The tipping point (revisited): 150K

By: James V. Kohl | Published on: November 24, 2022

Jon Entine called attention to this 11/3/22 article: Biological tipping point: At a certain point in life, environmental factors and age are more important to disease risk than DNA in the context of his Genetic Literacy Project, which exemplifies human idiocy in the context of his focus on stupid theories.

My series of blog posts on the biological-basis of “The Tipping Point” started when there were 87K indexed published articles that linked light-activated miRNA biogenesis to The tipping point (revisited): 87K (2) 5/28/19, and a series that extended this claim “ Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions” to The tipping point (revisited): 135K 2/5/22. This claim extends experimentally established facts to cell type differentiation during every pH-dependent life cycle of every organism on Earth:

…nucleotides within the three base pair mismatches displayed unique structural properties, including varying dynamics and sensitivity to solution pH.

Rather than accept the facts that link the virus-driven degradation of mRNA from pH-dependent changes in base pairs and changes in the miRNA-mRNA balance to fixation of amino acids, or to the virus-driven degradation of mRNA and all pathology, Jon Entine likes the idea of quantifying the effect of eQTLs on gene expression in different age groups. He links aging to gene expression without consideration for the ATP-dependent Creation of nucleic acids.

See: Tissue-specific impacts of aging and genetics on gene expression patterns in humans 10/3/22

There are now more than 150,000 indexed publications that link the energy-dependent Creation of the nucleic acids, RNA and DNA to pH-dependent healthy longevity across kingdoms, or from the virus-driven degradation of mRNA to all pathology.

See also: miRNAs 150,771 results on 11/23/22

Compare the facts that have since linked injections of synthetic mRNAs to pathology (via alterations of the biophysically constrained miRNA/mRNA balance) to Jon Entine’s alignment with the fools who attempted to get this article retracted Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs 4/15/22.

Watch for more examples of human idiocy, which can be expected from him and from other gene-centric theorists who have no scientific integrity whatsoever. See: Scientific Integrity Requires Publishing Rebuttals and Retracting Problematic Papers 10/26/22 No matter how many more indexed published works attest to facts about the ATP-dependent Creation of RNA, stupid theorists will start with theories about DNA as if it Created itself.

See for comparison: mRNA vaccines — a new era in vaccinology 1/12/18 and the predictable dead end of the nonsense about the “new era.” The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis 11/17/22

As soon as you link changes in ATP-dependent miRNA-mRNA balance to healthy longevity, and/or link the virus-driven degradation of mRNA to all pathology, you can help stop the unnecessary suffering and premature deaths caused by gene-centric theorists and their idiot minions who work for Big Pharma.

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