Top-down causation

An evolutionary theory killer

A reversible TCA cycle in a thermophile (2)

Summary: The energy-dependent creation of ATP has been linked from the energy-dependent creation of RNA to feedback loops that link the pheromone-controlled physiology of reproduction to biodiversity in species from microbes to humans via olfaction and pheromones. Anyone who continues to try to place the facts into the context of brain stimulation by visual input and ignore the facts about how the creation of microRNAs must be linked from creation of the sense of smell to all biophysically constrained viral…

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The MicroRNAome Strikes Back: A Sokalian hoax (10)

Linda Buck, Ben Feringa, Michael Gazzaniga, Christof Koch, Nick Lane and Svante Paabo are among the presenters who will almost undoubtedly discuss some or all of my claims. Prepare to ask questions or intelligently discuss accurate representations of top-down causation by watching this: The energy-dependent creation of the microRNAome protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all pathology. See: The Bull Sperm MicroRNAome and the Effect of Fescue…

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A Mathematical Model Links Quantum Physics to Quantum Souls (1)

Historical facts: All energy-dependent cell type differentiation is biophysically constrained by the de novo creation of microRNAs and enzymes that metabolize food and drugs. All food energy-dependent metabolism occurs in the context of microRNA-mediated cause and effect and the physiology of pheromone-controlled reproduction. The food energy-dependent pheromone controlled physiology of reproduction in bacteria links what organisms eat to the transgenerational epigenetic inheritance of their morphological and behavioral phenotypes. The virus-driven degradation of messenger RNA has been linked to all pathology…

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Thanks again for asking about DNA methylation

Re: RNA-directed DNA methylation (1996) See: From Fertilization to Adult Sexual Behavior Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. See also: RNA-directed DNA methylation: an epigenetic…

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Your indifference is killing you and others

Summary: Coherence-inducing mechanisms is double-speak for mechanisms that are nutrient-dependent and pheromone-controlled. Feedback loops link odor and pheromone signaling with reproduction has been presented in double-speak as Looplessness in networks is linked to trophic coherence We are currently studying the entropy of the coherence ensemble we defined for this work. “In general, higher trophic coherence would be associated with lower entropy states, which means that if networks are more coherent than the random expectation there must indeed be some kind…

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Energy-dependent physical and biophysical constraints (6)

Conclusion: Like Richard Dawkins, Magnus S. Magnusson is a pseudoscientist. A light-induced change in an endogenous substrate found in all cell types of all living genera links femtosecond blasts of UV light from the de novo creation of the innate immune system to RNA-mediated DNA repair in species from microbes to humans. The theft of quantized energy by viruses has been linked to all pathology. The speed at which quantum decoherence occurs makes it difficult for virus-driven energy theft to…

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Energy-dependent physical and biophysical constraints (2)

Summary: The mind does not exist in nature. It is a manifestation of how ecological variation must be linked to the creation of food energy-dependent pheromone-controlled ecological adaptations. Energy-dependent physical and biophysical constraints (1) The energy-dependent de novo creation of all receptors is biophysically constrained. See: Channel opening and gating mechanism in AMPA-subtype glutamate receptors This was reported as: Scientists capture first image of major brain receptor in action Defects in glutamate receptors, or the processes they mediate, are implicated…

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Energy-dependent epigenetic translation to mRNA stability (3)

Energy-dependent epigenetic translation to mRNA stability (2) Energy-dependent epigenetic translation to mRNA stability (2) See for comparison this treatise on climate change packaged as information on the evolution of a flying snake. Fossil ‘winged serpent’ is a new species of ancient snake At the time that Zilantophis dwelled there, the site was a sinkhole surrounded by forest, attracting a variety of animals. The local fauna included ancient representatives of familiar North American creatures such as bears, beavers and salamanders. Others…

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Energy-dependent epigenetic translation to mRNA stability (2)

See first: Energy-dependent epigenetic translation to mRNA stability Universe’s ultraviolet background could provide clues about missing galaxies Simulations show that there should be more small galaxies in the Universe, but UV radiation essentially stopped them from developing by depriving them of the gas they need to form stars. UV light constrains the creation of galaxies and also biophysically constrains the creation of the mutations in cancer cells. When will Stephen Hawking and other biologically uninformed theorists admit that their ridiculous…

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Energy-dependent microRNA biogenesis

Published May 3, 2017 Genetic variation and RNA structure regulate microRNA biogenesis …primary sequence determinants and RNA structure are key regulators of miRNA biogenesis. Genetic variation aka primary sequence determinants are energy-dependent and RNA-mediated. Energy-dependent RNA methylation is an experience-dependent link from natural selection for energy-dependent codon optimality. Natural selection for energy-dependent codon optimality links ATP-dependent microRNA biogenesis to RNA biosynthesis. Ridiculous attempts to portray energy-dependent top-down causation as if genetic variation came first may continue for another 52 years.…

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