Orchestrated death: Francis S. Collins (2)
See first: Orchestrated death: Francis S. Collins
He had the responsibility to not fund the gain-of-function research that led to the loss of our freedoms in the USA. Instead, he failed to mention anything about microRNAs and the fact that miR-155 regulates both adaptive and innate immune responses.
Moving forward: Exogenous miRNAs induce post-transcriptional gene silencing in plants 10/14/21 was reported on 10/21/21 as Plants Use RNA to Talk to Neighbors
A study finds that plants sharing the same growth medium can exchange microRNAs that silence genes in the recipient, suggesting the nucleic acids may act as signaling molecules.
See also: Growing crops under solar panels? Now there’s a bright idea. 10/14/21
The ‘bright idea’ was to grow crops with sunlight. If you have not yet linked light-activated microRNA biogenesis in plants to biophysically constrained viral latency and healthy longevity in species from cyanobacteria to humans via single nucleotide polymorphisms (SNPs) in microRNAs and the physiology of reproduction, see our section on molecular epigenetics in our review of cell type differentiation via pre-mRNAs in From Fertilization to Adult Sexual Behavior (1996)
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.
When the term precursor-messenger RNA (pre-mRNA) was changed to microRNA, everything known to all intelligent serious scientists about every aspect of energy-dependent biophysically constrained viral latency and healthy longevity began to be obfuscated by neo-Darwinian theorists and conspiracy theorists. More than 187 indexed published works that mention microRNAs were added today.
Now the fact that Exogenous miRNAs induce post-transcriptional gene silencing can be more readily linked across kingdoms from microbes to humans via energy-dependent changes in base pairs that link the exogenous miRNAs from God’s Creation of the potential of hydrogen (pH) to photosynthesis and all biodiversity on Earth via light-activated pH-dependent RNA-mediated changes in base pairs.
See: Nucleic acid
In RNA, base-pair sequencing provides for manufacturing new proteins that determine the frames and parts and most chemical processes of all life forms.
You can now link God’s Creation of sunlight and humidity to all RNA-mediated biophysically constrained changes in nucleic acids, the biomolecules that are essential to all forms of life via the composition of nucleotides, which are made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base.
Neo-Darwinian theorists and their idiot minions, the conspiracy theorists, failed to link Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 to Peptide synthesis at the origin of life 11/13/20.
They ignored the claims that linked God’s Creation of energy as information 5-10,000 years ago to the fact that nucleic acids are naturally occurring chemical compounds, which means they did not automagically create themselves to serve as the primary information-carrying molecules in cells.
Instead, Chakraborty et al., reported that MicroRNAs organize intrinsic variation into stem cell states 3/5/20. That links the nucleic acids from the genetic material in all cell types from God’s Creation of energy to the encoded information known as endogenous RNAs, which are found inside and outside the cell nucleus.
Endogenous RNAs link the ATP-dependent Creation of RNA from the claims of Bruce S. McEwen et al., (1964) to the encoding and storage of information. Nutritional stress and/or social stress link the virus-driven degradation of mRNA to mutations and pathology,
1) Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
…some miRNAs studied could have an antiviral effect, enabling the defense mechanisms to fight the infection or, at the very least, they could induce the pathogen to enter a latent state. At the same time, some viruses encode their own miRNAs, which could further modulate the host’s signaling pathways, thus favoring the survival and replication of the virus.
See also the Research Topic: MicroRNA Signaling (21 additional articles) and more than 129,410 indexed published works that mention microRNAs.
Clearly microRNAs have been linked from the transmission of information to gene expression via the interior operations of endogenous substrates in stem cells and other cells, which ultimately link God’s Creation of sunlight and humidity from light-activated microRNA biogenesis in plants to the first generation and to every subsequent generation of each living organism on Earth during the time frame established in: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 1/10/13
We estimate that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years.
See: The Roles of MicroRNAs in Male Infertility 3/13/21 and any other articles that link natural selection for energy-dependent codon optimality to fixation of amino acid substitutions via protein synthesis in the organized genomes of all male and female individuals in all species on Earth.
Energy constrains the nucleic acid sequence, which provides the well-ordered ‘ladder-step’ organization of nucleotides within the molecules of RNA and DNA. The ATP-dependent Creation of RNA is required to direct the effects of DNA on protein synthesis.
Gene-centric theories touted by Francis S. Collins and others failed to link physics and chemistry from molecular epigenetics to constraints on base pairs, which link energy-dependent bonding of strings of nucleotides to the formation of helical backbones, one for RNA and two for DNA. The hellical backbones link chains of naturally selected base-pairs to Darwin’s “conditions of life” via the five primary, or canonical, nucleobases, which are: adenine, cytosine, guanine, thymine, and uracil.
The creation of amino acids links the genetic processes of protein synthesis to the specific sequencing in DNA of these nucleobase-pairs, which enables storing and transmitting coded instructions as genes.
When stupid theorists start with gene-centric theories they include claims like this one from A universal trend of amino acid gain and loss in protein evolution 2/10/05
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
Their foolishness can be viewed in this context: See: Structural diversity of supercoiled DNA (2015) and the fact that bases do not automagically create themselves