viral microRNAs

Mystery machine vs model

See: Mystery machine vs medical intelligence Is nutrition the future of brain health? Excerpt: Steindler’s focus on the link between nutrition and neurodegenerative diseases is unique in the field. My comment: If he has limited his claims to those associated only with neurodegenerative diseases, his focus is too narrow. Unfortunately, narrow focus is common among specialists. Their focus makes them specialists, and without them generalists could not connect the specialties to healthy longevity and/or pathology. Not just brain health or…

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Epigenetic inheritance of stress-perturbed protein folding

Sperm RNAs Transmit Stress Re: Bale’s group will next try to identify epigenetic changes in embryos that might allow miRNA changes to have an effect in adult animals. Nutrient-dependent microRNAs are the link from viral microRNAs to transgenerational epigenetic inheritance of morphological and behavioral phenotypes. The nutrient-dependent microRNAs typically protect organized genomes from DNA damage linked to the theft of nutrient-energy. The energy theft by viruses links entropic elasticity to genomic entropy, which links viruses to all pathology in the…

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Preventing genomic entropy

Tethering Transposons Excerpt: Transposons—thought to be related to viruses—can copy themselves and insert randomly around the genome. A paper published today (October 15) in Science provides a greater understanding of how cells shut down these rogue jumping genes. My comment: Shouldn’t someone else be claiming that nutrient-dependent microRNAs prevent the accumulation of viral microRNAs that leads to perturbed protein folding, which links mutations to all pathology in the context of an atoms to ecosystems model? Nutrient-dependent pheromone-controlled ecological adaptations: from atoms…

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Cancer: forward and reverse

The convergent cancer evolution toward a single cellular destination Abstract excerpt: …cancer evolution is a directional process toward a defined cellular destination, a finding reconciling development and evolution, the two seemingly incompatible philosophies both adopted by the cancer research community, and also raising new questions to evolutionary biology. My comment: The idea that cancers evolve and the idea that species evolve are not compatible. Taken  together, the incompatible ideas that have been adopted by cancer researchers led to 32 years…

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Let there be anti-entropic light (2)

Predicted Inactivation of Viruses of Relevance to Biodefense by Solar Radiation (2005)Excerpt: Sunlight or, more specifically, solar UV radiation (UV) acts as the principal natural virucide in the environment. UV radiation kills viruses by chemically modifying their genetic material, DNA and RNA. See also: Let there be anti-entropic light (1) Excerpt: Nutrient-stress and social stress contribute to the accumulation of viral miRNAs that would typically be prevented by nutrient-dependent pheromone-controlled feeback loops that link food odors and social odors to…

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Do young neurons in the brain evolve?

Brain Gain Young neurons in the adult human brain are likely critical to its function. By Jef Akst | October 1, 2015 Excerpt “The rate at which [new neurons] incorporate is dependent upon experience,” Gage says. My comment: The experience-dependent de novo creation of olfactory receptor genes is the basis for the following representation of biologically-based cause and effect: Feedback loops link odor and pheromone signaling with reproduction Virus-perturbed nutrient-dependent RNA-mediated protein folding biochemistry is the clearest link from nutrient-stress…

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Mechanisms of stress: from genes to cancer

Biophysically constrained nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation link the epigenetic landscape to the physical landscape of DNA in all living genera. Genomic stability arises in the context of a fine-tuned balance of viral microRNAs and nutrient-dependent microRNAs.  RNA-mediated gene duplication and RNA-mediated amino acid substitutions stabilize organized genomes. Nutrient-dependent microRNAs are linked by RNA-mediated amino acid substitutions from ecological variation to protection from DNA damage caused by viral microRNAs. The microRNA/messenger RNA balance links ecological variation to…

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Viruses come alive: Tree of life pseudoscience

See also: The creation and activation of GPCRs ‘Tree of life’ for 2.3 million species released This comment was removed from a “tree of life” discussion site by the “site staff.” In the context of anonymous “peer” review, the comment was removed for the following reason: PSEUDOSCIENCE, with an added threat that my account might be suspended in case of regular violations of the guidelines that led the “site staff” to remove this comment. Young earth creationists addressed the “Tree…

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Genome sequencing, cadherins, and quantum consciousness

Brave new epigenomes: the dawn of epigenetic engineering Reported as: Opinion: Engineering the Epigenome Excerpt: . ..until recently, we were not able to assess the influence of individual marks on gene activity because it was only possible to alter chromatin marks globally through mutational approaches or pharmacological inhibition. My comment: Mutational approaches led to assumptions about cell type differentiation that failed to include the role of viruses, viral microRNAs,  and the nutrient-dependent microRNAs that prevent the accumulation of viral microRNAs…

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“New” quantum biology. Pirating the old

Jim Al-Khalili is a nuclear physicist. Luca Turin is a biologist. Both presenters link Schrödinger’s claims in What is Life? Which one knows most about it? Jim Al-Khalili  frames his presentation in the context of evolutionary theory. See the text or the 20-minute Video presentation: Jim Al-Khalili: How quantum biology might explain life’s biggest questions Luca Turin frames his presentation in the context of what is known to serious scientists about the biophysically constrained chemistry of nutrient-dependent RNA-mediated protein folding. See also: …

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