The tipping point (revisited): 74,000 publications

By: James V. Kohl | Published on: June 12, 2018

President Trump and Kim Jong Un will probably discuss this fact: All serious scientists have learned that quantized energy-dependent microRNA biogenesis links everything known about the creation of sunlight from the physiology of food energy-dependent pheromone-controlled reproduction to viral latency and healthy longevity in the context of the creation of the innate immune system of bacteria.
See also: The tipping point (revisited): 73,000 publications May 16, 2018
In less than one month, nearly 1000 publications have been added to the total that can be found via this search for microRNA
The creation of the innate immune system of bacteria links the Major Histocompatibility Complex to all biophysically constrained biodiversity via what is known about how the creation of subatomic particles must be linked to questions posed by Schrödinger in “What is Life? (1944).
See for comparison: Major Histocompatibility Complex I- Structure, Mechanism and Functions
Excerpt 1)

The peptide-binding groove present in the central region of the α1/α2 heterodimer helds the peptide being presented.

Excerpt 2)

This helps mediate cellular immunity which is the primary means to address intracellular pathogens, such as viruses and some bacteria.

See for comparison: Energy as information and constrained endogenous RNA interference Feb 15, 2017
See also: What is life when it is not protected from virus driven entropy Mar 30, 2016
See also: microRNA + MHC
For example: Novel and Haplotype Specific MicroRNAs Encoded by the Major Histocompatibility Complex March 1, 2018

Several of the identified mature miRNA and pre-miRNA transcripts are unique to specific MHC haplotypes and overlap common SNPs. Furthermore, 43 of the 89 identified novel miRNA transcripts lie within linkage disequilibrium blocks that contain a disease-associated SNP. These disease associated SNPs are associated with 65 unique disease phenotypes, suggesting that these transcripts may play a role in the etiology of numerous diseases associated with the MHC. Additional in silico analysis reveals the potential for thousands of putative pre-miRNA encoding loci within the MHC that may be expressed by different cell types and at different developmental stages.

See for comparison: Human MHC architecture and evolution: implications for disease association studies April 8, 2008.

Recent cataloguing and analysis of variation over the complete MHC has facilitated localization of susceptibility loci for autoimmune diseases, and provided insight into the MHC‘s evolution. This review considers how the unusual genetic characteristics of the MHC impact on strategies to identify variants causing, or contributing to, disease phenotypes. It also considers the MHC in relation to novel mechanisms influencing gene function and regulation, such as epistasis, epigenetics and microRNAs.

There may be one or two serious scientists who still claim the the MHC evolved, but there is no experimental evidence of biologically based cause and effect that supports such ridiculous claims. For a historical perspective, see:
From Fertilization to Adult Sexual Behavior (1996)

…in what cells and by what processes does MHC recognition occur? Similarly, what are the cells and processes by which chromosome recognition occurs? Are such perceptions interpreted primarily in the brain? Or do those perceptions and recognitions occur primarily as intranasal molecular events which are then transmitted to the brain? Are MHC-related perceptions and recognitions mediated by olfactory or vomeronasal (VNO) tissues or is there additional participation by immunological tissues—tissues (i) long known to exist within the nasal cavity, and (ii) highly specialized for MHC-based interacting with molecules arriving from exogenous sources (Korsrud and Brandtzaeg, 1983)? This topic will reappear below. In any case, these several immunological findings and the presence of MHC-encoded, sexually dimorphic immunological tissues in both the nasal cavity and epidermis have prompted at least one researcher to formulate an immunological hypothesis….

All these questions have since been answered and yet there are many biologically uniformed theorists who refuse to accept the facts. The facts have been placed into the context of what is known about how the anti-entropic virucidal energy of sunlight links photosynthesis from quantum physics to classical physics via what is known about the creation of the MHC and viral latency.
See for comparison: A Gain-of-Function Mutation in EPO in Familial Erythrocytosis

This mutation, a single-nucleotide deletion (c.32delG), introduces a frameshift in exon 2 that interrupts translation of the main EPO messenger RNA (mRNA) transcript but initiates excess production of erythropoietin from what is normally a noncoding EPO mRNA transcribed from an alternative promoter…

Reported as: Family blood mystery solved

“It’s paradoxical that a mutation, in this case the loss of a base, leads to increased production,” says Wage.

The virus driven theft of quantized energy links the loss of the base to the pathology in the context of more than 1700 nutrient-dependent pheromone-controlled hemoglobin variants that exemplify ecological adaptations.
See: HbVar: A Database of Human Hemoglobin Variants and Thalassemias
and remember:

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla. — Dobzhansky (1973)

See also: Humans And Chimps Differ At Level Of Gene Splicing (2007)
And:  RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

Here, we systematically tested the hypothesis that endogenous variation in snRNA levels confers regulatory capacity on these RNAs. We discovered that the relative abundance of different snRNAs varies by an order of magnitude during development, across tissues, and between healthy and malignant cells. Mimicking this physiological variability by ectopically perturbing snRNA expression levels drove gene-specific changes in alternative splicing, but not widespread splicing failure. Genes that were particularly sensitive to snRNA level perturbation in cultured breast epithelial cells were preferentially mis-spliced within a breast cancer cohort. Our results demonstrate that unexpected variability in snRNA levels contributes to the establishment of global splicing programs in both healthy and diseased cells.

In the next few months, the total number of published works that link quantized energy-dependent microRNA biogenesis to all biophysically constrained biodiversity on Earth will climb to more than 75,000. To place that into perspective see: Schrödinger at 75 – The Future of Biology – September 2018
More than 1000 publications for each year since Schrödinger presented “What is Life?” will attest to the displays of human idiocy by those who did not link food energy from the pheromone-controlled physiology of reproduction to all biodiversity in the context of Darwin’s “conditions of life.”
Denuclearization of North Korea will attest to the fact that the virus-driven degradation of messenger RNA in specific human populations is a bigger threat than nuclear war will ever be.

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