Virus-driven energy theft

An evolutionary theory killer

Epigenetic inheritance of spatiotemporal regulation (5)

May 25, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations
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Thanks for the Stress, Dad As embryos, the researchers found that the mouse offspring, which exhibited more anxious behavior than usual, also had lower miRNA levels, as did the sperm of the male offspring upon maturity. The stress-linked degradation of messenger RNA is caused by virus-driven energy theft, which has been linked to all pathology in species from bacteria to humans.  For example: Neutrons identify critical details in bacterial enzyme implicated in gastric cancer Ronning’s team focused on H. pylori’s…

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The eternal significance of microRNAs (10)

May 16, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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ETERNAL:  lasting or existing forever; without end or beginning. SYNONYMS everlasting, never-ending, endless, perpetual, undying, immortal, abiding, permanent, enduring, infinite, boundless, timeless IN CONTEXT (of truths, values, or questions) valid for all time; essentially unchanging EXAMPLE: eternal truths of art and life” EXAMPLE:  The Vietnam Veterans Memorial Wall is a wall of eternal significance. The parents of the architect left China before the Communist take-over. Scientific creationists from South Korea have since linked the efforts of the US Military forces…

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For God and Country

Faith in evolution: Paleontology as a molecular science

October 16, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic
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Keeping the faith For the last 20 years, Mary Schweitzer, a paleontologist at North Carolina State University in Raleigh, has amassed a wealth of evidence that she’s isolated protein fragments from dinosaurs as much as 80 million years old. That bucks the conventional wisdom among paleontologists who argue that proteins, which are made of chains of amino acids, can’t survive more than 1 million years or so. So far, no group other than Schweitzer and her collaborators has managed to…

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Lethal virus kills 5 billion people?

Until death: Virus-driven failure of multisensory integration (2)

October 10, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Human Brain, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: The virus-driven degradation of messenger RNA is clearly linked to frontotemporal dementia (FTD) by altered language, personality, behavior, cognition and motor function. What causes FTD? If the virus-driven degradation of messenger RNA causes all pathology, I would expect to find a link from microRNAs to the pathology and to the effective treatment. The social and economic burden of frontotemporal degeneration Reported as: Study reveals staggering economic burden of dementia in younger people Frontotemporal degeneration (FTD) accounts for 20 to…

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Thanks again for asking about DNA methylation

October 2, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Human Brain, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA-directed DNA methylation, Variations, What's in the News
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Re: RNA-directed DNA methylation (1996) See: From Fertilization to Adult Sexual Behavior Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. See also: RNA-directed DNA methylation: an epigenetic…

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Pseudoscientists hate what science explains! (3)

August 17, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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See also: Pseudoscientists hate what science explains (2) Summary: In addition to germline silencing via information transfer to the physical landscape of supercoiled DNA, multicopy transgene arrays are linked from changes in the microRNA/messenger RNA balance to variation in their somatic expression level. That fact helps to establish the difference between healthy longevity and pathology across generations. Problems with DNA replication can cause epigenetic changes that may be inherited for several generations My summary: The polycomb repressive complex 2, additional…

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Energy and neural plasticity

August 16, 2017
James Kohl
Adaptations, Alternative Splicings, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity
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Summary: Food energy is required because proteins do not create themselves and virus-driven energy theft causes the degradation of messenger RNA in all living genera. See for comparison: Neural plasticity wanes with age, but increasing the protein Arc—abundant earlier in life—in the visual cortex of mice can fend off this decline. The restoration of neural plasticity requires the food energy-dependent pheromone-controlled de novo creation of genes. For example, see: Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees Desperate…

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Your indifference is killing you and others

August 16, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, Variations
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Summary: Coherence-inducing mechanisms is double-speak for mechanisms that are nutrient-dependent and pheromone-controlled. Feedback loops link odor and pheromone signaling with reproduction has been presented in double-speak as Looplessness in networks is linked to trophic coherence We are currently studying the entropy of the coherence ensemble we defined for this work. “In general, higher trophic coherence would be associated with lower entropy states, which means that if networks are more coherent than the random expectation there must indeed be some kind…

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The Origin of Information (4)

August 4, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: Others have learned that the energy in a hydrogen atom must be linked to all biodiversity on Earth. The question is: “Where did the energy in the hydrogen atom come from?” See: The Origin of Information (3) Finally, someone is asking questions that can be summarized in one question (see below). Until now, on the International Society for Human Ethology’s Yahoo group, and elsewhere, the moderator: Jay R. Feierman has prevented the dissemination of accurate information on this topic.…

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Energy-dependent physical and biophysical constraints (9)

July 28, 2017
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated gene silencing, Variations, What's in the News
One Comment

Summary: Energy determines genome compaction because activity in the nucleus is energy-dependent. Chromatin chains link energy-dependent changes in base pairs from single nucleotide polymorphisms to fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of pheromone-controlled reproduction. It’s all about the base. Energy-dependent physical and biophysical constraints (8) ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells Excerpt 1) The chromatin structure of DNA determines genome compaction and activity in the nucleus. My comment:…

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