Energy-dependent alternative splicings 1996 – 2016 (2)

By: James V. Kohl | Published on: December 31, 2016

See also: Energy-dependent alternative splicings 1996 – 2016

Re: Rs3827760 is Val370Ala and EDARV370A

No matter what it is called, Val370Ala may be the best example of how nutrient energy-dependent biophysically constrained pheromone-controlled viral latency protects all organisms from virus-driven energy theft and all pathology.
For example, see: Genome recoding by tRNA modifications

The succession of mRNA codons controls the synthesis of polypeptides through the complementarity between each of the 64 possible codon triplets and the tRNA anticodons that decode the 20 amino acids of the cellular proteome. Central to the mRNA decoding process is the backward compatibility of the codon : anticodon recognition that is mediated by tRNA.

See also: In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory


•    Epigenetic regulation represents a key mechanism of learning, memory and cognition.
•    Chromatin topology is emerging as a major regulator of neuronal gene expression.
•    Dynamic chromatin topology changes correlate with activity-dependent transcription.
•    DNA double-strand breaks facilitate induction of immediate early gene transcription.

All their highlights can be placed into the context of this article from 2005.
Feedback loops link odor and pheromone signaling with reproduction
The feedback loops determine whether of not a species survives via links from energy-dependent autophagy to learning, memory, RNA-mediated amino acid substitutions and supercoiled DNA.
BDNF Val66Met and COMT Val158Met are also examples that link energy-dependent changes in base pairs from single nucleotide polymorphisms to life history transitions in morphological and behavioral phenotypes.

See also: Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision

Our findings revealed a differential impact of BMP signaling on appendage fate specification that has ancient roots and occurs repeatedly throughout vertebrate evolution.

This was reported by Bob Yirka as: Researchers identify signals during embryonic development that control the fate of skin cells to be sweaty or hairy

The fate of all cell types is energy-dependent and RNA-mediated via natural selection for codon optimality. See for example:
rs3827760, also known as 1540T/C, 370A or Val370Ala, is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2. This SNP links the mouse model of cell type differentiation to humans. That fact has been known for at least 3 years.

  1. Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant
  2. A genetic basis of variation in eccrine sweat gland and hair follicle density
  3. A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Other energy-dependent base pair changes link natural selection for codon optimaility from SNPs to RNA-mediated amino acid substitutions and differences in intelligence and/or unexplained death risk.
A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence
An insertion/deletion polymorphism within 3’UTR of RYR2 modulates sudden unexplained death risk in Chinese populations
Few people can place the findings on energy-dependent codon optimaility into the proper context of natural information processing. How many do you know who might claim that natural selection links mutations to evolution?

Compare the people who think in terms of mutation-driven evolution to those who know the energy-dependent differences between archaea and bacteria. The greater energy-dependent stability of organized genomes in bacteria can be liked to the stability of eukaryotes. The instability of archaea genomes can be linked from virus-driven energy theft to the degradation of messenger RNA and negative supercoiling of DNA.
All cell type stability link the sun’s anti-entropic virucidal energy from the creation of all biodiversity to supercoiled DNA, which protects all organized genomes from virus-driven energy theft and genomic entropy, which links mutations to all pathology.
See for instance, (2013) MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination

The authors

…address long-standing fundamental questions linked to compelling clinical needs—how to distinguish between the aberrant dynamics of epithelial–hybrid–mesenchymal transitions during tumorigenesis vs. the normal programs of embryonic development and tissue regeneration.

The “normal programs” are energy-dependent and biophysically constrained by the physiology of reproduction.The senior author should have received the 2016 Nobel Prize for linking energy-dependent autophagy to supercoiled DNA, but the Prize is not awarded posthumously, as I recall.

Politicized “science” often prevents the Prize in Physiology or Medicine from being awarded to anyone whose works challenge the ridiculous theories about mutation-driven evolution. Those who present experimental evidence of how cell type differentiation is biophysically constrained by energy-dependent changes in the microRNA/messenger RNA balance tend to be virtually ignored.

Even some of the creationists I have encountered want others to keep thinking in terms of evolution rather that energy as information. Peter Berean, for example, decided to invent the term “bio-functional information” when he realized that the sun’s anti-entropic virucidal energy was the only obvious link from microRNA flanking sequences to all healthy longevity and that virus-driven energy theft was the link to all pathology.If you want to learn how serious scientists are combating evolution to fight disease on two fronts, see any claim made by an old earth creationist, or any claim made by any atheist. The similarities led Peter Berean to substitute “bio-functional information” for de Vries 1902 definition of “mutation.”

See for comparison:

2003 Bacterial self–organization: co–enhancement of complexification and adaptability in a dynamic environment

2006 Seeking the foundations of cognition in bacteria: From Schrödinger’s negative entropy to latent information

2009 Learning from Bacteria about Natural Information Processing

See also: CRISPR study reveals unexpected roles of non-coding RNAs

Royal Society’s Sir Venki Ramakrishnan Agrees to Post Public Evo Audio

…the public discussion from the recent “new trends” in evolution conference will be posted shortly online on the Royal Society event webpage.

Suzan Mazur helped force them to do what they claim they would do:

Recorded audio of the presentations are available below.

It’s been six weeks and the recorded audios from the audience are not available.

If the recorded comments become available, the public discussion may help to reveal that the fate of all cell types is energy-dependent and RNA mediated via natural selection for codon optimality and autophagy.

See for other examples: Nutrient-dependent/pheromone-controlled adaptive evolution: a model

These two reports (Grossman et al., 2013; Kamberov et al., 2013) tell a new short story of adaptive evolution. The story begins with what was probably a nutrient-dependent variant allele that arose in central China approximately 30,000 years ago. The effect of the allele is adaptive and it is manifested in the context of an effect on sweat, skin, hair, and teeth. In other mammals, like the mouse, the effect on sweat, skin, hair, and teeth is due to an epigenetic effect of nutrients on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones control the nutrient-dependent hormone-dependent organization and activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates as previously indicated. That means the adaptive evolution of the human population, which is detailed in these two reports, is also likely to be nutrient-dependent and pheromone-controlled, since there is no other model for that.

Each week’s science news brings additional representations of facts that refute all neo-Darwinian pseudoscientific nonsense by linking Darwin’s “conditions of life” to all biodiversity. Most science news outlets still report and/or tout pseudoscientific nonsense because the reporters missed the fact that life is nutrient-dependent and the physiology of reproduction is controlled by pheromones is species from microbes to humans.
Can you imagine how embarrassed you would be if you had not learned that all organisms must eat or they cannot reproduce, which means they could never have become an organism of a species? What’s worst is that no experimental evidence of biologically-based cause and effect support claims that one species evolved into another. For comparison, this recent report shows changes in organized genomes that link the nutrient-dependent pheromone-controlled physiology of reproduction in moths to bacteria and from bactreria to humans via conserved molecular mechanisms of RNA-mediated protein folding chemisrty.

Engineers create programmable silk-based materials with embedded, pre-designed functions

… the researchers created a surgical pin that changes color as it nears its mechanical limits and is about to fail, functional screws that can be heated on demand in response to infrared light, and a biocompatible component that enables the sustained release of bioactive agents, such as enzymes.

The news article cites: Directed self-assembly of silk fibroin into bulk materials: with the subtitle: Programming function into mechanical forms from the nano- to macroscale,
I look forward to learning why they are claiming that energy-dependent assembly is “directed self-assembly.”

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