Light-activated chemogenetic kinetics (2)
(click to enlarge)
G-tract RNA removes Polycomb repressive complex 2 from genes 9/23/19
Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates with genes ectopically in cancer.
Conclusion:
These data support a model in which pre-mRNA evicts PRC2 during gene activation and provides the means to selectively remove PRC2 from specific genes.
Reported as: Method discovered to reactivate tumour fighting genes ‘silenced’ by cancer 9/23/19
Healthy cells use PRC2 to silence genes whose instructions should only be read by other cell types. Cancer cells ‘hijack’ this silencing function of PRC2 to switch off ‘tumour suppressor’ genes. When active, these genes stop cells from dividing, so if PRC2 could be removed from these genes it could halt tumour growth.
Using healthy cells grown in the lab, the researchers found that PRC2 also binds to RNA, the information molecule that is produced by active genes. When PRC2 binds RNA, it can no longer bind and silence the gene.
The information molecule , RNA links the light-activated assembly of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and all pathology via what also is called the polycomb repressive complex 2.From Fertilization to Adult Sexual Behavior
Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes…
Others have ignored the evidence that links pre-mRNAs to what is known about how microRNAs (also known as pre-mRNAs) link the Creation of RNA to biophysically constrained viral latency and healthy longevity.Ultrastructural localization of DREADDs in monkeys 5/18/19 the HA-molecule corresponding to amino acids 98-106. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission (2007) via the energy-dependent Creation of the information molecule , RNA.Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions. Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication Enterovirus pathogenesis requires the host methyltransferase SETD3 9/16/19
Our results reveal a crucial role of a host protein in viral pathogenesis, and suggest targeting SETD3 as a potential mechanism for controlling viral infections.
This was reported (with my emphasis ) as: Disabling a single protein could “cure” the common cold
Viruses, like those that cause colds and flu, are some of the fastest-evolving forms of life on Earth. That’s why there are no permanent cures for these common illnesses. Any time scientists come up with a vaccine, it doesn’t affect all strains of the virus and even those that are inhibited by it can evolve resistance to the drug pretty quickly.
Serious scientists do not consider viruses to be evolving life forms. Replication requires them to steal the energy from living cells that is required for biophysically constrained cell type differentiation via the information molecule , RNA and fixation of amino acid substitutions.information molecule , RNA to biophysically constrained viral latency via EDAR V370A in mice and non-human primates.Hi Jessica. Standing on the shoulders of giants may not be a good idea if the giants stepped on the toes of biologically uninformed science idiots who failed to link EDAR V370A from mice to humans in the context of the requirement for biophysically constrained viral latency. Environmental selection…through breast milk.
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations….”
Simply put, the human-specific EDAR V370A allele links the information molecule , RNA to virus-driven vector-induced species differences in exogenous proteins that link the degradation of the information molecule, also known as messenger RNA to food energy-dependent pheromone-controlled ecological adaptations in species from yeasts to mammals. The adaptations are “All about that base”VIDEO Highly Sensitive in Vitro Diagnostic System of Pandemic Influenza A (H1N1) Virus Infection with Specific MicroRNA as a Biomarker 9/10/19information molecule , RNA.
…this CIVD kit has shown excellent detection performance in real intracellular RNA samples and confirmed results similar to those of conventional methods (microarray and quantitative real-time polymerase chain reaction).
See also: Discovery of malleable epigenetic processes in ant brains has implications for the study of human behavior and disease 1/4/16GPCR transgenes can be notoriously difficult to overexpress “correctly”, they often require the addition of signal sequences to get to the cell surface. Feedback loops link odor and pheromone signaling with reproduction
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0
Mechanisms of stress: from genes to cancer
9
0
Viruses come alive: Tree of life pseudoscience
6
0
Theorists have not seen the light (2)
3
0
Hijacked light energy and vertebrate pathology
4
0
Theorists have not seen the light
4
0
Alternative pre-mRNA splicing and ecological adaptation
7
0
Pathology: Eating and breathing viruses
2
0
Exosomes and the RNA-mediated future of medicine
5
0
Somatic hypermutation vs RNA-mediated events
2
0
Phytochemical link from the sun to cell types
2
0
Genome sequencing, cadherins, and quantum consciousness
6
0
“New” quantum biology. Pirating the old
3
0
Cell types, SNVs, CNVs, and chromosomes
3
0
Thermotolerance and Longevity
57
0
Is life the balance between quantum and classical physics?
3
0
Anti-entropic containment of energy: symbiosis 1.0
5
0
Information and communication (2)
6
0
Information and communication
2
0
From “Blood Music” to Evolution 2.0
5
0
Olfaction & the octopus and human genomes
3
0
Thermodynamic constraints did not evolve
3
0
Mammalian-wide interspersed repeats (MIRs)
2
0
Ecological speciation vs revised evolutionary syntheses
6
0
Ecology replaces the extended evolutionary synthesis
4
0
The stability of organized genomes (4)
3
0
The stability of organized genomes (3)
3
0
Epimutation.com: a domain of confusion
8
0
Light -induced nucleic acid-mediated gene duplication?
< 1
0
Viruses, amino acids, and somatic cell types (2)
5
0
RNA-mediated terms of virus-induced en-deer-ment
2
0
Domestication via a single amino acid substitution
2
0
Becoming biologically informed (3)
3
0
Easy editing: Reinventing our RNA world
3
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2
0
Picornaviruses moving between primates (or not)
2
0
Faithfully repaired DNA
5
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6
0
MicroRNA controlled growth and brain development
7
0
MicroRNA – controlled ecological adaptations
5
0
Becoming biologically informed
2
0
Celebrating independence from ridiculous theories
3
0
“New” epigenetic mechanism for lifelong learning?
3
0
The sum of our RNA-mediated parts
2
0
Protein folding and Google page rank
2
0
Iron, ferritin, thyroxine
2
0
Virus-driven death by evolutionary theory
3
0
“Evolution” of sex differences?
2
0
Nutrient stress-induced RNA-mediated pathology
< 1
0
Amino acid substitutions are not mutations
2
0
What I cannot create I eliminate from discussion
3
0
Healthy mutants
2
0
Uniquely epigenomic gene regulation
2
0
Alternative splicings: epigenetics meets pharmacogenomics
4
0
Epigenetic regulation of aging by glycine and GnRH
5
0
Physicians who practice evolutionary medicine?
3
0
Pattern recognition: biogeochemical structure and function
5
0
Viruses and the human-like microbiome
3
0
Informing the biologically uninformed
< 1
0
I forgot. How do mutations cause evolution?
4
0
One amino acid substitution, genes, and brain activity
3
0
Batch effect vs epigenetic effects
3
0
Gene expression, immortality, and cancer
6
0
Scientists lose. A sci-fi author gains credibility
2
0
Vitamin B3 and DNA repair
4
0
Ignoring systems complexity (it’s too complicated)
3
0
Virus-driven cancer treatment and prevention
2
0
The microbiome, pharmacogenetics, and privacy
< 1
0
A special issue on nutritional epigenetics
5
0
Retinoic acid + one receptor regulate the genome
3
0
Epigenetics: microRNAs effect an integrative pathway
4
0
Protein isoforms do not evolve
3
0
Tissue type variation and expression of genes
< 1
0
From gut bacteria to breast milk and back
5
0
Chance mutations — not natural selection
5
0
How to find a “holy grail” under your nose
3
0
Physics, chemistry, light, and life
2
0
MicroRNAs and the exposome
5
0
An epigenetic mark links algae, worms, and flies
2
0
Effect and affect of a single base-pair change
4
0
Thermodynamics and protein folding landscapes
2
0
Feedback loops link insects to human brains
2
0
Viruses and cell type differentiation
3
0
RNA-mediated cell types and precision medicine
5
0
DNA Methylation and organized genomes
7
0
Misunderstanding cancer
7
0
Nutrient-dependent RNA interference (2)
4
0
Mutisensory integration: watching the paradigm shift
12
0
Origin of life and cancer (1,2,3)
2
0
Silencing genes and serious scientists
3
0
The miRNA/mRNA balance: a suboptimal strategy?
2
0
Nutrient-dependent microRNAs control cell types
6
0
Too many targets for theories
3
0
Creating nothing but a theory (3)
4
3
Creating nothing but a theory (2)
4
0
The quantum / classical RNA-mediated ‘tipping point’
3
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4
0
Quantum correlations/pseudoscience
3
0
Anti-entropic solar energy
5
0
Is DNA-directed transcription RNA-mediated?
2
0
RNA directed DNA methylation and cell types
4
0
From 3-D to epigenetically-effected 4-D genome make-up
5
0
Intelligent viruses and cancers?
10
0
Insect homology and diversity attributed to mutations
2
0
Comparing divergent model organisms
2
1
(click to enlarge)