virus-driven

Naturally attenuated viral endemicity (8)

See first: Naturally attenuated viral endemicity (7) “MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly 11/19/21 …we describe a new role for miR-101-3p as a modulator of mitochondrial metabolism via its regulation of multiple mitochondrial processes, including mtDNA transcription and complex II biogenesis.” See also: Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function 11/24/21 Exposure to long wavelength light (650–900 nm) in animals improves mitochondrial function, increasing ATP production and…

Read More

Did evolution autophosphorylate your kinases? (3)

Did evolution autophosphorylate your kinases? (1) Did evolution autophosphorylate your kinases? (2) See also: N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection Reported as: Chemical tags affect ability of RNA viruses to infect cells Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Reported as:  Zika virus infection alters human and viral RNA My comment: Virus-driven hecatombic evolution of all pathology is linked from the failure of energy-dependent phosphorylation to biophysically constrain the RNA-mediated damage to DNA via…

Read More

Did evolution autophosphorylate your kinases? (2)

Hecatombic evolution Deep-Sea Viruses Destroy Archaea Excerpt: Given the enormous scale of deep-sea ecosystems, the results indicate that archaea-virus relationships could be a major contributor to global biogeochemical cycles. My comment:  I know that Anna Di Cosmo​ and John Hewitt​ are able to link virus-driven energy theft to all pathology in all living genera via the conserved molecular mechanisms they have already placed into their proper perspective on natural selection for energy-dependent codon optimality, which links the innate immune system…

Read More

GC-rich neo-Darwinian train wreck

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells Excerpt: In this study, we demonstrate direct cellular reprogramming to induced neuronal cells through targeted activation of endogenous genes. Excerpt: Moreover, a recent study demonstrated that reprogramming efficiency can be limited by divergence to a competing cell identity (Treutlein et al., 2016). The molecular mechanisms and practical consequences of these limitations are largely unknown. My comment: They demonstrate what naturally must occur to link…

Read More

Energy-dependent biodiversity (3)

Higher Abundance of Bacteria than of Viruses in Deep Mediterranean Sediments Conclusion: Results obtained in this study suggest that the number of viruses in deep-sea sediments might be dependent upon complex interactions with both abiotic factors (such as pressure, physical disturbance, and redox conditions) and biotic factors, including bacterial metabolic state and virus supply from the water column. Further studies are needed to clarify the causes of the low viral density, to estimate the actual impact of viruses on benthic…

Read More

Virus-driven disorder prevention and health promotion

The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion Excerpt: Evidence has also been growing about the role of epigenetic modification in response to the social environment. My comment: Unexpectedly, Szyf et al., (2016) fail to mention all the evidence of epigenetically-effected RNA-mediated cause and effect that has accumulated since we published our 1996 Hormones and Behavior review. That may explain why they also failed to link energy-dependent hydrogen-atom…

Read More

Soil bacteria, bulls, cows, microRNAs, and mammary glands

What is Life? Excerpt:  Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight) My comment:…

Read More

Models of scientific literacy

Scientific Literacy Redefined Researchers could become better at engaging in public discourse by more fully considering the social and cultural contexts of their work. By Cynthia Brandenburg | February 1, 2016 Excerpt: …any truly productive conversation about why their fears are scientifically unfounded must be predicated upon an understanding of what caused those fears in the first place. My comment: “A Fear of Pheromones” led many researchers to ignore the fact that metabolic networks must be linked to genetic networks…

Read More

Did Dobzhansky see the UV light of creation?

Analemma. The sun’s position in the sky, photographed from the same location at the same time of day throughout a year, forms an analemma. This shows the sun’s apparent swinging from its northernmost position, at the analemma’s uppermost point, at summer solstice, to its southernmost position/lowest point, at winter solstice. My comment: Does this remind anyone else of a one-sided nonorientable surface obtained by cutting a closed band into a single strip with linked ends that can be used to…

Read More

Sensationalizing no new mechanism

Scientists discover new mechanism that protects brain stem cells against aging-induced damage Excerpt: Sebastian Jessberger says: This is an exciting new mechanism involved in stem cell division and aging. But as of now we are only just beginning to understand the molecular constituents and the true meaning of the barrier for stem cell division in the brain. One key question to be answered is whether the barrier is established in all somatic stem cells of the body. My comment: There…

Read More