Top-down causation

Natural models inspire future therapeutics (2)

June 24, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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The concept of a species (2)

June 12, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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The science of peaceful coexistence among members of the same species and human populations that are vilified starts with an understanding of the birds and the bees, which seems to be beyond the ability of neo-Darwinian theorists and Big Bang cosmologists to grasp. See for comparison: Birds from different species recognize each other and cooperate Article excerpt 1): Australian fairy-wrens not only recognize individual birds from other species, but also form long-term partnerships that help them forage and defend their…

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Laws of biology vs no laws of physics

June 9, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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There Are No Laws of Physics. There’s Only the Landscape In Einstein’s view, if we probed the essence of physics deeply enough, there would be one and only one way in which all the components — matter, radiation, forces, space and time — would fit together to make reality work, just as the gears, springs, dials and wheels of a mechanical clock uniquely combine to keep time. Reported as:  Physicist concludes there are no laws of physics It was June…

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Biologically uninformed science idiot: Self-defense (2)

June 2, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA–Mediated Epigenetic Heredity, Subatomic
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Summary: “Construction of automata” is the operative phrase. But you must be willing to believe that the automata create themselves outside the context of the creation of sunlight and light-activated endogenous substrates in all cell types of all living genera. Causation, constructors and codes A formal definition of codes in general, and organic codes in particular, allows the relational diagram to be extended so as to capture this translation of formal cause into process. The extended relational diagram is used…

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The tipping point (revisited): 73,000 publications

May 16, 2018
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology
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Summary: The Bill and Melinda Gates Foundation appears to be funding misrepresentations of what serious scientists know about biophysically constrained viral latency, as if no one knew that the effect of virus-driven energy theft in a computer processing unit (CPU) is the same as the effect of bacteriophages on the human brain. The countdown that led scientific creationists in South Korea to force the denuclearization of North Korea started 2 years ago (today). 5, 4, 3, 2, 1 Predicting microRNA-disease…

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An evolutionary theory killer

MicroRNA-mediated denuclearization (6)

April 25, 2018
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology
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Summary: The EDAR V370A isoform links one quantized energy-dependent base pair change from changes in ultraviolet light (UV) exposure to fixation of one amino acid substitution. The substitution differentiates the cell types of mice and humans in the context of a mouse-to-human model of nutritional epigenetics and microRNA-mediated denuclearization in North Korea. Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk …a genetically isolated population living in this environment…

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Sympatric Speciation vs pseudosceintific nonsense (4)

April 10, 2018
James Kohl
RNA Directed
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The energy-dependent creation of ATP synthase and the energy-dependent creation of the microRNA repertoire have now been linked to biophysically constrained RNA-mediated sympatric speciation via the innate immune system in species from Axolotyls to A. davidianus infected with ranavirus. MicroRNA repertoire and comparative analysis of Andrias davidianus infected with ranavirus using deep sequencing MicroRNA mediated host-pathogen interactions are important in antiviral defense. See: Meet the creature that can regenerate its brain and resist cancer. (video) Identification and characterization of the…

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Ecological adaptation: a new definition of heredity (4)

March 9, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Experimentally Induced Metamorphosis in Axolotl (Ambystoma mexicanum) Under Constant Diet Restructures Microbiota Accompanied by Reduced Limb Regenerative Capacity (2018) Our results show that distinct bacterial communities inhabit individual organs of Axolotl and undergo substantial restructuring through metamorphosis. The restructuring during metamorphosis is biophysically constrained by feedback loops that link olfaction from food odors and pheromones to the creation of enzymes in bacteria and the secretion of the vertebrate decapeptide hormone GnRH (gonadotropin releasing hormone). See: Gonadotropin-releasing hormone agonist binding in…

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Creating biophysically constrained viral latency (2)

February 28, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation
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Creating biophysically constrained viral latency (2) Serious scientists have reached the point where they are finally ready to expose the pseudoscientific nonsense during Evolution – Genetic Novelty/Genomic Variations by RNA Networks and Viruses and also during Schrödinger at 75 – The Future of Biology – September 2018. Until then, pseudoscientists may want to see these examples of accurate information about top-down causation. MicroRNA Processing Gene Methylation and Cancer Risk Methylation of three CpGs (DROSHA: cg23230564, TNRC6B: cg06751583, and TNRC6B: cg21034183) was prospectively…

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Creating biophysically constrained viral latency (1)

February 28, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed
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When a theorist or so-called science journalist claims that not enough is known about how quantum physics must be linked from energy-dependent top-down causation to quantum chemistry or how energy-dependent bottom-up quantum chemistry is linked to biophysically constrained viral latency, ask if they have seen this. Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism Caption: Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of…

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