The tipping point (revisited): 96K (6)

By: James V. Kohl | Published on: January 2, 2020

If you have not yet linked light-activated energy-dependent pheromone-controlled feedback loops to biophysically constrained viral latency and healthy longevity via the physiology of reproduction in species from microbes to mammals, you are biologically uninformed and you may be a pseudoscientist.
Intelligent serious scientists will continue to follow the extant literature and eliminate all the pseudoscientific nonsense touted by neo-Darwinian theorists and Big Bang cosmologists. See for examples: microRNA Items: 1 to 20 of 96005
The extant literture now includes:  Silencing of long non-coding RNA MALAT1 suppresses inflammation in septic mice: role of microRNA-23a in the down-regulation of MCEMP1 expression 1/1/20

…we investigated the effects of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on inflammation in septic mice and the potential mechanisms of the MALAT1/microRNA-23a (miR-23a)/MCEMP1 axis.

They investigated epigenetic effects on the light-activated assembly of the biophysically constrained microRNA-RNA-peptide nanocomplex, but failed to link the pheromone-controlled physiology of reproduction in bacteria to the prevention of sepsis.
See for comparison: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] 8/1/94

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

Interorganism systems of genetic regulation have since been linked from nutrient-dependent pheromone-controlled biophysically constrained viral latency to all biodiversity on Earth via the physiology of reproduction in species from microbes to mammals and sympatric speciation.
See: A Novel Cluster-Based Computational Method to Identify miRNA Regulatory Modules 4/10/18

By integrating miRNA/mRNA expression profiles and sequence-based predicted target site information, we develop a novel cluster-based computational method named CoModule for identifying miRNA regulatory modules (MRMs). The ultimate goal of CoModule is to detect the MRMs, in which the miRNAs in each module are expected to present cooperative mechanisms in regulating their targets mRNAs.

See for comparison: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.

See also: Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma 12/30/19

We identified ten prognosis-related microRNAs, including seven risky factors (hsa-miR-197, hsa-miR-32, hsa-miR-887, hsa-miR-3199-2, hsa-miR-4999, hsa-miR-561, hsa-miR-210) and three protective factors (hsa-miR-3917, hsa-miR-3189, hsa-miR-6854).

See also: Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer (Jan 2020)

The miR-449a level in tumor tissue might be useful as a prognostic indicator for patients with gastric cancer and miR-449a in serum appears to reflect its expression in tumor tissue.

See also: Metformin Inhibits Proliferation and Tumor Growth of QGP-1 Pancreatic Neuroendocrine Tumor Cells by Inducing Cell Cycle Arrest and Apoptosis (Jan 2020)

our study demonstrated the therapeutic potential of metformin and provides molecular mechanistic insights into its anti-tumoral effect on pNETs. This study is the first one describing anti-tumoral effects in pNETs.

See for comparison: Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells 10/17/18
For context, see: Naturally occurring anti-cancer agents targeting EZH2 3/23/17

The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase unit of polycomb repressor complexes such as PRC2 complex that has oncogenic roles through interference with growth and metastatic potential. Several agents targeting EZH2 has been discovered but they often induce side effects in clinical trials. Recently, EZH2 has emerged as a potential target of natural products with documented anti-cancer effects and this discloses a new scenario for the development of EZH2 inhibitory strategies with agents with low cytotoxic detrimental effects… several natural products such as curcumin, triptolide, ursolic acid, sulforaphane, davidiin, tanshindiols, gambogic acid, berberine and Alcea rosea have been shown to serve as EZH2 modulators.

The facts about naturally occurring cancer prevention caused researchers from Iran to ask: Why have microRNA biomarkers not been translated from bench to clinic? 1/17/19
At the end of 2019, that question led to this approach to Precision Medicine.
Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs‘ World 12/27/19
See for comparison:

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.
See also: Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion 12/27/19

…a cardiomyocyte-specific miRNA, transferred to fibroblasts in form of exosomal cargo, is crucial in the activation of myofibroblasts.

Nickel-phosphate pompon flowers nanostructured network enables the sensitive detection of microRNA 10/31/19

To the extent of our knowledge, this is the first report on trace level detection of miRNAs employing non-noble Ni metal nanostructures based biosensing platform.

Ultrasensitive detection of microRNA-21 based on electrophoresis assisted cascade chemiluminescence signal amplification for the identification of cancer cells 10/26/19

This method has been applied for the detection of microRNA-21 in cell lysate, which show that there were significant differences of miR-21 among different types of cells, and the content in cancer cells was much higher than that in normal cells, which can be used for the identification of cancer cells.

See for comparison: Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18  Proof of concept

The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis).

Biologically uninformed theorists, also known as libtards, have retarded the fast-paced scientific progress that led to the patented effective treatment and/or cures for all cancers.  The theorists/libtards have continued to cause unnecessary suffering and premature death, despite the claims from 1964 in:
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Do not blame serious scientists for the failure to prevent or effectively treat all ATP-dependent microRNA-mediated pathology.  Blame the profiteers and biologically uninformed theorists who failed to examine virus-driven pathology in the context of this patent.
RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

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