Systems biology and memory disorders

By: James V. Kohl | Published on: September 30, 2014

Reversal of cognitive decline: A novel therapeutic program

Reported as:

Memory loss associated with Alzheimer’s reversed: Small trial succeeds using systems approach to memory disorders

News Article Excerpt:

(1) eliminating all simple carbohydrates, leading to a weight loss of 20 pounds;
(2) eliminating gluten and processed food from her diet, with increased vegetables, fruits, and non-farmed fish;
(3) to reduce stress, she began yoga;
(4) as a second measure to reduce the stress of her job, she began to meditate for 20 minutes twice per day;
(5) she took melatonin each night;
(6) she increased her sleep from 4-5 hours per night to 7-8 hours per night;
(7) she took methylcobalamin each day; ( Methylcobalamin (MeCbl), the activated form of vitamin B12)
(8) she took vitamin D3 each day;
(9) fish oil each day;
(10) CoQ10 each day;
(11) she optimized her oral hygiene using an electric flosser and electric toothbrush;
(12) following discussion with her primary care provider, she reinstated hormone replacement therapy that had been discontinued;
(13) she fasted for a minimum of 12 hours between dinner and breakfast, and for a minimum of three hours between dinner and bedtime;
(14) she exercised for a minimum of 30 minutes, 4-6 days per week.
Seven items are associated with nutrient uptake and five items are associated with stress reduction via exercise and sleep. Hormone replacement — for a total of 13 out of 14 items — also links the epigenetic landscape to the physical landscape of DNA in the organized genomes of all vertebrates via the same neuronal system.
The honeybee model organism can now be linked to epigenetically-effected human health and disease via the conserved molecular mechanisms of RNA-directed DNA methylation and RNA-mediated cell type differentiation. The link is the gonadotropin releasing hormone neuronal (GnRH) system. For example, Feedback loops link odor and pheromone signaling with reproduction via the GnRH neuronal system in mammals.
We linked the nutrient-dependent pheromone-controlled feedback loops across species from microbes to man via the conserved molecular mechanisms of cell type differentiation in our Hormones and Behavior review: From Fertilization to Adult Sexual Behavior.
Elekonich and Robinson (2000) “Organizational and activational effects of hormones on insect behavior” extended hormone-organized and hormone-activated behaviors to invertebrates and Elekonich and Roberts (2005) Honey bees as a model for understanding mechanisms of life history transitions extended our 1996 ‘microbes to man’ model to life history transitions in the honeybee.
In my 2012 review Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors, I noted that: “The honeybee already serves as a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, and diseases of the X chromosome (Honeybee Genome Sequencing Consortium, 2006). Included among these different aspects of eusocial species survival are learning and memory, as well as conditioned responses to sensory stimuli (Maleszka, 2008; Menzel, 1983).”
See: How Do We Answer Fools? Clearly, this new n=10 study, which has not been replicated, shows evolutionary theorists that — if honeybees had teeth — improved oral hygiene might be the most important intervention of all to help them avoid Alzheimer’s disease symptoms. Indeed, the theorists may even link their ideas about the evolution of pheromones to the evolution of teeth in predatory nematodes via mutations and/or natural selection, which they think somehow leads to the evolution of biodiversity.
For contrast, the 14 step intervention shows serious scientists how important it is to link the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man via conserved molecular mechanisms. Attempts to treat pathologies based on the pseudoscientific nonsense of evolutionary theories without considering their basis in nutrient-dependent pheromone-controlled cell type differentiation has led to 18 years of wasted research dollars that could have been better spent developing a model of biologically-based cell type differentiation, which is clearly involved in 13 of the 14 interventions listed above. See also: Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis.

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