Non-mainstream scientist shares Nobel prize in Medicine
(click to enlarge)
Youyou Tu is the 12th women awarded the Nobel Prize in Physiology or Medicine (2015) for her discoveries concerning a novel therapy against Malaria.
Historical perspective: Lasker~DeBakey Clinical Medical Research Award
Excerpt:
Tu discovered a passage in the Handbook of Prescriptions for Emergencies (340 CE) by Ge Hong that referenced Qinghao’s malaria-healing capacity. It said “Take a handful of Qinghao, soak in two liters of water, strain the liquid, and drink.” She realized that the standard procedure of boiling and high-temperature extraction could destroy the active ingredient.
My comment: Recent learning about the thermodynamic stability of the active ingredient suggests that traditional Chinese medicine integrated what is now known about the biophysically constrained chemistry of protein folding during thermodynamic cycles of protein biosynthesis and degradation in bacteria and plants.
The cycles link ecological variation to ecological adaptations via nutrient-dependent RNA-mediated amino acid substitutions in all living genera. The thermodynamic stability of the plant extract was maintained for medicinal use.
Excerpt 2)
Tu pioneered a new approach to malaria treatment that has benefited hundreds of millions of people and promises to benefit many times more. By applying modern techniques and rigor to a heritage provided by 5000 years of Chinese traditional practitioners, she has delivered its riches into the 21st century.
My comment: Other researchers from China recently linked everything else known about RNA-mediated protein folding biochemistry via amino acid substitutions to the thermodynamic stability of all organized genomes. The “Holy Grail” of nutrient-dependent RNA-mediated protein folding is thermodynamically regulated.
See:
Structural basis of pre-mRNA splicingÂ
Structure of a yeast spliceosome at 3.6-angstrom resolution
Reported as: Chinese Scientists Discover Structural Basis of Pre-mRNA Splicing
On August 21st, the research team led by Prof. Yigong Shi from School of Life Sciences, Tsinghua University in China published two side-by-side research articles in Science, reporting the long-sought-after structure of a yeast spliceosome at 3.6 angstrom resolution determined by single particle cryo-electron microscopy (cryo-EM), and the molecular mechanism of pre-messenger RNA splicing. Until now, decades of genetic and biochemical experiments have identified almost all proteins in spliceosome and uncovered some functions. Yet, the structure remained a mystery for a long time. The works, primarily performed by Dr. Chuangye Yan, and Ph.D students Jing Hang and Ruixue Wan under Prof. Yigong Shi’s supervision, settled this Holy Grail question and established the structural basis for the related area. This work was supported by funds from the Ministry of Science and Technology and the National Natural Science Foundation of China.
See also: Feedback loops link odor and pheromone signaling with reproduction and Sensory feedback shapes individuality to provide equal space for behavioral excellence
Other mainstream scientists continue attempts to genetically engineer mosquitoes to limit their nutrient-dependent physiology of RNA-mediated ecological adaptation. These mainstream scientists ignore the contribution of RNA-mediated amino acid substitutions reported in Amino Acid Residues Contributing to Function of the Heteromeric Insect Olfactory Receptor Complex.
They use viruses to genetically engineer mosquitoes with mutations that limit reproduction. See: orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET and Genome-engineering with CRISPR-Cas9 in the mosquito Aedes aegypti.
If this diagram looks impressively complex compared to claims that linked traditional medicine across 5000 years of what should have been advances in treatment of diseases made by mainstream scientists, realize is that mainstream scientists get paid to do work that is represented like this.
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Will modern human populations adapt to the Zika virus?
5 MIN READ
0
The unoffically uninvited
3 MIN READ
0
MicroRNA-mediated RNA epigenetics
2 MIN READ
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
MicroRNAs vs Red Queen hypothesis
4 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Cyclic cosmology and the stability of organized genomes
4 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
Unraveling the secrets of RNA-mediated events
2 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
The creation and activation of GPCRs
4 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
Information and communication (2)
6 MIN READ
0
Information and communication
2 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Thermodynamic constraints did not evolve
3 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed
2 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
Virus-driven death by evolutionary theory
3 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Is SUMOylation RNA-directed DNA methylation?
2 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
RNA-mediated development (2)
< 1 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
DNA organization, structure, and function
7 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Correctly modeling life on this planet
3 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
Are mutations beneficial?
4 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
0
Pharmacogenomics
3 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
No understanding of biodiversity
2 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
New technique used in report of atomic-level ecological adaptations
3 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Cell-type differentiation
2 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Alternative splicings (very technical)
2 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Constraints on mutational drift
< 1 MIN READ
0
A mathematical model of phenotypic cause, effects on genes, and affects on behavior
2 MIN READ
0
Non-random adaptive evolution: fast forward to March 2013
< 1 MIN READ
0
The genetics myth meets the great pheromone myth
2 MIN READ
0
Human Pheromones: Epigenetic Effects on Hormones and Their Affects on Behavior
3 MIN READ
0
The neuroscience of sexual attractions
2 MIN READ
0
The Ghost in Your Genes – BBC Horizon
< 1 MIN READ
0
Bio-CHEMICAL complexity
< 1 MIN READ
0
What to do with research results: Warning!
2 MIN READ
0
Human pheromones and the visual appeal of other people (Part Three)
2 MIN READ
0
Creation vs Evolution? Pre-existing genetic variation, not random mutation
2 MIN READ
0
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