transcription factor

Positive feedback loops and epigenetic traps

Transcription factor trapping by RNA in gene regulatory elements Conclusion: …bidirectional transcription of active enhancers and promoters evolved, in part, to facilitate trapping of TFs at specific regulatory elements. The model also suggests that transcription of regulatory elements produces a positive-feedback loop that may contribute to the stability of gene expression programs in cells. The Positive feedback loops and epigenetic traps

Let there be anti-entropic light (3)

See also: Let there be anti-entropic light (1) and Let there be anti-entropic light (2) NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program and Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions were reported as: Master switch for brain development found Excerpts: Let there be anti-entropic light (3)

Exosomes and the RNA-mediated future of medicine (2)

GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson’s Disease Mouse Model Excerpt: …genetically-modified macrophages released exosomes with incorporated GDNF that may facilitate GDNF transport into the target cells and preserve it against degradation. published 9/17/14 and reported on 9/11/15 as: Smart cells teach neurons damaged by Parkinson’s to heal themselves Excerpt: In addition to delivering Exosomes and the RNA-mediated future of medicine (2)