Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how Chromatin: The structure of DNA

RNA-mediated theory killers (4)

DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer Excerpt: At this moment, DNA methylation and non-coding RNA including with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) represent the largest body of available literature on epigenetic biomarkers with the highest potential for cancer diagnosis. My comment: The SLC19A3 microRNA was mentioned RNA-mediated theory killers (4)

Preventing genomic entropy

Tethering Transposons Excerpt: Transposons—thought to be related to viruses—can copy themselves and insert randomly around the genome. A paper published today (October 15) in Science provides a greater understanding of how cells shut down these rogue jumping genes. My comment: Shouldn’t someone else be claiming that nutrient-dependent microRNAs prevent the accumulation of viral microRNAs that leads Preventing genomic entropy

“First” evidence

First evidence of how parents’ lives could change children’s DNA 17:00 04 June 2015 by Helen Thomson Excerpts: Surani’s team analysed methylation patterns in a type of fetal cell that later forms a fetus’s own sperm or eggs. We would expect these cells to have been wiped clean when the fetus’s epigenome was reset at “First” evidence

MicroRNAs and invasive phenotypes

Variability helps mammals to become invasive Excerpt: The authors argue that species exposed to a novel environment will have higher chances of surviving if they are variable and can therefore adapt to many different environmental conditions. My comment: Nutrient-dependent pheromone-controlled morphological and behavioral phenotypes are linked by microRNAs to adaptive radiation and to all of MicroRNAs and invasive phenotypes

MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations  “Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009) Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with MiRNAs methylation and ecological adaptation sans mutations