An epigenetic mark links algae, worms, and flies

By: James V. Kohl | Published on: May 2, 2015

New Epigenetic Mark Found on Metazoan DNA

Three studies identify roles for N6-methyladenosine in algae, worms, and flies. By Jenny Rood | April 30, 2015

Excerpt (with my emphasis): “In bacteria, 6mA marks the template strand during DNA replication, enabling a cell to spot errors and regulate the cell cycle. The modification also helps differentiate bacterial DNA from viral genomic material, which lacks methylation.”

My comment: The ability of a cell or organism to recognize self vs other differences enables selection of nutrients. Nutrient energy is required for thermodynamic cycles of protein biosynthesis and degradation that lead to organism-level thermoregulation, which prevents genetic entropy. If nutrient-dependent microRNAs did not prevent viruses and viral microRNAs from causing entropic elasticity that leads to genetic entropy, the mutations caused by viruses would not be controlled. Without the control of mutations, epigenesis could not lead to epistasis, which is maintained during life history transitions by nutrient-dependent RNA-directed DNA methylation and RNA-mediated amino acid substitutions that stabilize the organized genomes of all genera.

The sun’s biological energy is linked from the de novo creation of light-induced amino acids, to the anti-entropic epigenetic effects of nutrients and the nutrient-dependent RNA-mediated amino acid substitutions that differentiate all cell types in all organisms. In species from microbes to man, experimental evidence now links N6-methyladenosine to DNA repair and the physiology of nutrient-dependent RNA-mediated metabolic networks and genetic networks.

For contrast, see:

This Is My Vision Of “Life” Richard Dawkins [4.30.15]

Introduction by: John Brockman
Excerpt: “…all the limbs and all the sense organs work together. It’s simply because all the genes that built them have the same exit route to the next generation. The minority that don’t, things like viruses, they have a different exit route, and they don’t cooperate, and they may kill you.”
My comment: If not for RNA-mediated events that link metabolic networks to genetic networks via amino acid substitutions to organism-level thermoregulation, there would be no such thing as a species. Viruses would have killed every living thing. Nutrient-energy prevents virus-driven genetic entropy. It links amino acid substitutions to the biodiversity of morphological phenotypes and behavioral phenotypes via the biophysically constrained chemistry of RNA-mediated protein folding.
Richard Dawkins’ vision of “life” fails to include any experimental evidence that links viruses to the physics, chemistry, and molecular mechanisms of life via communication across species.
See for comparison: The Darwin Code by Greg Bear
Excerpt: “…I tried to assemble the outline of a modern appendix to Darwin, using ideas derived from disciplines not available in Darwin’s time: theories of networks, software design, information transfer and knowledge, and social communication–lots of communication.”
Dawkins and Bear appear to have one thing in common. Their “vision” of biodiversity excludes God. However, they do not include the de novo creation of amino acids or any information on how virus-mediated cell type differentiation occurs.
It occurs via nutrient-dependent amino acid substitutions, which obviously are linked to the de novo creation of amino acids. The question arises: Did God also create the viruses that perturb nutrient-dependent RNA-mediated protein folding and link mutations to pathology? Or, did something go wrong with our ancestor’s food choice, which led them to ingest the viruses that have since been linked to pathology when the viruses are not controlled by nutrient-dependent RNA-mediated amino acid substitutions.

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