Ricki Lewis’ Time Machine (4)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

Read More

RNA-mediated silencing of a chromosome

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3was reported as: How an RNA gene silences a whole chromosome Summary: “Researchers have discovered how an abundant class of RNA genes, called lncRNAs can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group of proteins and ultimately prevents women from having an extra functional X-chromosome — a condition in female embryos that leads to death in early development.…

Read More