virus-driven degradation of messenger RNA

Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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The concept of a species (1)

In an attempt to discuss The misleading evidence that fooled scientists for decades I wrote: The concept of a species is clearly seen in the context of Darwin’s “conditions of life” and sympatric speciation. What organisms eat is linked from their physiology of pheromone-controlled reproduction to biophysically constrained viral latency and all extant biodiversity via energy-dependent changes in base pairs and fixation of amino acid substitutions in the organized genomes of species from microbes to humans. See Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From…

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http://www.sciencedirect.com/science/article/pii/S0303264717302782 open access

Biologically uninformed science idiot: Self-defense (1)

I recently published a review of nutritional epigenetics. It was an invited review that was returned in 2014 without review so I placed it on a preprint server as: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems In the past 4 years, others have linked the creation of subatomic particles from quantum physics to classical physics. Now, the slight change in the title makes more sense.  See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems The review already is forcing biologically…

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The eternal significance of microRNAs and the Vietnam Memorial (2)

Summary: Quantized energy as information has been linked from what organisms eat to biophysically constrained membrane protein construction in the context of viral latency and healthy longevity. Cryoelectron microscopy (aka electron cryomicroscopy for obfuscation) clearly links what is known about the virus-driven degradation of messenger RNA to all pathology or from energy-dependent RNA-mediated DNA repair to species survival. Membrane Proteins – Richard Henderson May 31, 2018 Energy as information and biophysically constrained membrane protein construction – James Kohl Feb 15,…

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From quantum physics to quantum souls (5)

Three recently published articles attest to the eternal significance of prior works that linked quantum physics to quantum souls via what  is known to all serious scientists about Energy as information and constrained endogenous RNA interference (February 15, 2017) See 1) Photosynthetic Energy Transfer at the Quantum/Classical Border June 2018 See also 2) Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system May 28, 2018 Switchable photosynthetic organelles may enable the development of biomimetic vesicle systems with regulatory…

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The eternal significance of microRNAs (9)

Ancient origins of viruses discovered …many of the viruses infecting us today have ancient evolutionary histories that date back to the first vertebrates and perhaps the first animals in existence. Viruses do not have evolutionary histories. They adapt to hosts by stealing the quantized energy that is required for fixation of RNA-mediated amino acid substitutions in organized genomes. For example, a report of fixation of one amino acid substitution in the influenza B virus, forced denuclearizaton in North Korea. God-less…

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The eternal significance of microRNAs (5)

Excerpt: Researchers in South Korea, for example, have reminded the God-less Communist dictator of North Korea that one microRNA-mediated amino acid substitution in the influenza B virus could decimate the human populations that he thinks he rules. Conclusion: Conserved energy biophysically constrains viral latency. Ridiculously ignorant objections to my publication in what others claim is a predatory journal can be compared to my objection to publication of this article in PNAS. Environmental selection during the last ice age on the…

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Ecological adaptations vs the randomness of evolution (3)

Summary: Fifty years later, only theorists and other pseudoscientists have failed to recognize the facts that link experimental evidence of differences in the energy of photons to the proton motive force, which links the potential of hydrogen (pH) to biophysically constrained viral latency and all biodiversity on Earth. In that context, Carl Zimmer serves as an important example of human idiocy each time he makes claims about evolution. Serious scientists will meet during Schrödinger at 75 – The Future of…

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EDAR V370A and sympatric speciation

Nick Lane and others like him refuse to reappraise their human mitochondrial DNA recombination dogma. All serious scientists know where the energy for recombination comes from. But, in his latest video clip, he touts the same unsubstantiated theoretical pseudoscientific nonsense. See the: Aeon Video: Life on earth – from mushrooms to humans and everything in between – seems enormously diverse. At the cellular level, however, almost all complex lifeforms are surprisingly similar. Why life is this way, though, remains mysterious.…

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MicroRNA-mediated autophagy, denuclearization and eusociality

Altruism in a volatile world reported as: The Elusive Calculus of Insects’ Altruism and Kin Selection In 1964, the evolutionary biologist William D. Hamilton seemingly explained one of the greatest paradoxes in biology with a simple mathematical equation. He will be remembered by all serious scientists for his ignorance of top-down energy-dependent causation. For comparison, McEwen et al. (1964), explained energy-dependent ecological adaptation and sympatric speciation by starting with the energy-dependent creation of RNA. See: Dependence of RNA synthesis in…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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