Virus-driven downsizing of the human brain (6)
(click to enlarge)
See first: Virus-driven downsizing of the human brain (5)
Scientists may need to seriously reconsider the cast-aside hypothesis that pathogens can play a part in diseases such as Alzheimer’s and Parkinson’s. 3/1/19
“Viruses are often ignored in relation to neurodegenerative diseases,” Yale University neurobiologist Anthony van den Pol tells The Scientist. “That’s in part because there’s no clear sign that a virus causes a neurodegenerative disease. But it might.”
Some viruses can enter the body through the nose and mouth and move to the brain by replicating and spreading through the olfactory bulbs; the lingual nerve, which runs down the jawline and into the tongue; or the vagus nerve, which travels through the neck and thorax to the stomach.
Understanding how infections trigger the immune system, for example, could lead to ways to downregulate glia-driven inflammation in hopes of preventing long-term damage, he suggests.
The facts about how the virus-driven degradation of messenger RNA links neurodegenerative diseases to cancer have been known to all serious scientists since the time researchers discovered the so-called “death gene.” A friend mentioned that this discovery was not publicized when it was first made during the early 1990s by researchers at Harvard and MIT.
I could not verify that claim, but it took less than 5 minutes to find this report:
Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
Together, these results provide an in-depth analysis of miRNA dysregulation in glioblastoma and demonstrate the potential utility of these data in the design of miRNA-regulated therapies for the treatment of brain cancers.
The forthcoming treatment for all cancers was subsequently reported as A cure for cancer? Israeli scientists say they think they found one (1/28/19)
It became readily apparent that skeptics were terrified by these claims from: Israeli company that claims cure for cancer would face years of testing ahead for US market — even if it works (1/29/19)
Accelerated Evolution Biotechnologies (AEBi) claims to use peptides, a chain of amino acids, to target and kill cancer cells.
The company told the Jerusalem Post it will develop a cancer cure “within a year’s time” — but the company has only tested the treatment in mice so far.
An AEBi spokesman acknowledged in an email to CNBC that “complete cure for cancer meaning that we will have the complete solution ready for first tryout in humans.”
The claims were decried in Experts Decry Israeli Team’s Claims That They Have Found The Cure For Cancer (1/30/19)
My claims that the virus-driven degradation of messenger RNA caused all pathology had already been attacked and an anonymous participant in a “Reddit” discussion.
See: Who the heck is James V. Kohl?
CraniumKart
Hi, I came across this post because I had an interaction with this James V. Kohl while back on fb. To my worse juddgement, he kind of got me riled up and I said some rather stern words at him but otherwise innocuous things I called him out on. After searching myself on google, I see my name appears in his blog! He posted a couple things I allegedly said , claiming it is me along with my place of work from my fb profile so that they would come up together in a search. Also, he writes something about my comments towards him occuring on the day of the march for science which is neither here nor there. They don’t reveal anything to really worry about other than me accusing him of being a quack to make it look like I am trying to discredit him, a respectable scientist and that is not something someone at the Institute I work at would do to another scientist . He tries to play off everything with his seemingly impressive internet resume and has somehow, published his drivel somewhere, which appears on pubmed searches and uses that to legitimize himself. Go with your better judgment and do not engage with this individual. I am not surprised at all he has become a topic in reddit leading other burgeoning scientists towards confusion, but I see in all your comments your intincts on this guy are aligned, or the question of who he is would not have created this thread.
Anyone who participated in the so-called March for Science nonsense and referred to me as a quack while employed by an institute for the study of longevity should stay quiet.
Instead, see: Received via form submission from: rna-mediated.com/contact
3/2/19 I am imploring you to remove the tag of my name and institute from your website. You have no right to post misinformation about me in association with the ________ Institute. You can be assured my lawyer will contact you if you do not address this in a timely manner. You are not fooling anyone, and if you don’t want a legal battle on your hands I’d comply swiftly. You won’t win. You can keep your opinions on this as is but you had better respect my request.
3/2/19 Who gave you permission to post searchable misleading commentary on my client ________? You are being warned to remove this effective immediately.
The unnamed antagonist and his so-called attorney gave no details about what misleading commentary I was accused of posting. However, the antagonist works as a researcher on aging.
I’ve been presenting my research on aging since the early 1990s and my presentations include these two, which were made during Anti-Aging Medicine conferences in Las Vegas, Nevada.
1) 2nd Annual Conference on Anti-aging Medicine & Biomedical Technology for the year 2010
Olfactory-hormonal relationships in learning, memory, aging, and behavior (1994)
The early prenatal migration of gonadotropin releasing hormone (GnRH) neurosecretory neurons appears to enable a neuroendocrine sequence of events that allows human pheromones to influence postnatal GnRH secretion, maturation of the hypothalamic-pituitary-gonadal axis; and, in part, the hypothalamic-pituitary-adrenal axis; hormone-dependent synaptogenesis and synaptolysis; neurotransmission; learning; memory; and behavior. That GnRH regulates the collective neural output manifest in reproductive behavior seems consistent with effects of drug therapies that influence the GnRH pulse, and which are used to treat disorders of neuroendocrine and reproductive maturation as well as dysfunctional behaviors. Is the hypothalamic GnRH pulse generator both the biologic and the psychologic core of mammalian reproduction? What is the contribution of extrahypothalamic GnRH? Is there a lack of “hard” scientific evidence for relationships between biologically relevant odors, olfaction, aging, and human behavior?
In 1995, I published Scent of Eros with co-author Robert T. Francoeur and presented more detailed findings during:
2) 3rd Annual Conference on Anti-aging Medicine & Biomedical Technology for the year 2010
Olfactory-genetic-neuronal-hormonal reciprocity in learning, memory, behavior and in immune function. (1995)
A five-step pathway allowing the social environment (“nurture”) to influence the genetic substrates (“nature”) of mammalian behavior is: gene->cell->tissue->organ->organ system. Though there are many environmental influences on the first step of this pathway, odors are the only known social-environmental stimuli that appear to activate gene expression in neurosecretory cells of tissue in the brain an organ that is essential to any organ system involved in learning, memory, and behavior. Olfaction appears to influence learning, memory, and behavior. Thus, the production and distribution of human odors may link two aspects of our social environment (e.g., olfaction and odors) to the genetic substrates of our behavior through a five-step pathway common to many other vertebrates. Olfactory input influences the gonadotropin-releasing hormone (GnRH)-directed regulation of gonadal and adrenal steroidogenesis. Thus, olfactory deficits associated with aging may be linked to a need for hormone replacement therapy, including dehydroepiandrosterone (DHEA). Similarly, olfactory deficits may be linked to immune system function. Many other hormones/neurotransmitters (e.g., melatonin and dopamine) feed back on the GnRH neuronal pathway. This pathway appears to be both the biological and the psychological core of mammalian, including human, behavior. Thus, the influence of odors and olfaction on levels of hormones, including neurotransmitters, may be linked to age-related changes in learning, memory, behavior, and immune system function.
The central focus of my life’s works has been the levels of biological organization that are required to link the creation of the sense of smell from subatomic particles to cytosis and healthy longevity as detailed for ages 10+ in the context of two games: Subatomic: An Atom-Building Board Game and Cytosis: A Cell Biology Board Game.
Antagonists who think I have misrepresented their positions, for comparison, should be more specific. Most of the time I’m not sure what they are complaining about. But see:
One crank dies, another rises to take his place 1/6/14
Here is a sample of JVK’s posting.
Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction.
The attack on my scientific credibility by the biologically uninformed science idiot PZ Myers has been cited many times in attacks by others such as his idiot minions. They refuse to learn anything about biophysically constrained cell type differentiation and can do nothing else but reassert their ignorance.
In this case, the attack by PZ Myers and his idiot minions ended when he banned me — after I provided experimental evidence that chromosomal rearrangements in white-throated sparrows were responsible for food energy-dependent pheromone-controlled biodiversity in two behavioral morphs.
See: Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes
Two fixed differences among 597 amino acids drive a Val73Ile and Ala552Thr (valine to alanine) polymorphism in ZAL2m that distinguish its morphological and behavioral phenotype from ZAL2.
PZ Myers insulted the intelligence of all serious scientist with his denigration of the works of John A Davison:
He had a “scientific” theory, which was his, which he thought explained all that evolutionary change while refuting those silly scientists who believed that mutations occurred. No! Evolution was all due to chromosome rearrangements, which somehow are not mutations, and he also somehow ignored the existence of allelic differences between species:
The light-activated assembly of the microRNA-RNA-peptide nanocomplex links the physiology of reproduction to biophyically constrained allelic differences between all species via fixation of amino acid substitutions and chromosomal rearrangements.
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MicroRNAs and/or QTLs: Who buried what?
2 MIN READ
0
Molecular Diagnostics: What is unprotected life (4)
2 MIN READ
0
Genome-gate: Follow the money?
4 MIN READ
0
Creating nutrient-dependent life with enough genes to survive
3 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
Energy-dependent purpose vs teleophobic telorexia
12 MIN READ
0
Stress-linked population-level history dependence
5 MIN READ
0
Do not miss the misrepresentations
2 MIN READ
0
Energy dependent RNA-mediated immunity (5)
4 MIN READ
0
Energy dependent RNA-mediated immunity (4)
6 MIN READ
0
Energy dependent RNA-mediated immunity (2)
10 MIN READ
0
Science vs semantics
4 MIN READ
0
Bacteria see the light and they adapt (2)
5 MIN READ
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3 MIN READ
0
Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (7)
5 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
Will modern human populations adapt to the Zika virus?
5 MIN READ
0
The unoffically uninvited
3 MIN READ
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
MicroRNAs vs Red Queen hypothesis
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Unraveling the secrets of RNA-mediated events
2 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Biophysically constrained or unconstrained?
2 MIN READ
0
Mutated mitochondrial genes vs Supercoiled DNA
2 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Non-mainstream scientist shares Nobel prize in Medicine
3 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Theorists have not seen the light (2)
3 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
Information and communication (2)
6 MIN READ
0
Information and communication
2 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Thermodynamic constraints did not evolve
3 MIN READ
0
Mammalian-wide interspersed repeats (MIRs)
2 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Light -induced nucleic acid-mediated gene duplication?
< 1 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
RNA-mediated terms of virus-induced en-deer-ment
2 MIN READ
0
Domestication via a single amino acid substitution
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
Faithfully repaired DNA
5 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed
2 MIN READ
0
Celebrating independence from ridiculous theories
3 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
Virus-driven death by evolutionary theory
3 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
Nutrient stress-induced RNA-mediated pathology
< 1 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
What I cannot create I eliminate from discussion
3 MIN READ
0
Healthy mutants
2 MIN READ
0
Uniquely epigenomic gene regulation
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Physicians who practice evolutionary medicine?
3 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
One amino acid substitution, genes, and brain activity
3 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
The microbiome, pharmacogenetics, and privacy
< 1 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Viruses and cell type differentiation
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Nutrient-dependent RNA interference (2)
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Origin of life and cancer (1,2,3)
2 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory (3)
4 MIN READ
3
Creating nothing but a theory (2)
4 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
