Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain


The RNA-seq data enabled us to detect a positive correlation between developmental changes in the magnitude of parental biases and overall gene expression for most imprinted genes.

At the level of the organism, our data uncover how paternal and maternal alleles of Bcl-x make vastly different contributions to brain development, a result that has profound implications for the analysis of parentally-inherited polymorphisms in human health.

Reported as:

Expanding the brain: Research identifies more than 40 new imprinted genes

See also: The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

The experience-dependent variant links what is known about the biophysically constrained chemistry of nutrient dependent RNA-mediated protein folding to imprinted cell types via amino acid substitutions that determine cell type differences in all cell types of all individuals of all organisms.

In this context, it has become clear that Every amino acid matters.

The physiology of reproduction links germ cells to somatic cells and to morphological and behavioral differences in the sexes during thermodynamic cycles of protein biosynthesis and degradation, which are perturbed by viruses. The viruses perturb the nutrient-dependent RNA-mediated events that link the fixation of amino acid substitutions to the stability of all organized genomes.

See also: Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

The complexity of virus-driven entropic elasticity, which is modulated by the anti-entropic epigenetic effects of nutrient-dependent microRNAs, has been placed into the context of mutations and evolution by biologically uninformed theorists. Catherine Dulac is not one of them

For comparison, PZ Myers is a biologically uninformed theorist who attacked Nathaniel Jeanson, a Harvard-educated Ph.D

See: A first-hand report of Nathaniel Jeanson’s lecture in Boston


As I told Catherine Dulac, his former dept. head at Harvard, it was an hour-long spectacle of misinformation, half-truths and what appeared to be deliberate obfuscation.

As is typical of PZ Myers and others who are equally biologically uninformed, he lets others attack. Then, Myers asserts his superior knowledge in the context of what he thinks is their superior knowledge.

He does not support his claims with experimental evidence of biologically-based cause and effect because he is not a scientist. He is an atheist blogger and is, or was, a biology teacher. If he were a serious scientist, PZ Myers would know that the link from Jeanson’s claims to the reports from Dulac on experience-dependent receptor-mediated differences in imprinted genes, cell type differences, and morphological and behavioral phenotypes can be placed into the context of virus-driven genomic entropy.

Genomic entropy is prevented by the nutrient-dependent de novo creation of olfactory receptor genes. RNA-mediated gene duplication and nutrient-dependent RNA-mediated fixation of amino acid substitutions links viruses and mutations to olfactory receptor gene loss. Nothing links mutations to the gain of structures or functions except the pseudoscientific nonsense of neo-Darwinian theory and the vague claims of the biologically uninformed.

For comparison, the light-induced de novo creation of amino acids links the creationist Biblical perspective from “Let there be light” to nutrient-dependent RNA-mediated amino acid substitutions that differentiate cell types via the experience-dependent de novo creation of olfactory receptor genes. Virus perturbed protein folding links mutations to the loss of olfactory receptor genes when they are no longer needed to support the organism-level genomic stability that is required for successful reproduction of all species.

The accumulation of viral microRNAs continues if it is not prevented by nutrient-dependent microRNAs that control the finely-tuned microRNA/messenger RNA balance. The nutrient-dependent microRNA/messenger RNA balance controls RNA-mediated cell type differentiation.

Neo-Darwinian theorists inadvertently placed the nutrient-dependent microRNA/messenger RNA balance into the context of mutations and evolution. Simply put, they ignored Darwin’s ‘conditions of life’ and removed nutrient-dependent RNA-mediated events from any further consideration whatsoever — before anything was known about RNA-mediated events. Fortunately, now that serious scientists are beginning to understand how cell type differentiation occurs, the neo-Darwinian theorists may soon be  stopped from presenting any more pseudoscientific nonsense.

See, for instance, Eugene Koonin’s recent claim:


Can biologically uninformed science idiots like PZ Myers continue to retard scientific progress. Yes, history has a way of repeating itself when anyone challenges the dogma of pseudoscientists.

See for example:

Description: Elaine Morgan was a tenacious proponent of a theory that is not widely accepted. The aquatic ape hypothesis lays out the idea that humans evolved from primate ancestors who dwelt in watery habitats. Hear her spirited defense of the idea — and her theory on why science doesn’t take it seriously.

See also: “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.” ( p. 127)

If you place Dobzhansky’s claim into the context of the claim that Every amino acid matters, but try to link the claims of theorists to Mutation-Driven Evolution, do not expect serious scientists to take you seriously. Serious scientists are too busy Combating Evolution to Fight Disease.


The evolutionary biologist Theodosius Dobzhansky famously noted that “nothing in biology makes sense except in the light of evolution,” but perhaps, too, “nothing in evolution makes sense except in the light of biology.” Although the latter might be an exaggeration, an important gap is being filled by molecular understanding of the genesis of variation that confers the ability to evolve.

The anti-entropic energy of nutrients confers the ability to ecological adapt. Ecological speciation arises via the fixation of RNA-mediated amino acid substitutions and chromosomal rearrangements during the life history transitions of species from microbes to man. That fact led the biologically uninformed science idiot, PZ Myers to attack me after he attacked John A. Davison for sharing similar views.

See: One crank dies, another rises to take his place


Behold James Vaughn Kohl.

Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction.

These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people here were taught to believe is the theory of evolution.

That theory is far too ridiculous to be anything but a joke in the context of biological-based increasing organismal complexity. But here, we have lots of jokers, don’t we? The proof of ecological variation that appears to refute the theory of evolution, which actually refutes itself, is that ecological adaptations occur too fast for mutations to compete with them as a source of anything but diseases and disorders.

See also:

Perhaps first, these researchers should consider how virus-driven RNA-mediated cell type differentiation occurs in species from microbes to man.

It is the viruses in the bacteria that drive the creation of new nutrient-dependent pheromone-controlled variants in bacteria. The new variants are ecologically adapted Biblical species of “like kind.” Anyone who claims that one species somehow evolved into another should start with an example and include experimental evidence of biologically based cause and effect. That should have been done ever since population geneticists invented neo-Darwinism.

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