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Dobzhansky 1973 and Precision Medicine (2)

January 22, 2017
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See also: Dobzhansky 1973 and precision medicine What Did Neanderthals Leave to Modern Humans? Some Surprises A few years ago, the Swedish geneticist Svante Paabo received an unusual fossilized bone fragment from Siberia. He extracted the DNA, sequenced it and realized it was neither human nor Neanderthal. Savante Paabo co-authored this refutation of neo-Darwinian nonsense in 2003.Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees It links natural selection for energy-dependent codon optimality from the pheromone-controlled physiology…

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Light, behavior and autophagy, a gender-specific risk factor

November 22, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation
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Structure of photosystem II and substrate binding at room temperature Excerpt: PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). New, detailed snapshots capture photosynthesis at room temperature The living machinery responsible for photosynthesis – while commonplace and essential to life on Earth – is still not fully understood. It is understood at every level of…

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Controlled amino acid treatment of all pathology

November 22, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, Variations, What's in the News
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Amino acid studies.com Excerpt: One of the cancer treatments that seems to be proving effective over time is CAAT: Controlled Amino Acid Treatment. CAAT works by restricting certain amino acids from the diet to combat the growth and reproduction of the cancerous cells. Excerpt: doctors can now actively battle cancers, using the best weapons possible, natural amino acids, which are actually designed to make changes in the body. The trick has been to understand which changes are beneficial to cancer…

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Hydrogen-atom energy in DNA base pairs

September 19, 2016
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, Variations
One Comment

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Linking RNA structure to function

September 9, 2016
James Kohl
RNA Directed
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A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

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RNA methylation, behavior, and disease

June 11, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Epigenetics and Genetics of Viral Latency by Paul M. Lieberman (May 11, 2016)   My comment: Lieberman succinctly confirmed the fact that …viral latency is responsible for life-long pathogenesis and mortality risk… His simplistic conclusion also attests to the fact that there is no defined boundary between epigenetics and genetics. Epigenetic effects on metabolic networks must be linked to genetic networks via the energy-dependent innate immune system. That’s how all serious scientists knew they would need to link angstroms to ecosystems…

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Thermotolerance and longevity (2)

June 1, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See also: Thermotolerance and Longevity This article is part of the Research Topic Brain nutrient sensing in the control of energy balance: new insights and perspectives Excerpt: It is well established that nutrients act as signaling molecules in synergy with nervous and hormonal signals to inform the brain about the nutritional status of the body. The integration of these signals within the hypothalamus and other brain regions triggers behavioral and physiological responses through efferent autonomic nerves, hypothalamic-pituitary-Adrenal and thyroid axis…

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Virus-driven sex differences?

April 2, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Brain, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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DNA methylation on N6-adenine in mammalian embryonic stem cells Excerpt: DNA methylation is a crucial component of epigenetic regulation that controls many important aspects of mammalian biology, such as imprinting, X chromosome inactivation and tumorigenesis1, 2. My comment: Nutrient-dependent RNA-directed DNA methylation links RNA-mediated amino acid substitutions to protein folding chemistry during thermodynamic cycles of energy dependent protein biosynthesis and degradation. Sex of a baby? Ancient virus makes the call Excerpt: …in other organisms, such as C elegans and the…

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RNA-mediated theory killers (4)

December 19, 2015
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer Excerpt: At this moment, DNA methylation and non-coding RNA including with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) represent the largest body of available literature on epigenetic biomarkers with the highest potential for cancer diagnosis. My comment: The SLC19A3 microRNA was mentioned in the context of cancer and brain development in The impact of new technologies on clinical decision-making in health care. The location of the base…

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RNA-mediated theory killers (5)

December 18, 2015
James Kohl
Adaptations, Ecology, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, RNA Directed, Variations
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Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression Reported as: Researchers elucidate network of genes that control when puberty begins Excerpt: …have identified for the first time members of an elaborate superfamily of genes that regulate the timing of puberty in highly evolved nonhuman primates. My comment: Who do these researches and science journalists think they are fooling when they report the nutrient-dependent pheromone-controlled onset of puberty, which is obviously RNA-mediated, in the context of highly evolved organisms?…

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