stress-induced changes

Pseudoscientists hate what science explains! (3)

See also: Pseudoscientists hate what science explains (2) Summary: In addition to germline silencing via information transfer to the physical landscape of supercoiled DNA, multicopy transgene arrays are linked from changes in the microRNA/messenger RNA balance to variation in their somatic expression level. That fact helps to establish the difference between healthy longevity and pathology across generations. Problems with DNA replication can cause epigenetic changes that may be inherited for several generations My summary: The polycomb repressive complex 2, additional…

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RNA methylation, learning, memory and behavior,

Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice    Excerpt: Our findings suggest that m6A is regulated in an activity-dependent manner in the adult brain, and may function to fine-tune mRNA turnover during memory-related processes.   My comment: They cite: Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF (2015) N6-methyladenosine marks primary microRNAs for processing. Nature 519:482–485.   In the context of experience-dependent learning and memory, the authors link quantized energy…

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