Read More

Becoming biologically informed

RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis Abstract excerpt: In this article, we describe various common RNA toxicity pathways, namely epigenetic gene silencing, nucleolar stress, nucleocytoplasmic transport, bi-directional gene transcription, repeat-associated non-ATG translation, RNA foci formation and cellular protein sequestration. Journal article conclusion: Although protein toxicity was considered to play a major role in the pathogenesis of repeat expansion diseases, we now know that mutant transcripts also induce cell dysfunction and death via multiple mechanisms, such as…

Read More

microRNAs and memory: Why trust a theory?

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems Abstract excerpt: … links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding… manifested in increasing organismal complexity… My comment: The increasing organismal complexity attributed to microRNAs is manifested in the learning abilities and in the memory of…

Read More

Hypotheses and mathematical philosophy

What the Man Described as ‘The Next Darwin’ Has to Say About God Excerpts: …this is a hypothesis, kind of like the multiverse theory. It’s getting a lot of press, but it doesn’t actually have any falsifiable claims yet. There’s absolutely no way to test it. At best, it’s a hypothesis, at worst, it’s really kind of a mathematical philosophy. …life is an inevitable consequence of thermodynamics given the right conditions. My comment: Hypotheses and mathematical philosophy have no explanatory…

Read More

Physicians who practice evolutionary medicine?

Why Do Some Doctors Reject Evolution? Excerpt: After all, evolution is the foundational principle of biology, which, in turn, is the basic science that backs medicine. Ninety-eight percent of scientists, a closely related profession, accept evolution. My comment: I think they probably included too many social scientists who believe that evolutionary theory is something more than pseudoscientific nonsense. Excerpt: Unfortunately, there don’t seem to be great numbers on the percentage of doctors who accept evolution. My comment: Physicians who accept…

Read More

From deep time into real time: What evolutionary processes?

Rapid evolution of a native species following invasion by a congener Abstract excerpt: “…the lizard Anolis carolinensis moved to higher perches following invasion by Anolis sagrei and, in response, adaptively evolved larger toepads after only 20 generations.” My comment: This indicates that the behavior evolved before the species, in response, evolved larger toepads. Reported as: Florida lizards evolve rapidly, within 15 years and 20 generations Karl Grammer’s comment: “Proofs for evolutionary processes…” What evolutionary processes? RNA-directed DNA methylation links the…

Read More

ALPHA GENOMIX

ALPHA GENOMIX LABORATORIES INC Alpha genomics (for those unfamiliar with their spelling) Re: On this team, Dr. Hani El Shawa, is also first author of Prenatal Ethanol Exposure Disrupts Intraneocortical Circuitry, Cortical Gene Expression, and Behavior in a Mouse Model of FASD. The Journal of Neuroscience, 27 November 2013, 33(48): 18893-18905. Excerpt: “Changes in gene expression reported in this study may be caused by altered DNA methylation, an epigenetic modification that cells use to mediate gene expression (Moore et al.,…

Read More