viral replication

MicroRNA-mediated population control (9)

See first: MicroRNA-mediated population control (8) 8/6/21 Light-activated microRNA biogenesis and peptide synthesis at the origin of life link biophysical constraints on the 2nd Law of thermodynamics  to microRNA-mediated biophysically constrained viral latency in all model organisms. Added support for the facts were published on 8/11/21. See: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients The facts were reported as: Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication…

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microRNA-mediated election cycles (3)

See: microRNA-mediated election cycles (2) The most recent addition to the 124,062 indexed published works that mention ‘microRNA’ is A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine For background on this paradigm shift, see the following works: US Air Force Studying Impact of Exome Sequencing in Routine Care 10/19/17 The special considerations around fitness for duty and privacy make this a particularly challenging study to design and implement, but also an extremely important…

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microRNA-mediated replication timing (3)

miRNAs; a novel strategy for the treatment of COVID-19 6/28/21 Several previous studies have shown that host miRNAs play an anti-viral role and improve the treatment of patients with COVID-19. miRNAs by binding to the 3′-UTR or 5′-UTR of viral RNA play an important role in COVID-19-host interplay and viral replication. That fact makes it easier to convict Facebook of crimes against humanity because their censors prevent me from including links to autophagy.pro, and to microRNA.pro which expose the scientific…

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Plenty of Room at the Bottom

CDC’s ignorance: from roots to shoots (3)

Longtime AIDS researcher Robert Redfield picked to lead CDC 3/21/18 In the early days of the AIDS crisis, Dr Redfield…[failed to learn about biophysically constrained] …active HIV replication in all stages of HIV infection. All viral replication is energy-dependent and microRNA-mediated. Without realizing it, the director of the CDC linked food energy-dependent pheromone-controlled fixation of amino acid substitutions from virulence in HIV-1 to less virulence in HIV-2. See: Correlation of Antibody Responses to a Peptide Antigen gp120-C5501–512/gp41732–744 with HIV Disease Progression 6/1/17…

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Food energy-dependent epigenetic adaptation

Mechanism of transmembrane signaling by sensor histidine kinases, was reported as Scientists investigate how the sense of smell works in bacteria …the signaling and inactive states differ only very slightly at the nitrate-binding site – by 0.5-1 angstroms, which is approximately one fifth of the size of the ion itself (1 angstrom is 10-10 meters). However, when this ion binds to the sensor, it causes huge changes in the protein: The helices of different monomers begin to move in different…

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Viruses in pathogenic variants disrupt alternative splicings (2)

Autophagy is activated by virus-driven energy theft. Click on the term “Autophagy” That fact is clear in the diagram of systems complexity and in my model. See for contrast:  Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors A key question in virology, that is potentially answerable using paleovirological analyses, is what caused the elimination of extinct viral lineages? Conclusion: The selection pressures acting on hsaHTenv, its orthologs and progenitors might have been complex. Loss of fusogenicity…

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Conserved biophotonic emissions

Human high intelligence is involved in spectral redshift of biophotonic activities in the brain The tendency of the spectral redshift of glutamate-induced biophotonic emissions in this study is in the order of frog, mouse, chicken, pig, monkey, and human, which is almost consistent with the phylogenetic tree. Although the present imaging technique could not distinguish and determine what types of neurons emit what types of spectral biophotons or whether a neuron or type of neurons emit different spectral biophotons, we…

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Masters of deception about nature (2)

See my other blog posts on RNA methylation Thanks for your review of How Can Physics Underlie the Mind?: Top-Down Causation in the Human Context (The Frontiers Collection) Others linked the sun’s anti-entropic virucidal energy from energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects all organized genomes from virus-driven energy theft and genomic entropy. Ellis comments on at least one of Schrodinger’s claims from “What is Life?” but he largely ignores the…

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Microbes to humans 2015 Nobel Prize

3 Scientists Win Nobel Prize in Medicine for Parasite-Fighting Therapies Excerpt 1) Success in antimalarial therapy depends on how clever scientists are in using combinations of drugs. Excerpt 2) Dr. Omura played down his accomplishments, saying, “I merely borrowed the power of microbes.” My comment: These two excerpts appear within the context of three paragraphs that clearly link RNA-mediated cell type differentiation in species from microbes to humans. The context attests to what at first may appear to be a…

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