Top-down causation

Neo-Darwinism failed in 1995

We replaced neo-Darwinian theory with what was known about the nutrient-dependent pheromone-controlled physiology of reproduction in The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002) See also: The Darwin Code by Greg Bear Evolution rising from the grave The pioneering thinkers of yesterday are the devoted traditionalists of today. New ideas enter science grudgingly. New paradigms are resisted with a vengeance. Living with the Neanderthals …the preposterous ideas of yesterday are the unshakeable dogmas of today, and the…

Read More

Wasted Templeton Funding (3)

See also: Wasted Templeton Funding (2) Templeton grant funds evolution rethink Excerpt: …parents can influence offspring not just through their DNA but by passing on the microorganisms they host or by transmitting epigenetic marks to subsequent generations. “Innovation may be a developmental response that becomes stabilized through genetic changes,” explains Armin Moczek, an evolutionary developmental biologist at Indiana University, Bloomington. My comment: He has not explained how nutrient energy-dependent changes in base pairs link hydrogen-atom transfer in solutions from microRNA…

Read More

Molecular Diagnostics: What is unprotected life (4)

Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions Excerpt: Nature has developed a vast array of voltage-responsive proteins. To improve our ability to optimize the voltage sensitivity, kinetics, and signal size of GEVIs, an in silico search strategy was developed to identify potential voltage-sensing proteins since new genomes are routinely being sequenced. The use of a conserved amino acid motif in the second transmembrane segment of the voltage-sensing phosphatase…

Read More
RNA Mediated

Metaphysical science vs theory

I’ve wasted too much time attempting to explain biologically-based facts to the biologically uninformed discussants on Science X network. This is an attempt to salvage some of the time and to move forward.  See: New comments posted on Science X network: – A natural history of neurons: Diverse mutations reveal lineage of brain cells : 1 new comment – Study sheds light on powerful process that turns food into energy : 1 new comment – Study adds to evidence that…

Read More

Viruses come alive: Tree of life pseudoscience

See also: The creation and activation of GPCRs ‘Tree of life’ for 2.3 million species released This comment was removed from a “tree of life” discussion site by the “site staff.” In the context of anonymous “peer” review, the comment was removed for the following reason: PSEUDOSCIENCE, with an added threat that my account might be suspended in case of regular violations of the guidelines that led the “site staff” to remove this comment. Young earth creationists addressed the “Tree…

Read More

Hijacked light energy and vertebrate pathology

The spectrum of the sun Excerpt: Here are all the visible colors of the Sun, produced by passing the Sun’s light through a prism-like device. … Since different types of gas absorb different colors of light, it is possible to determine what gasses compose the Sun. Helium, for example, was first discovered in 1870 on a solar spectrum and only later found here on Earth. Today, the majority of spectral absorption lines have been identified — but not all. Most…

Read More

Appetite for ingesting theories (raw)

On The Edge of Neuroscience and Psychology Facebook Group, no one seems interested enough to discuss the difference between an epigenetic effect on hormones and an affect of hormones on behavior. Without a starting point for discussion, there may be no further comments on Goy, R. W., and McEwen, B. S. (1980). Sexual Differentiation of the Brain. MIT Press, Cambridge, MA. Without discussion of nutrient-dependent RNA-mediated sexual differentiation of cell types in the brain, there is no way to link…

Read More

DNA Methylation and organized genomes

This open access review that is linked from the title (below) will appear in the next issue of Int J Biol Sci 2015; 11(5):604-617. doi:10.7150/ijbs.11218 It is a excellent, albeit incomplete, review of how nutrient-dependent RNA-directed DNA methylation and RNA-mediated amino acid substitutions link the epigenetic landscape to the physical landscape of DNA via the biophysically constrained chemistry of cell type differentiation and the physiology of reproduction in all genera. The review is incomplete because they do not start with…

Read More

Biology by itself

Astrobiology or Earth’s Biology – which ? Excerpt: “…isn’t biology by itself supposed to tell everyone the just what “does” happen or what “did” happen in the past?” Top-down causation: an integrating theme within and across the sciences? The first author is George FR Ellis. “He co-authored The Large Scale Structure of Space-Time with University of Cambridge physicist Stephen Hawking, published in 1973, and is considered one of the world’s leading theorists in cosmology.[1] He is an active Quaker and in 2004 he won…

Read More

Origin of life and cancer (1,2,3)

1) On the Origins of Life The physics of the light-induced de novo creation of the amino acids was placed into the context of  ‘cyanosulfidic’ protometabolic systems chemistry. The systems chemistry links substitution of achiral glycine in the gonadotropin releasing hormone (GnRH) decapeptide to the biophysically constrained nutrient dependent RNA-mediated chemistry of protein folding in all vertebrates. The role of food odors and hormone-controlled cell type differentiation in all vertebrates also links changes in the balance of viral microRNAs and…

Read More