Virus-driven death by evolutionary theory

By: James V. Kohl | Published on: June 25, 2015
Virus-driven death by evolutionary theory(click to enlarge)

Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic

Excerpt:

The data presented here indicates EBOV is able to generate and fix nucleotide and amino acid variation within co-circulating viral lineages on the time-scale of individual outbreaks, including the presence of country-specific lineages, and which may ultimately produce variants with important fitness differences.

Reported as: Three Ebola virus variants identified in Guinea.

Excerpt 1)
The Ebola epidemic has been ongoing in West Africa for over a year, with 27,341 reported cases, of which 11,184 have been fatal[1].

Excerpt 2):

Each variant is defined by a combination of mutations affecting different viral proteins, in particular the VP35 protein, which may be a virulence factor; the virus envelope glycoprotein, which may alter the immune system’s perception of the virus; or the polymerase, which is usually a more conserved viral region.

My comment: Each variant arises via fixation of amino acid substitutions that differentiate the cell types of all genera. The link from viral microRNAs to entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent fixation of amino acid substitutions also links DNA repair to thermodynamic cycles of protein biosynthesis and degradation. The cycles enable nutrient-dependent fixation of the variants in the viruses and organism-level thermoregulation in living organisms.
Theorists who do not know the difference between an amino acid substitution and a mutation may lead to the death of us all before serious scientists and science journalists begin to report on how RNA-mediated cell type differentiation occurs. Currently, most people seem to believe that mutations cause cell type differentiation because they believe in ridiculous theories.
See also: Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak and Identifying Recent Adaptations in Large-Scale Genomic Data
Excerpt 1):

As natural selection can only act on mutations that drive phenotypic variation…

The ridiculous claim that natural selection can only act on mutations that drive phenotypic variation has been repeated often enough to automatically be included in articles that clearly attest to biophysically constrained RNA-mediated links from the epigenetic landscape to the physical landscape of DNA in all genera.  See also:
Excerpt 2)

TLR5 is a well-described Toll-like receptor that plays a crucial role in the immunological clearance of bacterial pathogens. Its ligand, flagellin, is the principal component of the bacterial flagellum and is one of the most abundantly expressed proteins in nearly all flagellated bacteria.

The claim that the bacterial flagellum of one species re-evolved over-the-weekend can be placed into the context of virus-driven ecological adaptations that are nutrient-dependent and pheromone-controlled in species from microbes to man via the conserved molecular mechanisms of RNA-mediated cell type differentiation that have been detailed since the time of our 1996 review: From Fertilization to Adult Sexual Behavior
See also my comments on: Evolution is unpredictable and irreversible, biologists show.
Summary: RNA-mediated cell type differentiation is perfectly predictable. It leads to ecological adaptation or extinction of populations and species.
See also: Scientists pinpoint mutations responsible for ineffective 2014-2015 flu vaccine
Excerpt:

Our studies show that flu viruses recently acquired mutations in critical regions that are recognized by our immune system,” Hensley said. “These new mutations likely contributed to the ineffectiveness of flu vaccines during the 2014-2015 flu season.”

See also: Amino Acid Changes in Hemagglutinin Contribute to the Replication of Oseltamivir-Resistant H1N1 Influenza Viruses 
Mutations perturb protein folding, which is why they are not fixed in the organized genomes of any living species. Amino acid substitutions stabilize the organized genomes of species from microbes to man via nutrient-dependent microRNAs that prevent the genomic entropy caused by viral microRNAs. The amino acid substitutions are fixed in the context of the physiology of reproduction in living organisms and in the context of nutrient-dependent replication in viruses.
That fact links viruses to pathology and nutrients to RNA-mediated health via the biophysically constrained chemistry of nutrient-dependent protein folding in all genera.
Think about that the next time you learn that someone died from a viral infection.
Evolutionary theory killed them as surely as the theorists claim it was a virus that mutated.
See also: Europe’s first humans: what scientists do and don’t know
Excerpt:

No one knows why Neanderthals went extinct soon after humans arrived in Europe. Bar-Yosef, like many scientists, sees humans as an invasive force that occupied Europe’s prime land, pushing Neanderthals into more marginal regions such as the Iberian Peninsula. But researchers have blamed the demise of Neanderthals on climate, disease and even domestic dogs.

My comments: Serious scientists know that modern human populations are among the other populations of ecologically adapted organisms. They know that viral microRNAs wiped out the Neanderthals who could not acquire the nutrient-dependent microRNAs that link entropic elasticity to the anti-entropic effects of nutrients on the biophysically constrained chemistry of protein folding in all genera via the physiology of their reproduction.
See also: How to build a Neanderthal
Excerpt:

Epigenetic maps help to explain how archaic humans differed from modern ones despite having very similar DNA sequences.

My comment: RNA-mediated events link the epigenetic landscape to nutrient-dependent amino acid substitutions; organism-level thermoregulation; and to species survival via thermodynamic cycles of biophysically constrained protein biosynthesis and degradation.

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RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (5)
2 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (2)
< 1 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
MicroRNAs vs Red Queen hypothesis
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Positive feedback loops and epigenetic traps
2 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Too complex for the Complex Biological Systems Alliance
4 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Unraveling the secrets of RNA-mediated events
2 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
Neo-Darwinian logic is nonsense
3 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs model
2 MIN READ
0
Epigenetic inheritance of stress-perturbed protein folding
2 MIN READ
0
Xist-ing on planet Earth
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Cancer: forward and reverse
2 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Keep the gay gene theory?
< 1 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Non-mainstream scientist shares Nobel prize in Medicine
3 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Do young neurons in the brain evolve?
< 1 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
New anti-entropic microbes
3 MIN READ
0
Metabolic competition and cancer
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Information and communication
2 MIN READ
0
Unraveling evolutionary pseudoscience
2 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes (2)
4 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Thermodynamic constraints did not evolve
3 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
The stability of organized genomes
5 MIN READ
0
ASCP MLS certification
< 1 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed
2 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
microRNAs and memory: Why trust a theory?
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
MicroRNAs and inappropriate functions
2 MIN READ
0
30 years of theoretical nonsense
3 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Targeting theories to fight disease
2 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
MicroRNAs and the exposome (2)
< 1 MIN READ
0
Finding odor and taste receptors everywhere
6 MIN READ
0
Epigenetics vs the fossil record
4 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Pathology constrains X-linked evolution
2 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
DNA molecules do not arrange themselves.
< 1 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
Genetic chimerism and ecological adaptation
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Life: conserved ion and amino acid transporters
3 MIN READ
0
Graphic misrepresentations of ecological adaptation
2 MIN READ
0
Too many targets for theories
3 MIN READ
0
Methylation maintains cell type differences (2)
2 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic effects of soil bacteria on plants
< 1 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Virus-driven origin of life
2 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
Walk towards the light
< 1 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Imagining that data historically supports evolutionary theory
7 MIN READ
0
Atheism: Arrogant, useless, and divisive ignorance
7 MIN READ
0
The anti-entropic force of "Nature"
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
Military combat training to fight disease
3 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis (2)
2 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Sneaking up from behind
4 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
The future of physics predicts no future for evolutionary theory
3 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Nutrient-dependent cooperation vs cannibalism (video)
2 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
Chromosomal rearrangements and ecological adaptations
4 MIN READ
0
The wrong picture of our evolution
4 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Alternative splicings (very technical)
2 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Seeds of life: astrobiological theory and mutations theory
3 MIN READ
0
Functional coding variants are not mutations
2 MIN READ
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Random mutations: nothing adaptive in 3 billion years
< 1 MIN READ
0
A “new” view of evolution sans mutations
< 1 MIN READ
0
Adaptive evolution: Genetic selection against some disorders
3 MIN READ
0
Constraints on mutational drift
< 1 MIN READ
0
Random mutations theory and pervasive mosaic evolution (the brain)
2 MIN READ
0
Random mutations theory and pervasive mosaic evolution (the body)
2 MIN READ
0
Epigenetic effects on chromatin and regulatation of gene expression (in Archaea?)
2 MIN READ
0
The genetics myth meets the great pheromone myth
2 MIN READ
0
A key mutational event? That’s not very likely.
3 MIN READ
0
Creation vs Evolution: Expression of a newly found gene
2 MIN READ
0
More complicated than 1-2-3
2 MIN READ
0
Docosahexaenoic acid vs. creative use of mutations in natural selection
3 MIN READ
0
Biological facts constrain proponents of random mutations theory
2 MIN READ
0
Pre-existing genetic variability or random mutations: a matter of priorities and choices
2 MIN READ
0
Creation vs Evolution? Pre-existing genetic variation, not random mutation
2 MIN READ
0