Top-down causation

Metabolic Phenotyping Research

Global Consortium to Conduct Metabolic Phenotyping Research Consortium members in six countries will use chromatography, mass spectrometry, and other technologies to conduct metabolic phenotyping research that examines the dynamic interactions between genes, environments, microbiomes, diets, and lifestyles, and their collective impact on disease. My Predictions. 1. They will link energy as information to healthy longevity. 2. They will report their findings as if they discovered new molecular mechanisms. 3. The mechanisms will link the anti-entropic virucidal energy of ultraviolet light…

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Energy-dependent purifying selection / autophagy (3)

See also: Energy-dependent purifying selection / autophagy (2) But see: Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters Re: “…the interactomes of 31,253 annotated promoters in 17 human primary blood cell types.” Excerpt: Here, we link thousands of GWAS SNPs to their putative target genes and prioritize more than 2,500 potential disease-associated genes, three-quarters of which were not previously implicated. Reported as: Researchers identify missing links that connect human DNA variation with disease My comment:…

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From Precis to Proof in 6000 years

Religious texts, such as The Holy Bible appear to be like a Precis of works from God. He seems to be explaining energy-dependent creation in the context of what is currently known to serious scientists about biophysically constrained RNA-mediated protein folding chemistry, healthy longevity and RNA-mediated biodiversity. God made it perfectly clear, in advance, that all miraculous biodiversity is energy-dependent. Energy as information is the theme that extends to the weekend resurrection of the bacterial flagellum in P. fluorscens. Biologically…

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Attacking Young Earth Creationists

‘Residual diversity estimates’ do not correct for sampling bias in palaeodiversity data Abstract excerpt: Evolutionary dynamics such as speciation are inherently a phylogenetic process, and only an explicitly phylogenetic approach will correctly model this process. Reported as: Flawed analysis casts doubt on years of evolutionary research The method assumes that variations in the number of different fossils at any given time are a reflection of how much rock was available. It has been used in more than 150 published research…

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Consciousness is simply food rearranged

The claim that consciousness is simply food rearranged can be placed into a historical perspective that crosses more than 70 years. Historical perspective: (1944) What Is Life? Excerpt: Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded,…

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Innate immunity and multiplexing

Scientists Hope to Cultivate an Immune System for Crops by Carl Zimmer Excerpt: The complex microbial world in the soil may protect plants much like our immune system protects our bodies. My comment: The speed of light on contact with water links the sun’s quantized anti-antropic virucidal energy from the de novo creation of nucleic acid precursors to biophysically constrained RNA-mediated protein folding chemistry and supercoiled DNA, which protects all living genera from virus-driven energy theft and genomic entropy. See…

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Major transition ends use of silly theories

Major transitions in human evolution This theme issue focuses on key evolutionary transitions to understand the interaction of biology, behaviour, culture and environment. This issue is dedicated to Richard Leakey, whose critical discoveries have provided evidence for many of the key phases, and who has inspired much of the work discussed here. This issue is based on a joint Royal Society and British Academy discussion meeting held in October 2015. This issue is now available to read online. Reported as:…

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Masters of deception about nature (2)

See my other blog posts on RNA methylation Thanks for your review of How Can Physics Underlie the Mind?: Top-Down Causation in the Human Context (The Frontiers Collection) Others linked the sun’s anti-entropic virucidal energy from energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects all organized genomes from virus-driven energy theft and genomic entropy. Ellis comments on at least one of Schrodinger’s claims from “What is Life?” but he largely ignores the…

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RNA methylation, behavior, and disease

Epigenetics and Genetics of Viral Latency by Paul M. Lieberman (May 11, 2016)   My comment: Lieberman succinctly confirmed the fact that …viral latency is responsible for life-long pathogenesis and mortality risk… His simplistic conclusion also attests to the fact that there is no defined boundary between epigenetics and genetics. Epigenetic effects on metabolic networks must be linked to genetic networks via the energy-dependent innate immune system. That’s how all serious scientists knew they would need to link angstroms to ecosystems…

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Energy-dependent RNA methylation (9)

Epigenetics and How Our Decisions Affect Our DNA Excerpt (with my emphasis): With the Genetics and Genomics 2016 virtual conference now on demand, we are extending the genetics conversation into this month with a new infographic. Epigenetics has been in the news quite a bit lately as researchers have been able to learn more about its process and influences. It turns out that epigenetics is an ever-changing process within our cells, causing more rapid modification within a generation. Unlike standard…

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