Exploring the Impacts of Genetic Variation on Tissue-Specific Expression

Preliminary results from the Genotype-Tissue Expression project reveal that gene expression varies more across tissues than across individuals.

By Jenny Rood | May 7, 2015

Excerpt:

“You’ve got the genetic variation, you’ve got the gene expression levels, you’ve got the different tissues…”

My comment: What you don’t have is a model of RNA-directed DNA methylation and RNA-mediated amino acid substitutions that links the epigenetic landscape to the physical landscape of DNA in the organized genomes of all genera via the fixation of the amino acid substitutions in the context of the nutrient-dependent physiology of reproduction. I have that!

See: Environmental Epigenetics and a Unified Theory of the Molecular Aspects of Evolution: A Neo-Lamarckian Concept that Facilitates Neo-Darwinian Evolution and Nutrient-dependent/pheromone-controlled adaptive evolution: a model  for comparison of theory and biologically-based facts about RNA-mediated cell type differentiation.

Alternatively, see Mutation-Driven Evolution, which concludes: “…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world. In this view of evolution there is no need of considering teleological elements” (p. 199).

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