transcription factors

Autophagy in health and disease (1)

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors Each of these pathways have an intimate relationship with the programmed death pathways of autophagy and apoptosis and share a common link to the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and the mechanistic target of rapamycin (mTOR). Circadian clock genes are necessary to modulate autophagy, limit cognitive loss, and prevent neuronal injury. Non-coding RNAs can control neuronal stem cell…

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RNA-mediated adult learning, memory, and neurogenesis

Here is a way to assess the power of the media-industrial complex to suppress accurate representations of biophysically constrained biologically-based cause and effect. Wait to see whether this experimental evidence is reported in the science news, or how it is reported. Enriched Environment Increases PCNA and PARP1 Levels in Octopus vulgaris Central Nervous System: First Evidence of Adult Neurogenesis in Lophotrochozoa The experimental data obtained by immunohistochemistry and western blot assay using proliferating cell nuclear antigen and poli (ADP-ribose) polymerase…

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Dobzhansky 1973 and precision medicine (4)

See: Dobzhansky 1973 and precision medicine (3) Evidence-based medicine has been hijacked: a report to David Sackett Fake news See for comparison: Sugar Gliders, Flying Squirrels, and How Evolutionists Explain Away Uncooperative Data …contradictory evidence drives evolutionists to embrace irrational just-so stories. Natural selection cannot “adapt” anything. Natural selection kills off the bad designs. It cannot influence the random mutations that must, somehow, come up with such amazing designs. This is the hard reality, but in order to rationalize the…

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Energy-dependent chirality (2)

See Energy-dependent chirality 2013 MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination See also E. Ben-Jacob Ben-Jacob et al., have linked everything currently known about natural information processing from natural selection for energy-dependent codon optimality to healthy longevity and from virus-driven energy theft to mutations that cause cancer. See for comparison: LH Tsai Tsai laboratory Our primary goal is to elucidate the mechanisms underlying neurological disorders affecting learning & memory. The major research areas include age disorders, autism, and Alzheimer’s disease. 2012…

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Did evolution autophosphorylate your kinases? (3)

Did evolution autophosphorylate your kinases? (1) Did evolution autophosphorylate your kinases? (2) See also: N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection Reported as: Chemical tags affect ability of RNA viruses to infect cells Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Reported as:  Zika virus infection alters human and viral RNA My comment: Virus-driven hecatombic evolution of all pathology is linked from the failure of energy-dependent phosphorylation to biophysically constrain the RNA-mediated damage to DNA via…

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A working model of “captured” genes

Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice Conclusion: … we propose as a working model that syncytins have been captured primarily as a placental gene, but that some expression in the muscle is taking place (possibly as a consequence of regulatory processes and transcription factors shared by placenta and muscle), and that a “collateral” effect of the capture of such genes -with a clear-cut fusogenic activity- is an add-on contribution…

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RNA methylation (2)

Conditioning as an adjunct in the pharmacotherapy of lupus erythematosus Several studies have provided evidence suggesting that “placebo effects” represent conditioning phenomena and that learning processes influence the response to placebo medication. This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli. The regimen was based on conditioning experiments with animals who had lupuslike autoimmune disease. After the initial pairings, the taste alone…

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RNA-mediated DNA modifications

A new way to discover DNA modifications Excerpt: Using their approach, which combines bioanalytical chemistry, comparative genomics, and a special type of DNA sequencing, the team has discovered a DNA modification that helps bacteria to protect their genomes from viral infection. My comment: There is one way to link nutrient-dependent microRNA flanking sequences from adhesion proteins to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. It starts with energy-dependent changes in hydrogen-atom transfer in…

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