A thought experiment
(click to enlarge)
I may be confused about proximate and ultimate cause, especially if the role of transgenerational epigenetic inheritance is not central to the extended evolutionary synthesis. Isn’t transgenerational epigenetic inheritance the problem that led Dickins and Rahman to suggest a thought experiment; one where epigenetic mechanisms introduce shifts in learning bias for certain associations as would endocrine functioning? If so, my model (Kohl, 2012), which combines the epigenetic effects of nutrient chemicals and pheromones with biased endocrine functioning and adaptive evolution, may help move the modern synthesis forward.
I tried this before, but the evolutionary continuum from microbes to man (Kohl, 2007) seems too much to grasp in the context of biased endocrine functioning. However, the honeybee has since emerged as a model organism to exemplify nutrient chemical and pheromone-dependent epigenetic alterations in endocrine functioning. These epigenetic effects that bias endocrine functioning are required for the adaptive evolution of reproduction.
Reproduction is required for transgenerational epigenetic inheritance and species diversity, which is perhaps better represented in the threespine stickleback vertebrate model organism. However, in all invertebrate and vertebrate model organisms, nutrient chemicals establish the ecological niche of individuals, and the presence of conspecifics establishes their social niche (as also occurs with microbial species).
The honeybee best exemplifies how ecological and social niches contribute to the hypothalamic gonadotropin releasing hormone (GnRH) neurogenic niche that is responsible for the adaptive evolution of the human brain. Simply put, what the queen eats determines her pheromone production and everything else about the social interactions in the colony, including the required epigenetic effects of pheromones on the neuroanatomy of the worker bee’s brains during the development of their diverse behaviors that change with exposure to different chemical input associated with a variety of other sensory input of lesser importance / salience.
Of course, that sounds too simple in the context of the extended evolutionary synthesis and human brain evolution. But the molecular biology is conserved across species, which is helpful for proof of concept. In placental mammals, for example, in utero nutrient chemical transfer is responsible for organization of the brain’s postnatal activation by nutrient chemicals and pheromones. The proper GnRH-driven behavioral response of the infant to activation by these chemicals ensures its survival, just as the proper response of the honeybee worker bee’s brain to nutrient chemicals and pheromones ensures its survival and helps to ensure the colony’s survival via changes in the neuroanatomy of its brain. (Parenthetically, spectral input may or may not be correlated with direct epigenetic effects on the brain, but it is not causal to brain development.)
Model organisms have their RNA-mediated molecular biology in common with all other organisms. No organism survives in the absence of sufficient nutrient chemicals. Ecological niches contract. And no species survives in the absence of reproduction controlled by pheromones. I think that’s why we are now seeing more reports on transgenerational epigenetic inheritance, with causal links to speciation via ecological and social niches in all species. We should soon see the addition of neurogenic niches in many others.
What I don’t see is anyone who is integrating the ecological, social, and neurogenic niches and considering the epigenetic effects of nutrient chemicals and pheromones in the context of endocrine disruption and transgenerational epigenetic inheritance. Nutrient chemicals and pheromones promote homeostasis and also allow adaptive evolution, including adaptive evolution of the human brain. Endocrine disruption causes atypical development of the brain and the body.
Isn’t that the apparent design we might all someday see in biology? Isn’t seeing the apparent design required to move forward from the Modern Synthesis to the Extended Evolutionary Synthesis?
Jim Kohl
www.pheromones.com
On 5/27/2012 3:26 AM, R.J.King@lse.ac.uk wrote:
jvkohl:
I fear that you may have confused proximate and ultimate. Easily done. Epigenetics, while fascinating, has no impact on the central doctine of genes as the sole information carriers. Epigenetics are just one more set of mechanisms by which genes achieve their ultimate aim of replication. I.e. they are part of the suite of adaptations. The University of Utah has an excellent site detailing this
https://learn.genetics.utah.edu/
May I particularly recommened this page which beautifully illustrates the way in which behaviours and epigenetics intereact in this way to calibrate personality to environment?
https://learn.genetics.utah.edu/content/epigenetics/rats/
My suspicion is that the folk biology concept of "biology=fixed at birth" dies very very hard and keeps recurring in odd forms in even the best and brightest of us.
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A million dollar paradox?
2 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (5)
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
Teaching the biologically uninformed
3 MIN READ
0
Innovative Neurotechnologies Link Sunlight to Precision Medicine
4 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Plasma created by sunlight and RNA–mediated epigenetic heredity
2 MIN READ
0
Positive feedback loops and epigenetic traps
2 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
Let there be anti-entropic light (3)
6 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Cell type differentiation: atoms to ecosystems
2 MIN READ
0
Too complex for the Complex Biological Systems Alliance
4 MIN READ
0
Rediscovering quantum behavior
2 MIN READ
0
From dust to genomic entropy?
3 MIN READ
0
Virus, transposon and plasmid evolution
< 1 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Models are not theories (1)
2 MIN READ
0
MicroRNA-encoded behavior
7 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Can veterans and other prisoners escape pseudoscience?
2 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
RNA central and RNA-mediated.com
6 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
Controled Stem Cell Expansion
3 MIN READ
0
Neo-Darwinian logic is nonsense
3 MIN READ
0
FREE* SAMPLE: Histone modification
4 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (3)
2 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs model
2 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
The Current State of Neuroscience
3 MIN READ
0
Cancer: forward and reverse
2 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Bird watchers and RNAs in cancers
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Microbes to humans 2015 Nobel Prize
2 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
A 5-10K comparison of design principles to evolution
3 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Nucleic acids: Stability of DNA/RNA
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (3)
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (2)
< 1 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Multi-omic analysis features (SNPs, miRNA)
3 MIN READ
0
Anti-entropic effects on the origin of life
< 1 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
From fertilization to RNA-mediated events and back
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
Metabolic competition and cancer
2 MIN READ
0
Natural selection: an anti-entropic force?
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Creating genes and species
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
A “new” code enables ecological adaptation
4 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
RNA-mediated X chromosome inactivation
3 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Atomic-resolution of cell type signaling
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Unraveling evolutionary pseudoscience
2 MIN READ
0
Eibi Nevo gets it wrong
3 MIN READ
0
Rs3827760 is Val370Ala and EDARV370A
3 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
The stability of organized genomes (2)
5 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
Is the best Chinese research from China?
3 MIN READ
0
The stability of organized genomes
5 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Big Bang Cosmology vs Reality
< 1 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Hematopoiesis and practopoiesis
4 MIN READ
0
RNA-mediated morphological AND behavioral phenotypes
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Decreased phenotypic variation: Faith in Facts
7 MIN READ
1
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Unconscious affect (revisited)
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
Olfactory perception of genetic information
2 MIN READ
2
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
RNA-mediated events from A to Z
2 MIN READ
0
“First” evidence
5 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
RNA-mediated development
2 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
MicroRNAs and inappropriate functions
2 MIN READ
0
Rejecting pseudoscientific nonsense
6 MIN READ
1
Living the life that randomness created? (Sarcasm alert)
3 MIN READ
0
30 years of theoretical nonsense
3 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Tweaking the story to fit the theory
5 MIN READ
0
Appetite for ingesting theories (raw)
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Bee-birthed epigenetics and primate cell types
5 MIN READ
0
A lighting requirement for life
11 MIN READ
3
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Bees and primates automagically evolve
3 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Five years of Ferguson
2 MIN READ
0
Computing via phosphorylation and fixation
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
Viruses in gut microbes
4 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
Finding odor and taste receptors everywhere
6 MIN READ
0
Linking the origin of birds to dinosaurs
< 1 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Tet3 regulation of nutrient-dependent cell type differentiation
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Viruses, proteins, and gut metagenomes do not evolve
< 1 MIN READ
0
Pathology constrains X-linked evolution
2 MIN READ
0
Re-inventing a completely new thing
4 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes (2)
10 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
MicroRNAs and invasive phenotypes
< 1 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Deeply ingrained thoughts
< 1 MIN READ
0
Graphic misrepresentations of ecological adaptation
2 MIN READ
0
Too many targets for theories
3 MIN READ
0
Methylation maintains cell type differences (2)
2 MIN READ
0
Methylation maintains cell type differences
3 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic effects of soil bacteria on plants
< 1 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling life on this planet
3 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Behavior (4): All responses are RNA-mediated in birds
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Virus-driven origin of life
2 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
Walk towards the light
< 1 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
Assembling yourself: Molecular self / other recognition
4 MIN READ
0
What about birds?
5 MIN READ
0
Virus-driven cell type differentiation
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3 MIN READ
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
Atheism: Arrogant, useless, and divisive ignorance
7 MIN READ
0
The anti-entropic force of "Nature"
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
Military combat training to fight disease
3 MIN READ
0
Theoretical physics and molecular biology
5 MIN READ
0
Atoms to ecosystems is not almost a molecular ecology
3 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis (2)
2 MIN READ
0
RNA-mediated epigenetic modification via DNA-methylation
4 MIN READ
0
Quantum physics, quantum biology, and quantum consciousness
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Biological energy and a microbiome model of a light-driven time machine
3 MIN READ
0
The biologically-based origin of the mammalian placenta (2)
6 MIN READ
0
Quantum Superpositions: let there be light
4 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Sneaking up from behind (2)
3 MIN READ
0
Sneaking up from behind
4 MIN READ
0
Quantum entanglement, mass, and biomass
4 MIN READ
0
Physicists: Desperate Acts
16 MIN READ
0
An epigenetic trap (the sequel)
10 MIN READ
0
Mute points: most are afraid to mention them
6 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
All of "like kind" in the (bigger) family
6 MIN READ
1
Environment epigenetically shapes the immune system
3 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
Unconstrained evolutionary innovability
4 MIN READ
0
RNA-protein interactions reveal biophysical to ecological landscapes
2 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
ISHE's human ethology group
2 MIN READ
0
Amino acid homeostasis for a Happy New Year!
6 MIN READ
0
Understanding cell type differentiation
3 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
Removing natural selection; reshaping the horse; adjusting evolutionary theory
4 MIN READ
0
Communication, not mutations
2 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
The future of physics predicts no future for evolutionary theory
3 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Atoms to ecosystems: Evolutionary theory vs the coelacanth
6 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
One test of bioenergetic health?
2 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Eliminating correlations from evolutionary ecology
6 MIN READ
0
RNA-mediated species specificity
2 MIN READ
0
Are mutations beneficial?
4 MIN READ
0
The key to science: experimental evidence
5 MIN READ
0
Ecological adaptations reported as evolution in insects and mammals
4 MIN READ
0
There’s a model for that!
5 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
SNPs and millions of small variations in the human genome
3 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Achiral GnRH: no prophesy, just prediction
9 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
Making sense of quotes scattered across disciplines
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
De novo DNA methylation?
3 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
0
We need pattern recognition, not proclamations
3 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Pharmacogenomics
3 MIN READ
0
Sexual differentiation of cell types in plants
2 MIN READ
0
A model of MHC 'evolution'
2 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
ALPHA GENOMIX
7 MIN READ
2
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
Evolutionary theorists and evolutionary theists live under rocks
< 1 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
Understanding physical forces of ecological variation and adaptation
< 1 MIN READ
0
Eliminating evolutionary theory
3 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
2014 and 2004 Nobel Prize in Medicine
3 MIN READ
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2 MIN READ
2
How much good can be attributed to social science theories?
< 1 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
RNA-mediated genetic engineering (Part 2)
3 MIN READ
0
RNA-mediated genetic engineering
2 MIN READ
0
RNA-mediated events are not a matter of faith
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Unassailable evidence vs assumptions
4 MIN READ
0
Forces of "Nature" limit dissemination of information
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Systems biology and memory disorders
3 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
Did our adapted mind evolve? (Revisited)
2 MIN READ
0
De novo gene Creation sans evolution of genes via mutations
4 MIN READ
0
Did our adapted mind evolve?
6 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Miracles are not miracles to evolutionary theorists
2 MIN READ
0
Mathematical model: microRNA and epigenetic regulation
2 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
“Kardashians” in science
< 1 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
New technique used in report of atomic-level ecological adaptations
3 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
Memory of repression and memory of behavior
2 MIN READ
0
Quantum physics meets Evolutionary Psychology News
2 MIN READ
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1 MIN READ
0
Watching and waiting for more retractions
2 MIN READ
0
RNA-mediated ecological adaptations of teeth
4 MIN READ
0
A molecular visualizer of worthwhile molecular biology
2 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
RNA-mediated events found everywhere
2 MIN READ
0
Reseachers think copy number variation is genetically determined
< 1 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
Behavior (3): All responses are RNA-mediated in bees
3 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
Behavior: The first response is RNA-mediated not genetically-determined
3 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Pattern recognition and conserved receptors (TAARs)
5 MIN READ
0
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Baby talk: More misrepresentations of ecological adaptations
2 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs differentiate neuronal cell types
3 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Drunks and Monkeys: Pseudoscientific nonsense
2 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Behavior is receptor-mediated
10 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Soft atheism: a case for Creation
< 1 MIN READ
0
Nutrition, pheromones and cancer (2)
2 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Not focused and self-aggrandizing
2 MIN READ
0
Nutrient-dependent cooperation vs cannibalism (video)
2 MIN READ
0
Another powerful refutation of mutation-initiated natural selection
4 MIN READ
0
The new light of chromosomal rearrangements
3 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
Chromosomal rearrangements and ecological adaptations
4 MIN READ
0
The wrong picture of our evolution
4 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Jay R. Feierman
3 MIN READ
0
Don't tell the Creationists
2 MIN READ
0
Targeting a cancer gene
2 MIN READ
0
Alternative splicings (very technical)
2 MIN READ
0
Pulses of olfactory/pheromonal input
2 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Seeds of life: astrobiological theory and mutations theory
3 MIN READ
0
Your comment is awaiting moderation
2 MIN READ
0
Nutrient-dependent pheromone-controlled stickleback evolution
2 MIN READ
0
Functional coding variants are not mutations
2 MIN READ
0
Mirror neurons and microRNA: theory vs biological facts
4 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Are pheromones responsible for human body odour assessment?
2 MIN READ
0
Nutrient-dependent / pheromone-controlled social structure
2 MIN READ
0
Random mutations: nothing adaptive in 3 billion years
< 1 MIN READ
0
A flawed model: no tripartate synapse in the adult brain
3 MIN READ
0
Evolved development of olfactory systems
2 MIN READ
0
A “new” view of evolution sans mutations
< 1 MIN READ
0
Epistasis as the primary factor in molecular evolution
4 MIN READ
0
Epigenetics and metabolism converge with pheromone production
2 MIN READ
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Behavioral epigenetics in ecological context
2 MIN READ
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Epigenetic maintenance of transcription / neuronal migration
2 MIN READ
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Epigenetics and evolutionary success
< 1 MIN READ
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Non-random evolution of a “molecular handshake”
2 MIN READ
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Adaptive evolution: Genetic selection against some disorders
3 MIN READ
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Epigenetic effects underlie sexual preferences IV
< 1 MIN READ
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Music to our ears and song in birds: a common sense approach
2 MIN READ
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Thinking about what we know (or not)
2 MIN READ
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A mathematical model of phenotypic cause, effects on genes, and affects on behavior
2 MIN READ
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A newly discovered hypothalamic neurogenic niche in the brain
< 1 MIN READ
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Epigenetic effects underlie sexual preferences II
3 MIN READ
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Fish Odor Syndrome
< 1 MIN READ
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One of the clearest examples of epigenetic effects
< 1 MIN READ
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Epigenetic effects underlie sexual preferences (duh, and food preferences)
2 MIN READ
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Epigenetic effects on chromatin and regulatation of gene expression (in Archaea?)
2 MIN READ
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The genetics myth meets the great pheromone myth
2 MIN READ
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Modeling epigenome dynamics: Polycomb
2 MIN READ
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MicroRNA binds messenger RNA: Adaptive Evolution
< 1 MIN READ
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A key mutational event? More story-telling. Olfaction modulates vision.
4 MIN READ
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A key mutational event? That’s not very likely.
3 MIN READ
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Mutated genes and accidental intelligence?
< 1 MIN READ
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Fatal attractions: a fear of pheromones
2 MIN READ
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Genetic Influences on Epigenetically Effected Disease
2 MIN READ
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Disorders of development: altered microRNA / messenger RNA balance
< 1 MIN READ
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Eat like a monkey; act like a monkey
2 MIN READ
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Do molecular mechanisms vary across species?
2 MIN READ
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Human Pheromones: Epigenetic Effects on Hormones and Their Affects on Behavior
3 MIN READ
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Creation vs Evolution: Expression of a newly found gene
2 MIN READ
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Evolution at work sans random mutations (Part 2)
< 1 MIN READ
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Epistasis: Epigenetic effects of nutrient chemicals and their metabolism to pheromones
< 1 MIN READ
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Sex differences in Alzheimer's and everything else
2 MIN READ
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Sex differences in Alzheimer’s and everything else
2 MIN READ
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The Knowing Nose: Chemical Signals Communicate Human Emotions
< 1 MIN READ
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The logic of gene regulatory networks
3 MIN READ
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Human Pheromones: Epigenetic Effects of Odors and Their Affects on Behavior
2 MIN READ
0
Creating new genes (and controlling diversity)
2 MIN READ
0
The end of random mutations theory
2 MIN READ
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Epigenetic effects of viruses on cellular homeostasis
< 1 MIN READ
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Diet epigenetically effects development of the primate brain
< 1 MIN READ
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Human pheromones determine our social behavior (REJECTED)
3 MIN READ
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Human pheromones: epigenetic effects
< 1 MIN READ
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Pheromonemotionally speaking
2 MIN READ
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Human pheromones: another attempt to change the concept
3 MIN READ
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Nobel laureate challenges psychologists to clean up their act
2 MIN READ
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Human pheromones and the fusiform fooled you area for face recognition
3 MIN READ
0
The Missing Transgenerational Epigenetic Links
2 MIN READ
0
Playing with breasts (e.g, with a new THEORY of why only heterosexual men love them)
3 MIN READ
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Society for Social Neuroscience Presentation scheduled 10/11/12
2 MIN READ
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Epigenetic effects on stochastic gene expression and evolutionary psychology
2 MIN READ
0
The Ghost in Your Genes – BBC Horizon
< 1 MIN READ
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Epigenetic effects of docosahexaenoic acid (DHA) on the primate brain
2 MIN READ
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Embracing galaxy-wide, cellular, and brain complexity
2 MIN READ
0
“Just-So” stories vs scientific explanations
2 MIN READ
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Insect to human cognition
2 MIN READ
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More complicated than 1-2-3
2 MIN READ
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Docosahexaenoic acid vs. creative use of mutations in natural selection
3 MIN READ
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What to do with research results: Warning!
2 MIN READ
0
Mischaracterizations of adaptive evolution by psychologists and biologists
2 MIN READ
0
Human pheromones and the epigenetic effects of isolation
2 MIN READ
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Transgenerational epigenetic inheritance of sexual orientation
2 MIN READ
0
Natural selection and the behavior of whole organisms
< 1 MIN READ
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Natural selection: New insights are unlikely
< 1 MIN READ
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Natural Selection and the Complexity of the Genome
2 MIN READ
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Human pheromones: an epigenetic continuum from microbes to mammals
3 MIN READ
0
Biological facts constrain proponents of random mutations theory
2 MIN READ
0
Pheromones, Reciprocity, and Prosocial Behavior
3 MIN READ
0
Is the language of God the god problem? (1530 words)
6 MIN READ
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Envisioning, hindsight bias, plagiarism, or cheating
3 MIN READ
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The Epigenetics of Drug Development and Cholesterol Levels
< 1 MIN READ
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Woefully ignorant politicians and popular science
2 MIN READ
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Pheromones and multicellularity
< 1 MIN READ
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Human pheromones and autism spectrum disorders (2)
2 MIN READ
0
Epigenetic alterations due to stress
< 1 MIN READ
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Epigenetic effects on the evolution of behavior
2 MIN READ
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CB Nemeroff: Off Restriction
< 1 MIN READ
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Human pheromones and autism spectrum disorders
2 MIN READ
0
Human pheromones, the social brain and simple math computations
2 MIN READ
0
Children’s healthy diets lead to healthier IQ
< 1 MIN READ
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Transgenerational epigenetic inheritance via nutrient chemicals
1 MIN READ
0
Human pheromones and IQ via neurogenic and socio-cognitive niche construction
2 MIN READ
0
Human pheromones, nutrition, DNA, epigenetics
2 MIN READ
0
Human pheromones are like sugar (and spice)
< 1 MIN READ
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Niche construction: ecological, social, neurogenic, and socio-cognitive
2 MIN READ
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Human pheromones in business strategy
< 1 MIN READ
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Human pheromones, social deprivation, and brain growth
< 1 MIN READ
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Human Pheromones and Free Will: a response to Gazzaniga
2 MIN READ
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Flies Evolve to Count (not)
< 1 MIN READ
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Nutrient mixture and memory in patients with early Alzheimer’s
< 1 MIN READ
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Human pheromones and multi-level selection
< 1 MIN READ
0
Bee research, human sweet perception, human pheromones, and metabolic disorders
< 1 MIN READ
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Where is the love?
3 MIN READ
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Human pheromones and the viruses that make us
2 MIN READ
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A detailed model of physical reality and natural selection (722 words)
3 MIN READ
0
Evolution of the nervous system: conserved GnRH
< 1 MIN READ
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Hacking the Genome
< 1 MIN READ
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Human Pheromones and Comparative Epigenomics
2 MIN READ
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Aging Is Recorded in Our Genes
2 MIN READ
0
Human Pheromone Facts and the Out of Africa Theory
3 MIN READ
0
Social decision-making in vertebrates (Part 1)
2 MIN READ
0
ecological social neurogenic niche
2 MIN READ
0
Smelling the difference between young and old
< 1 MIN READ
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Human pheromones and the visual appeal of other people (Part Four)
3 MIN READ
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No New Neurons for Smell?
2 MIN READ
0
Human pheromones: Olfaction, odor receptors, learning, memory, mood, brains and behavior
< 1 MIN READ
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A nutrient chemical and pheromone-dependent neurogenic niche
2 MIN READ
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Passing On Stress
2 MIN READ
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Human pheromone- and nutrient-dependent brain development and behavior
2 MIN READ
0
Human pheromones and the visual appeal of other people (Part Two)
2 MIN READ
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Human Pheromones: The smell of the scientific universe expanding
< 1 MIN READ
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More than speculation: adaptive evolution in species from microbes to man
2 MIN READ
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Human pheromones and your immune system
< 1 MIN READ
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Human Pheromones: extremely technical representation of the concept
2 MIN READ
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Human Pheromones in Socioaffective Neuroscience & Psychology
2 MIN READ
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Pheromones and the “Bruce effect” in wild or domesticated horses and primates
2 MIN READ
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They are what they eat, and so are we
2 MIN READ
0
Exercise Alters Epigenetics
2 MIN READ
0
How memory works
2 MIN READ
0
A Preoccupation With Modesty…
2 MIN READ
0
Pheromones: from microbes to man
< 1 MIN READ
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The biology of behavior: Seeing more clearly
< 1 MIN READ
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Researchers Investigate Epigenetic Patterns In Multiple Conditions
< 1 MIN READ
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Genes not culture drive humans forward (an antithetical approach)
< 1 MIN READ
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Effects of pheromones on menstrual synchrony and a gay man
2 MIN READ
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Did viruses make mammals communicate with pheromones?
2 MIN READ
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Do Pheromones Play a Role in Our Sex Lives: Scientific American
< 1 MIN READ
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The cause of colony collapse could be a message for all of us
< 1 MIN READ
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Human Pheromones: 2010 Powerpoint slides and 2011 poster presentation
2 MIN READ
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Epigentics and the baby connectome
2 MIN READ
0
Cookbook chemistry: food odors and hormones
< 1 MIN READ
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Epigenetics and the connectome
2 MIN READ
0
Human pheromones and food odors
< 1 MIN READ
0
Misrepresentations of biologically based cause and effect:
3 MIN READ
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Pheromones and the Evolution of Drug Resistance
< 1 MIN READ
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Cause and effect in biology
< 1 MIN READ
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Baiting evolutionary psychologists and others who damn religion
3 MIN READ
0
Human pheromones provide clues to personality
< 1 MIN READ
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How pheromones work (in 57 words or more)
< 1 MIN READ
0
The Demise of Guys
< 1 MIN READ
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Pheromones and detectable odors
2 MIN READ
0
Pheromone-enhanced behavior in sexually inexperienced females
2 MIN READ
0
Epigenetic ‘memory’ key to nature versus nurture
< 1 MIN READ
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The “yuck” factor: aversion to social odors?
2 MIN READ
0
Avian ‘Axe effect’ attracts attention of females and males
2 MIN READ
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Study results: Human pheromones affect women’s behavior
< 1 MIN READ
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Human pheromones: social odors and food odors
< 1 MIN READ
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Honeybees, food odors, and perfume
< 1 MIN READ
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Pheromones and a realistic model of sexual differentiation
3 MIN READ
0
Avian recognition of human faces
< 1 MIN READ
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Human Pheromones Affect Women's Behavior
2 MIN READ
0
A lesser role for olfaction and pheromones in humans?
1 MIN READ
0
Creating a Myth
< 1 MIN READ
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Study results: Human pheromones influence human behavior
2 MIN READ
0
Pheromones in birds, other mammals, and us
< 1 MIN READ
0
The great pheromone myth revisited (including biological factors in the development of sexuality)
4 MIN READ
0
The great pheromone myth revisited (including biological factors in the development of sexuality)
4 MIN READ
0
Social selection: genetic contribution of viruses to life on earth
< 1 MIN READ
0
Wikipedia comments by James V. Kohl
5 MIN READ
0
Excellent new book about pheromones
< 1 MIN READ
0
Study design| Psychophysics experiment | Perspective on conditioning
< 1 MIN READ
0
Adrenarche and odor preferences
2 MIN READ
0
For ethologists: Observation does not trump molecular biology
2 MIN READ
0
Human Pheromones and The Philosophy of Science
2 MIN READ
0
Genes, Hormones, and Behavior (for other scientists)
4 MIN READ
0
Love at first sight: Selective breeding, pheromones, and Divine intervention
3 MIN READ
0
A fundamental attribution error: Love at first sight
3 MIN READ
0
Human Pheromones
< 1 MIN READ
0
Pheromones and olfaction in the birds and the bees: from yeasts to you
2 MIN READ
0
Pheromones and Physiology: Faculty of 1000: Naturally Selected
2 MIN READ
0
Debunking the myth of pheromones
< 1 MIN READ
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Tears and fears of pheromones
2 MIN READ
0
Exotic Pheromones and Concentrates
2 MIN READ
0
Marketing vs. the truth about human pheromones
2 MIN READ
0
Molecular biology and social science theory
2 MIN READ
0
Epigenetics, science fiction, and scientific fact
2 MIN READ
0
Results: increased flirtatious behavior and self-reported attraction
2 MIN READ
0
Is it what he or she sees in you, or is it your pheromones?
2 MIN READ
0
Product comparisons and human pheromone sciences
3 MIN READ
0
Conditioning of the human pair bond by human pheromones
< 1 MIN READ
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Conditioned sexual arousal to odor
2 MIN READ
0
Scent signals
< 1 MIN READ
0
Pheromones and signature mixtures
2 MIN READ
0
Comparative biology of pheromonal communication
< 1 MIN READ
1
Food preferences and mate preferences
< 1 MIN READ
0
Presentation on Human Pheromones delivered on August 3, 2010
2 MIN READ
0
Sold on the human VNO?
< 1 MIN READ
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Effects of pheromones attributed to touch (in mice)
< 1 MIN READ
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How pheromones work by James V. Kohl
2 MIN READ
0
Pheromones of pregnant women effect prolactin in men
< 1 MIN READ
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Another book author's comment on "The Great Pheromone Myth"
< 1 MIN READ
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An attempt to change the concept
< 1 MIN READ
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Luteinizing hormone, sex, and smell (18 years later)
2 MIN READ
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