MicroRNA-mediated existential threats (7)
MicroRNA Signaling (22 Articles) established the links from MicroRNAs organize intrinsic variation into stem cell states 3/5/20 to MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20.
Ignorant and arrogant theorists responded to the facts with more ignorance and arrogance. A group of them published Cryptic and abundant marine viruses at the evolutionary origins of Earth’s RNA virome 4/7/22
…information on the three-dimensional structures of the RdRp, network-based clusters, other genomic domains, and whole-genome characteristics help reshape the outlines of the evolutionary history of RNA viruses.
On 4/17/22, in MicroRNA-mediated existential threats (1), I cited the nonsense about evolutionary origins. The revision of stupid evolutionary theories was published as a preprint on 4/21/22. Former NIH Director, Francis S. Collins co-authored Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
Large scale genetic analysis previously reported data in the context of expression quantitative trait locus (eQTL) analysis. The data analyses did not link God’s Creation of sunlight and humidity to the microRNAs implicated in diabetes and related traits via quantum physics, protein folding chemistry, and conserved molecular mechanisms across kingdoms.
For comparison, quantum coherence has repeatedly been linked to coherently organized biology via food energy-dependent pheromone-regulated genetic processes of reproduction in species from soil microbes to humans. That fact can now be viewed in the context of microRNA mediated existential threats and Spectroscopy Takes the Long View on Threat Detection.
Over the past five-plus years, the U.S. Department of Defense (DOD) and the Department of Homeland Security (DHS), as well as other government agencies, have been focused on detecting trace residues on surfaces rather than targeting aerosol threats…
One of the instrument’s most recent discoveries came last August with the observation of fluorescence from organics that were co-located with minerals such as olivine and carbonate, suggesting an abiotic formation of organics.
This article helps to explain why the focus changed to detecting trace residues on surfaces. See: Amplification of light within aerosol particles accelerates in-particle photochemistry 4/14/22 The facts were reported as Light amplification accelerates chemical reactions in aerosols
“Current computer models of global atmospheric chemistry don’t yet take this light amplification effect into account,”
Former President Donald J. Trump reported the nonsense linked to current computer models of global atmospheric chemistry on 4/23/20 with the claim that sunlight and humidity weaken COVID-19.
Greg Bear served as a consultant for NASA, the U.S. Army, the State Department, the International Food Protection Association, and Homeland Security on matters ranging from privatizing space to food safety, the frontiers of microbiology and genetics, and biological security. Greg Bear predicted the change of focus to effects of light amplification, viral endemicity and sympatric speciation in Darwin’s Radio (reviewed in 2000) and in Darwin’s Children (reviewed in 2003).
In Quantico, all intelligent serious scientists learned from a science fiction writer that biogenesis cannot occur in the absence of an energy source. Thus, abiogenesis is not a term that is used by intelligent serious scientists. Sunlight and humidity link God’s Creation of the energy source to the end of the pseudoscientific nonsense about abiogenesis via what is known about energy-dependent fluorescence.
The observance of fluorescence links God’s Creation of energy-as-information to protection from the virus-driven degradation of messenger RNA, which links mutations to all pathology.
For comparison, link His separation of equal light and equal dark on Day 4 of Creation in Biblical Genesis via “Bacteria evolve over a weekend” 2/26/15
The weekend evolution of the missing bacterial flagellum occurring in an organism that takes it name from its energy-dependent pheromone-regulated genetic processes of microRNA-mediated fluorescence: P. fluorescens. The resurrected flagella enabled the bacteria to access food supplies, which allowed fixation of two amino acid substitutions.
For the link from the weekend resurrection of the flagella to energy-dependent microRNA-mediated healthy longevity across kingdoms via two amino acid substitutions, see:
Differential expression and sorting of exosomal microRNAs upon activation of the human monocyte-like cell line U937 4/14/22
Exosomal microRNAs of U937 macrophage cells are differentially expressed during activation.
Activation requires an energy source. God Created the energy that links activation to differential expression of genes via microRNAs in exosomes.
Extracellular vesicles such as exosomes in eukaryotes…including microRNAs (miRNAs), are more abundant among the cargo of exosomes than other RNA types. MiRNAs loaded in secreted exosomes (or extracellular microRNAs) can be transported to recipient cells and may play a regulatory role although the miRNA loading (or sorting) mechanism in exosomes….
See also: Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2 4/21/22
…single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation.
Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription.
That fact links Thomas E. Ichim’s patented therapeutic solutions for virus-driven pathology from the microRNA-mediated Creation of stem cells to Alexandria Henrion-Caude’s Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20
The energy-dependent biosynthesis of microRNAs links God’s Creation of sunlight and humidity to pH-dependent healthy longevity across kingdoms via the physiology of reproduction, which biophysically constrains the virus-driven degradation of messenger RNA.
See also McEwen et al., (1964) Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.