Transcription

microRNA-mediated replication timing (5)

July 2, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in: pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21 Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of…

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microRNA-mediated replication timing (2)

June 27, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Transcription typically requires the energy-dependent Creation of the enzyme RNA polymerase. Intelligent serious scientists know that enzymes do not automagically create themselves, and most of them realize that transcription began when God Created the anti-entropic virucidal energy of sunlight. The 6/4/21 cover of Science Magazine, places that fact about biophysically constrained transcription into the context of pH-dependent oxidative phosphorylation. However, McEwen et al’s claims from 1964 are not included in the content from “Structures of the human Mediator and Mediator-bound…

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An evolutionary theory killer

The eternal significance of microRNAs (3)

April 13, 2018
James Kohl
Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary:  RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment was not linked to sympatric speciation via The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression Something has gone horribly wrong.   I suspect the overwhelming ignorance of biologically uninformed theorists is the problem because their silence is deafening. When trapped by their ridiculous theories, they no longer kick, scream, or bite (like weasels). They participate in so-called marches like the 2018 March for…

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The eternal significance of microRNAs (2)

April 12, 2018
James Kohl
Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril. The Immune Landscape of Cancer (2018) Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune…

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Is meat protein unhealthy? (2)

April 5, 2018
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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See also: Microbiome-Grade DNA Extraction Kits …the thermal and chemical methods effectively lyse the gram-negative organisms and boost their population in the final profile, amplifying the bias. This suggests that all links from food energy-dependent de novo creation of the pheromone-controlled biophysically constrained bull sperm microRNAome have been misinterpreted in the context of virus-driven fescue toxicosis. The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression …the miRNA profile of mature ejaculated sperm may in fact…

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Is meat protein unhealthy? (1)

April 5, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality Reported as: Meat protein is unhealthy, but protein from nuts and seeds is heart smart In the context of everything known about how the creation of anti-entropic virucidal light must be linked to all biodiversity on Earth, watch this ridiculous misrepresentation of the honeybee model organism. Food energy-dependent microRNA-mediated pheromone-controlled biophysically constrained viral latency is portrayed as if visual input was most important. Bee swarms work like…

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Autophagy is the antiphage defense strategy (2)

January 17, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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2/15/17 Energy as information and constrained endogenous RNA interference (video) The 6.46 minute-long technical presentation (above) from the Precision Medicine Virtual Conference is difficult to understand.Thus, 10 months later, Nik Willmore asked: 12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore @nikwillmore 12/25/17 Replying to @nikwillmore @jhewitt123 God created the anti-entropic virucidal energy of sunlight and…

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Enzyme-constrained interethnic biodiversity (4)

January 10, 2018
James Kohl
Diseases & Disorders, microRNA editing, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression
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No, they don’t. See: Why Is This Bacterium Hiding in Human Tumors? Whether Fusobacterium nucleatum causes colon tumors is unknown. But a new study hints that it may be “an integral part of the cancer.” Serious scientists have linked bacteriophages to all virus-driven pathology. Cancer is a virus-driven pathology. That’s the truth! In  the New York Times article by Gina Kolata she wrote: “The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon…

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Pseudoscientists hate what science explains! (3)

August 17, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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See also: Pseudoscientists hate what science explains (2) Summary: In addition to germline silencing via information transfer to the physical landscape of supercoiled DNA, multicopy transgene arrays are linked from changes in the microRNA/messenger RNA balance to variation in their somatic expression level. That fact helps to establish the difference between healthy longevity and pathology across generations. Problems with DNA replication can cause epigenetic changes that may be inherited for several generations My summary: The polycomb repressive complex 2, additional…

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UV light and non-coding RNA

May 9, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Ecology, Model Organisms, RNA methylation, RNA-directed DNA methylation, Variations
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UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene …these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. Intriguingly, the switch between ASCC3 isoforms occurs on more than one level, in that the long mRNA isoform encodes a protein, functioning in the context of the ASCC complex and required for maintaining transcriptional suppression in the late stages of…

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