viral latency

Protonated RNA interference vs stupid theories (1)

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 …microRNA maturation efficiency may be encoded in the intrinsic dynamic ensemble of primary and precursor microRNAs, providing a potential means of regulating microRNA biogenesis in response to environmental and cellular stimuli. See for comparison:  The landscape of host genetic factors involved in immune response to common viral infections 10/27/20 Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response…

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From optoribogenetics to HelioRiboGenetics (4)

The 2020 Nobel Laureates in Physiology or Medicine failed to link God’s Creation of energy-as-information in ultraviolet (UV) light and His Creation of water to biophysically constrained viral latency across kingdoms via oxidative phosphorylation and RNA interference. See for comparison: Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers 9/30/20 Conclusion The data indicate that PPMO have the ability to potently and specifically suppress SARS-CoV-2 growth and are promising candidates for further pre-clinical development. If the history of published…

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pH-dependent viral latency (2)

New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

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pH-dependent viral latency (1)

Four back-to-back articles in Science Magazine on May 15, 2020 attest to facts about how God’s Creation of energy-as-information was linked to all biodiversity on Earth via President Donald J. Trump’s claim about UV light and facts about light activated microRNA biogenesis, which biophysically constrains viral latency via the pH-dependent physiology of reproduction.   1) Modeling infectious disease dynamics The current pandemic has no parallel…, but the new virus is following rules common to other pathogens. The so-called “rules” are…

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The tipping point (revisited): 102K (1)

See first:  The tipping point (revisited): 101K (1) 4/22/20 and Vaccines do not control pandemics (1) 5/15/20 Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion 5/11/20 They linked virus-driven changes in light-activated energy-dependent differences in hydrogen-atom transfer in DNA base pairs in solution from microRNA flanking sequences to the degradation of messenger RNA and all obesity-linked diseases via changes in the potential of hydrogen (pH). See: Control of pH responsive peptide self-association…

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The tipping point (revisited): 100K (4)

The wisdom gap The resulting “wisdom gap” leaves us ripe for manipulation… unaware of threats and unprepared for dangers. And as science and technology push the bounds of the possible, the “wisdom gap” will render us increasingly unable to wrestle with how far those bounds should be pushed. Wrestle with this: Why is Oregon still on lock down? Many people want to believe our health authorities know what they’re doing. Intelligent serious scientists know that our health authorities are corrupt.…

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The tipping point (revisited): 100K (3)

More than 100,000 indexed published works that mention microRNAs link the Creation of anti-entropic virucial light from light-activated microRNA biogenesis to RNA-mediated autophagy via the physiology of reproduction and biophysically constrained viral latency in all living genera. See for review: The tipping point (revisited): 100K (1) at MicroRNA-mediated.pro See for review: The tipping point (revisited): 100K (2) at Autophagy.pro Moving forward to what is known about how microRNAs are linked from RNAs to healthy longevity see: Autophagy regulation by microRNAs:…

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Information Wars started by medical practitioners (1)

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (Apr 11, 2018) My Summary: The pheromone-controlled physiology of reproduction biophysically constrains viral latency and the transgenerational epigenetic inheritance of healthy longevity in the context of fixation of the EDAR V370A variant. The variant links changes in a single base pair to differences in an amino acid substitution, which links the mouse-to-human model of ecological adaption from microbes to all extant morphological and behavioral biodiversity. See for comparison: Biological Networks: An Introductory…

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Natural models inspire future therapeutics (2)

Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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Predicting naturally occurring viral latency

KLRD1-expressing natural killer cells predict influenza susceptibility We identified KLRD1-expressing NK cells as a potential biomarker for influenza susceptibility. Expression of KLRD1 was inversely correlated with symptom severity. Our results support a model where an early response by KLRD1-expressing NK cells may control influenza infection. The NK cells are natural killer cells that help to control viral latency This was reported as: Scientists discover biomarker for flu susceptibility  “We found that a type of immune cell called a natural killer…

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