Transposons

Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Consciousness is simply food rearranged

The claim that consciousness is simply food rearranged can be placed into a historical perspective that crosses more than 70 years. Historical perspective: (1944) What Is Life? Excerpt: Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded,…

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RNA-mediated theory killers (4)

DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer Excerpt: At this moment, DNA methylation and non-coding RNA including with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) represent the largest body of available literature on epigenetic biomarkers with the highest potential for cancer diagnosis. My comment: The SLC19A3 microRNA was mentioned in the context of cancer and brain development in The impact of new technologies on clinical decision-making in health care. The location of the base…

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Preventing genomic entropy

Tethering Transposons Excerpt: Transposons—thought to be related to viruses—can copy themselves and insert randomly around the genome. A paper published today (October 15) in Science provides a greater understanding of how cells shut down these rogue jumping genes. My comment: Shouldn’t someone else be claiming that nutrient-dependent microRNAs prevent the accumulation of viral microRNAs that leads to perturbed protein folding, which links mutations to all pathology in the context of an atoms to ecosystems model? Nutrient-dependent pheromone-controlled ecological adaptations: from atoms…

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“First” evidence

First evidence of how parents’ lives could change children’s DNA 17:00 04 June 2015 by Helen Thomson Excerpts: Surani’s team analysed methylation patterns in a type of fetal cell that later forms a fetus’s own sperm or eggs. We would expect these cells to have been wiped clean when the fetus’s epigenome was reset at the early embryo stage. “However, about 2 to 5 per cent of methylation across the genome escaped this reprogramming,” says Surani. Marcus Pembrey, emeritus professor…

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MicroRNAs and invasive phenotypes

Variability helps mammals to become invasive Excerpt: The authors argue that species exposed to a novel environment will have higher chances of surviving if they are variable and can therefore adapt to many different environmental conditions. My comment: Nutrient-dependent pheromone-controlled morphological and behavioral phenotypes are linked by microRNAs to adaptive radiation and to all of extant biodiversity. For an example of the role of RNA-mediated events that link metabolic networks to genetic networks, see: “Large Numbers of Novel miRNAs Originate…

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MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations  “Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009) Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with evidence that attested to the involvement of epigenetics in the context of olfactory/pheromonal input and the developmental origins of hormone-organized and hormone-activated adult sexual behavior.…

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