Epigenetic effects of viruses on cellular homeostasis (2)

By: James V. Kohl | Published on: February 4, 2015

TSLive: The Enemy Within (video)

How viruses wield tiny molecules of RNA to help them persist in our bodies for years, decades, and sometimes an entire life span

By The Scientist Staff | February 1, 2015

This brief video (below) packages an exceptional amount of information. In less than 2 minutes, it links the epigenetic effects of viral microRNAs to the differentiation of all cell types in all individuals of all species via the innate ability of immune system regulation to control their proliferation.
Thermodynamic cycles of protein biosynthesis and degradation link changes in the microRNA/messenger RNA balance to protein biosynthesis and degradation. The chemistry of protein biosynthesis is nutrient-dependent, and RNA-mediated amino acid substitutions stabilize the DNA in organized genomes.
Stability of DNA is perturbed by nutrient-stress and social stress. Stress also may cause loss of function mutations that link perturbed protein folding to physiopathology.
Virus-induced changes in the microRNA/messenger RNA balance may be beneficial if they enable nutrient-dependent pheromone-controlled fixation of amino acid substitutions. However, theorists typically confuse what happens in healthy organisms with what happens in cases where viruses cause physiopathology.
Short-term physiopathology is obvious within the context of rhinoviruses and other viruses that cause treatable symptoms. Long-term changes in the microRNA/messenger RNA balance lead to diseases and disorders when the immune system is stressed by the lack of essential nutrients or lack of social contact or changes during aging that alter the ability of the innate immune system to respond with maximal efficiency.
The fine-tuning of the microRNA/messenger RNA balance is required for health and reproductive fitness and it is essential to the development of morphological and behavioral phenotypes in species from microbes to man. See also: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems.

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Epigenetic effects of viruses on cellular homeostasis

Additional content is posted here and can be found via a search for “viral microRNA

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