See first: Coherently organized healthy longevity (4)

UV light, H2O, and epigenetic effects affect behavior and sympatric speciation

Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics​​ Moderator Tony Kouzarides

Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation

James V. Kohl*

MicroRNA.pro

Introduction

UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic.  For a historical perspective, see

1) Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”, 1

2) Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene, 2

3) Nutrient–dependent / pheromone–controlled adaptive evolution: a model, 3

4) Why have microRNA biomarkers not been translated from bench to clinic? 4

 

Abstract

Energy-dependent microRNA-mediated changes in angstroms to ecosystems5 link biophysically constrained viral latency from quantum coherence to coherently organized biology6 via femtosecond blasts of ultraviolet (UV) light. Moderate amounts of UV light link differences in DNA damage to  microRNA-mediated DNA repair.6-8 For instance, “…plants alter microRNA (miRNA) biogenesis in response to light transition.”9

In species from microbes to mammals, food energy-dependent pheromone-regulated genetic processes link feedback loops from energy as information to biophysically constrained RNA-mediated protein folding chemistry via RNA abundance and RNA interference, which is required for microRNA-mediated DNA repair. 1, 10-11

The National Microbiome Initiative links what mammals eat from microbial quorum sensing in the gut to the physiology of  pheromone-regulated genetic process and reproduction via endogenous RNA interference and chromosomal rearrangements.12  Fixation of RNA-mediated  amino acid substitutions links naturally occurring light-activated carbon fixation  to energy-dependent chromosomal rearrangements.

Natural selection for energy-dependent codon optimality13 links the Precision Medicine Initiative to genome- wide details of how chromosomal rearrangements  are linked to the Creation of genotypes. For instance, the chromosomal rearrangements  link everything currently known about classical physics to chemistry via  achiral glycine in postition 6 of the gonadotropin releasing hormone decapeptide (GnRH) in jawed vertebrates.14

The biophysically constrained GnRH decapeptide hormone links molecular epigenetics from what is known about bacteria to exquisitely fine-tuned autophagy across kingdoms. For comparison, constraint-breaking mutations are linked from the viral hecatomb15 to the mutation-driven evolution of pathology.16

Detailed representations of energy-dependent natural selection for codon optimality have consistently linked biologically-based cause and effect from the energy-dependent Creation of enzymes and G protein-coupled receptors to fixation of RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. 17

Light-activated 18 energy-dependent polycombic ecological adaptations 19 are manifested in supercoiled DNA. Chromosomal inheritance links the ecological adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes and transgenerational epigenetic inheritance.8

For contrast, virus-driven energy theft links the degradation of messenger RNA to negative supercoiling, constraint breaking mutations, and the hecatombic evolution of all diseases.  Indeed, the viral hecatomb links transgenerational epigenetic inheritance in archaea to coronavirus-damaged DNA in humans, which typically is repaired by  food energy-dependent endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.20

Conclusion:

Theorists who ignore the role of nutrition in biophysically constrained viral latency are largely to blame for all extant diseases. 21 See for instance: The Secret Language of Cells: A New Paradigm for Understanding Health and Disease. 22 See for comparison: MicroRNAs: Genomics, Biogenesis, Mechanism, and Function. 23

References

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  2. Skalsky, R. L.; Cullen, B. R., Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene. PLoS One 2011, 6 (9), e24248.
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