epigenetic imprinting

Energy-dependent chirality

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See also: Achiral glycine Summary: Virus-driven energy theft alters the interactions between physics and chemistry that maintain biophysically constrained biodiversity. That’s how viruses are linked from mutations to all pathology. Nutrient energy-dependent changes in the context of the pheromone-controlled physiology of reproduction biophysically constrain biodiversity via the fixation of amino acid substitutions in supercoiled DNA, which … Energy-dependent chirality

Epigenetics and autophagy vs mutations and evolution (2)

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Plants send light to roots to ‘see’ underground My comment: Sending light requires an energy-dependent link from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects all organanized genomes from virus-driven energy theft and genomic entropy. See Schrodinger (1944) Excerpt: Indeed, in the case of higher animals we know the kind … Epigenetics and autophagy vs mutations and evolution (2)

From Precis to Proof in 6000 years (3)

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See first: Coulombic interactions facilitate polycombic adaptation See also: From Precis to Proof in 6000 years (2) See also: RNA catalyses nuclear pre-mRNA splicing 06 November 2013 Conclusion: …our data indicate that the spliceosome, like the ribosome44,45, uses RNA to effect catalysis in the context of a complex ribonucleoprotein assembly. Moreover, the common catalytic mechanism … From Precis to Proof in 6000 years (3)

Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)

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See: Light ‘drives’ adaptation; nothing ‘drives’ evolution See also: Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors Excerpt (from 1996):  Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that … Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)

Polycombic ecological adaptation as a science, not a theory (2)

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Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of … Polycombic ecological adaptation as a science, not a theory (2)

80 years of causal analysis (1936 – 2016)

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Roles of Mutation and Selection in Speciation: From Hugo de Vries [1902 definition of mutation] to the Modern Genomic Era Excerpt: …mutation is crucial in speciation because reproductive barriers cannot be generated without mutations. My comment: Chromosomal rearrangements link autophagy from energy-dependent changes in RNA-mediated amino acid substitutions and supercoiled DNA to all biodiversity via … 80 years of causal analysis (1936 – 2016)

Hecatombic evolution via oncocers and oncohistones

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Mutation-driven evolution is being replaced by a theory of hecatombic evolution that links oncocers and oncohistones to increasing organismal complexity via autophosphorylation and autophagy or something else as yet to be invented in the context of the new ridiculous theory. See for comparison: Polycomb enables primitive endoderm lineage priming in embryonic stem cells Abstract excerpt: … Hecatombic evolution via oncocers and oncohistones

How did the innate immune system evolve?

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Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites Abstract excerpt: Why would a system exist that reduces the vigor of potential mates prior to mating? Addressing this question could provide insights into mechanisms and evolution of sexual conflict and reveal sensory inputs that regulate aging. Highlights excerpt: An unknown signal accelerates larval … How did the innate immune system evolve?

Plant microRNAs slow virus-driven aging

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Six plant extracts delay yeast chronological aging through different signaling pathways The evolutionarily conserved nutrient-sensing signaling pathways that accelerate chronological aging in yeast (Figure 9) are known to stimulate chronological senescence and geroconversion of post-mitotic human cells; these pathways are likely to expedite organismal aging and cancer development in humans [87-93]. There is no experimental … Plant microRNAs slow virus-driven aging