Brains work via their genes just as much as their neurons Excerpt 1) Genes direct the production of the above-mentioned brain molecules via intermediaries made of RNA. RNA molecules tell the machinery of the cell when and how to make the proteins it needs to grow and function. Excerpt 2) This reciprocity between genes and … The Current State of Neuroscience
The convergent cancer evolution toward a single cellular destination Abstract excerpt: …cancer evolution is a directional process toward a defined cellular destination, a finding reconciling development and evolution, the two seemingly incompatible philosophies both adopted by the cancer research community, and also raising new questions to evolutionary biology. My comment: The idea that cancers evolve … Cancer: forward and reverse
Youyou Tu is the 12th women awarded the Nobel Prize in Physiology or Medicine (2015) for her discoveries concerning a novel therapy against Malaria. Historical perspective: Lasker~DeBakey Clinical Medical Research Award Excerpt: Tu discovered a passage in the Handbook of Prescriptions for Emergencies (340 CE) by Ge Hong that referenced Qinghao’s malaria-healing capacity. It said … Non-mainstream scientist shares Nobel prize in Medicine
Biophysically constrained nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation link the epigenetic landscape to the physical landscape of DNA in all living genera. Genomic stability arises in the context of a fine-tuned balance of viral microRNAs and nutrient-dependent microRNAs. RNA-mediated gene duplication and RNA-mediated amino acid substitutions stabilize organized genomes. Nutrient-dependent microRNAs are linked … Mechanisms of stress: from genes to cancer
See also: The creation and activation of GPCRs ‘Tree of life’ for 2.3 million species released This comment was removed from a “tree of life” discussion site by the “site staff.” In the context of anonymous “peer” review, the comment was removed for the following reason: PSEUDOSCIENCE, with an added threat that my account might … Viruses come alive: Tree of life pseudoscience
This startup thinks it can speed up a cure for cancer by bringing scientific research into the YouTube era Excerpt: The current scholarly publishing model did not allow me to present the research I was doing. I created [Figshare] initially out of purely selfish reasons and I spent my evenings and weekends creating a platform … Alternative pre-mRNA splicing and ecological adaptation
RNA viruses can hijack vertebrate microRNAs [miRNAs] to suppress innate immunity Excerpt: The extent of sequence complementary between the miRNA and mRNA leads to control of mRNA-encoded polypeptide levels by either a block in translation, degradation of the mRNA, or both5, 6. For RNA viruses, limited evidence exists for host miRNAs binding to viral RNAs … Pathology: Eating and breathing viruses
September 11, 2015 Case Western Reserve scientists discover long-sought genetic mechanism for cancer progression Excerpt: Action of a key lncRNA different in colon cancer versus normal colon tissue My comment: In yet another ridiculous misrepresentation of all that is currently known about how the epigenetic landscape is linked to the physical landscape of DNA in … Exosomes and the RNA-mediated future of medicine (3)
The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins Reported as: The exosome regulates the processing, degradation, and surveillance of a plethora of RNA species. Excerpt: …the exosome employs a general mechanism of recruitment to defined substrates and that this process is regulated through adaptor proteins. Journal article excerpt: (subscription required) The nuclear … Exosomes and the RNA-mediated future of medicine
See also: Viral and Cellular Genomes Activate Distinct DNA Damage Responses Excerpt: Central to life is the faithful replication, inheritance, and maintenance of genomic DNA. The MRE11/RAD50/NBS1 (MRN) complex andATMplay a critical role in this biological mandate (Ciccia and Elledge, 2010). Cellular double-strand breaks (DSBs) are sensed by MRN and trigger the assembly of DNA … Multi-omic analysis features (SNPs, miRNA)
