turnover

Light, behavior and autophagy, a gender-specific risk factor

Structure of photosystem II and substrate binding at room temperature Excerpt: PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). New, detailed snapshots capture photosynthesis at room temperature The living machinery responsible for photosynthesis – while commonplace and essential to life on Earth – is still not fully understood. It is understood at every level of…

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Light ‘drives’ adaptation; nothing ‘drives’ evolution (3)

See also Light ‘drives’ adaptation; nothing ‘drives’ evolution (2) 100 feet below the surface bioluminescent organisms are the dominant light source, study shows Excerpt: “Luminescent marine organisms each have a unique light signature. By looking at the time series light generated by a flash within the instrument, we were able to determine who was there making the flash,” Cohen explained. “It’s a useful tool, particularly at this time of year when relatively few species are present.” Bioluminescence is known to…

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The last RNA-mediated theory killer (2)

Autophagy (epigenetically effected by nutrient-energy and controlled by the physiology of reproduction) See for comparison: Virus-driven energy theft and epigenetically-effected autophagy Selleck Chem product use citations Excerpts: Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses. A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer. The number of citations to published works that link the use of…

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Base pairs, olfaction and RNA thermometers

RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Antithetical conclusions (4)

Evidence for sex-specific genetic architectures across a spectrum of human complex traits …will need to disentangle whether sex genetic heterogeneity may arise as a consequence of interactions with genetic loci located on the sex chromosomes, differences in gene control due to differences in the sex-specific cellular environment, or more general differences in environmental exposures between the sexes. Nutrient energy-dependent pheromone-controlled sex differences in the cell types of species from yeasts to humans link changes in the microRNA/messenger RNA balance and…

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Antithetical conclusions (3)

Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model This is part of the Theme issue ‘Coupling geometric partial differential equations with physics for cell morphology, motility and pattern formation’ Excerpt: “The computed ligand concentration and receptor occupancy on the evolving cell membrane are shown in figure 5.” Conclusion: “…the detailed information gained through simulations of single cells or the interaction of a few cells could be used to better inform agent-based approaches and the…

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Non-random pheromone-controlled cell type differentiation

Experience-Dependent Plasticity Drives Individual Differences in Pheromone-Sensing Neurons Aug 17, 2016   •Individual differences in cell types are not random •Sex differences in pheromone-sensing neurons are controlled by experience •Changes in specific cell types are governed via “use it and lose it” plasticity •Targeting plasticity to specific cell types changes animal behavior This was reported as: Long-term exposure to female scents changes courtship behavior in male mice The senior author co-authored Chromatin remodeling inactivates activity genes and regulates neural coding…

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Did “Nature” kill Steve Jobs? (2)

See also: Did “Nature” kill Steve Jobs? In my model of biophysically constrained energy-dependent protein folding chemistry and RNA-mediated cell type differentiation, the nutrient-dependent pheromone-controlled physiology of reproduction links the innate immune system to supercoiled DNA, which protects all organized genomes from virus-driven entropy. For comparison to my model, see: Evolution 2016 Videos (Indexed) Youtube videos Posters See also for comparison: Viruses Have Guided the Path of Human Evolution Excerpt: Whenever a viral epidemic tears through a community, there are…

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Energy-dependent biodiversity (2)

This will be my next post to the “Creationism” FB group, where biologically uninformed antagonists have been attacking me on all my other posts or my comments on the posts of others. See, for example: In a series of four presentations during three online conferences: “Neuroscience” “Molecular Diagnostics” “Genetics and Genomics,” I linked Einstein’s math and physics, from Schrodinger’s claims about anti-entropic energy to Dobzhansky’s claims about amino acid substitutions and cell type differentiation in many different species… Currently, more…

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