Re: RNA-directed DNA methylation (1996) See: From Fertilization to Adult Sexual Behavior
Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes.
See also: Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity (2017) reported as: Humans and sponges share gene regulation
Reported 10/2/17 as: Unexpected findings uncover new understanding of gene expression
What is it about the whole body of the enzyme itself that functions in development and its mutations that can result in cancer?
Thanks again for asking. It is the fact that RNA-directed DNA methylation is energy-dependent and the fact that virus-driven energy theft causes the degradation of messenger RNA, which serious scientists have linked to all pathology.
Everything known to serious scientists about energy-dependent increasing organismal complexity has been portrayed by pseudoscientists in the context of mutation-driven evolution.
The pseudoscientists are not going to stop until serious scientists force them to start helping those who are “Combating Evolution to Fight Disease.”
See for comparison: Relating protein functional diversity to cell type number identifies genes that determine dynamic aspects of chromatin organisation as potential contributors to organismal complexity
…there is evidence that some of the selected genes may contribute to the formation of different cell types. One route might be through the modification of stem cell activity in response to a greater functional diversity of the proteins that modulate epigenetic status to either maintain or promote differentiation [35,36].
Beneath the surface of what you see reported about organismal complexity in the mainstream media, you can see: Eligo Bioscience Secures $20 Million Series A from Khosla Ventures and Seventure to Bring Precision Medicine to the Microbiome
A growing body of research shows that the microbiome, made up of the ten trillion bacteria residing within and on the human body, sits “at the interface of health and disease.”
The company’s approach uses the innate immune system of bacteria (CRISPR) to edit the genetic material of antibiotic-resistant bacteria. The microRNAome links the virus-driven degradation of messenger RNA in bacteria from the energy-dependent pheromone-controlled physiology of reproduction to all pathology biodiversity via changes in the healthy microbiome. The concept of endogenous RNA interference is rapidly replacing the nonsense about virus-driven gene editing, which has not yet earned a Nobel Prize for pseudoscientific representations of cause and effect.
MicroRNA present in mature sperm appears to not only be left over from spermatogenic processes, but may actually serve important regulatory roles in fertilization and early developmental processes. Further, our results indicate the possibility that environmental changes may impact the expression of specific miRNA.
This is what one of my former Facebook friends called “bullspit.” It is about “bull sperm.” It is not what other former Facebook friends say “nobody cares” about. It is the link from energy-dependent changes in soil bacteria to all biophysically constrained life on Earth. It is also what other researchers who are biologically uninformed science idiots tell you is the link from virus-caused mutations to evolution.
See for comparison: Cytosis: A Cell Biology Board Game
A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!
See for comparison: Nobel Prize in Medicine Awarded to Circadian Rhythm Researchers
I do not expect anyone who has not already linked what is known about quantum physics to quantum souls to understand why this year’s Nobel Laureates in Physiology or Medicine have abandoned all experimental evidence of biophysically constrained top-down causation to continue touting their ridiculous gene-centric theories.
Do you? But, I understand why they do not want to admit to the facts.
…when they controlled for other trauma types, military-related trauma was the only trauma type that was uniquely associated with eating disorder symptoms. Examination of different types of military-related trauma indicated that the association was not driven by exposure to combat.
Predictably, it was an exposure-driven association with the stress-linked failure to adapt to virus-driven changes in gut microbiome and behavior that lead veterans who have served overseas to commit suicide.
Reported as: The dust storm microbiome
The researchers found that during a dust storm the concentration of bacteria and the number of bacterial species present in the atmosphere rise sharply, so people walking outdoors in these storms are exposed to many more bacteria than usual.
Greg Bear put this into the perspective of Homeland Security in his techno thriller “Quantico.” At times, all that serious scientists can do is laugh about the pseudoscientific nonsense touted by theorists. Bear checked the facts from “Darwin’s Children” with me before he sent the manuscript for publication. And then came this interview with Jon Stewart.
For example: “Y/Our Vocal Sounds – Towards an Ethological Classification of Human Vocalizing Behavior and Sounds
by Jay R. Feierman
This article is a first attempt at an ethological classification of human vocalizing behaviors and the sounds they make. Lastly, how human ethologists could study these two different types of human vocalizing behaviors, using the sounds they make as proxies, will be discussed.
Summarized in part in Ourselves Explained link opens pdf
A Review of the book
THE SECRET OF OUR SUCCESS. HOW CULTURE IS DRIVING HUMAN EVOLUTION, DOMESTICATING OUR SPECIES, AND MAKING US SMARTER By Joseph Henrich. 2016
The key to this book’s 18-word title can be summed up in five: Cumulative culture drives
The failure of this book to explain any aspect of biophysically constrained biologically-based cause and effect can be summed up in seven words. No species evolved from any other species.
Energy-dependent RNA-directed DNA methylation links ecological variation from biophysically constrained viral latency to all biodiversity via the physiology of pheromone-controlled reproduction in species from microbes to humans.