Predictable idiosyncratic evolved convergence
(click to enlarge)
Predictable convergence in hemoglobin function has unpredictable molecular underpinnings
Excerpt:
…predictable changes in biochemical phenotype do not have a predictable molecular basis.
My comment: Biochemical phenotypes are predicted at every level of examination that starts with hydrogen-atom energy transfer in DNA base pairs in solution, and at least two of these authors know that.
See: Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin June 14, 2013
Excerpt:
Fig. 2 Difference in the network of hydrogen bonds between high- and low-altitude Hb variants, HH-H and LL-L, respectively.
See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model June 14, 2013
See: Mutation-Driven Evolution June 14, 2013
See for comparison: Nothing in Biology Makes Any Sense Except in the Light of Evolution (1973)
Excerpt:
…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla (p. 127).”
See for comparison: New evolutionary finding: Species take different genetic paths to reach same trait
Excerpt:
It turns out that natural selection, a primary evolutionary process, can dependably produce similar, beneficial traits in different species. But at the molecular level, the evolutionary changes tend to be highly idiosyncratic, and are therefore far less predictable.
Excerpt:
“This is a new phenomenon that our findings have helped reveal,” Storz said. His team continues to explore historical influences on genetic adaptation.
My comment: Natural selection for energy-dependent codon optimality is a conserved process of polycombic ecological adaptation that links angstroms to ecosystems via hydrogen atom transfer in DNA base pairs in solution, autophagy, and the physiology of pheromone-controlled reproduction in species from microbes to mammals. The fact that Dobzhansky put natural selection for energy-dependent amino acid substitutions in the alpha chains of hemoglobin that differentiate primate species is removed from consideration in the context of this New evolutionary finding.
For comparison see: Updates of the HbVar database of human hemoglobin variants and thalassemia mutations
Excerpt:
Hemoglobinopathies are the commonest single-gene genetic disorders in humans, resulting from pathogenic genome variants in the human α-like and β-like globin gene clusters (reviewed in 1). Single nucleotide substitutions or indels [INsertions/DELetionS] can lead to several hemoglobin variants owing to amino acid replacements, while molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes can minimally or drastically reduce their expression, leading to α-, β- or δ-thalassemia, respectively.
My comment: Given the number of hemoglobin variants among different populations of primates and ~1260 among different human populations, the claim that Predictable convergence in hemoglobin function has unpredictable molecular underpinnings represents the claim of those who are biologically uninformed, or those who are trying to hide facts about cell type differentiation that have been known to serious scientists since the time the Thomas Hunt Morgan won the 1933 Nobel Prize in Physiology or Medicine.
He linked chromosomes to transgenerational epigenetic inheritance of morphological and behavioral phenotypes before anyone knew what was required to link transgenerational epigenetic inheritance to all biodiversity via the physiology of reproduction.
See also: Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes
Excerpt:
…our results illustrate a detailed chain of events linking a chromosomal rearrangement to changes in overt social behavior.
New evolutionary finding: Species take different genetic paths to reach same trait (revisited)
Excerpt:
“This is a new phenomenon that our findings have helped reveal,” Storz said. His team continues to explore historical influences on genetic adaptation.
My comment: It is not a new finding and they have revealed nothing. They have tried to put accurate representations of nutrient energy-dependent biologically-based cause and effect back into the ridiculous theories of evolution without considering the fact that the energy-dependent physiology of reproduction is controlled by pheromones in species from microbes to mammals. The nutrient-dependent RNA-mediated pheromone-controlled physiology of reproduction is the link from autophagy to fixation of amino acid substitutions in supercoiled DNA that link chromosomal rearrangements to viral latency in all cell types of all living genera.
See also: Search Results for ‘hemoglobin’
For example: From “Blood Music” to Evolution 2.0
See also: Pitfalls of analysis of circulating miRNA: role of hematocrit
Excerpt:
…erythrocytes are carriers of miRNA.
My comment: How else could nutrient energy-dependent RNA-mediated amino acid substitutions be linked from hemoglobin variants to all cell type differences in all birds and in all primates?
See also: Genome divergence and diversification within a geographic mosaic of coevolution
Abstract conclusion:
Our results further characterize a striking example of coevolution driving speciation within perhaps as little as 6000 years.
Excerpt from the conclusion:
Coevolution has often been invoked to explain patterns of macroevolutionary diversification (Ehrlich & Raven 1964; Thompson 2005; Jablonski 2008), and some components of coevolution have been documented in numerous natural populations (Thompson 1994, 2005). However, clear examples of reciprocal selection and adaptation driving speciation (the link between coevolution as a micro- and macroevolutionary process) are largely lacking (Althoff et al. 2014; Hembry et al. 2014).
My comment: The fact that “…clear examples of reciprocal selection and adaptation driving speciation (the link between coevolution as a micro- and macroevolutionary process) are largely lacking…” has not stopped Peter Berean or others like him from claiming that I must change the claims from my model to say that virus-driven energy theft causes some pathology, but not all pathology.
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Metabolic Phenotyping Research
2 MIN READ
0
De novo gene creation: Ignoring the experimental evidence
7 MIN READ
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4 MIN READ
0
Energy-dependent purifying selection / autophagy (3)
2 MIN READ
0
Energy-dependent purifying selection / autophagy
2 MIN READ
0
Optogenetics: Let there be virucidal light!
2 MIN READ
0
Building delicious base pairs in class. It’s elementary Watson and Crick
3 MIN READ
0
Building delicious base pairs in class. It's elementary Watson and Crick
3 MIN READ
0
Energy-dependent maternal-to-zygotic transition
6 MIN READ
1
Virus-driven mutation or amino acid substitution
5 MIN READ
0
Epigenetically effected energy-dependent fluorescence (2)
6 MIN READ
0
Epigenetically effected energy-dependent fluorescence
5 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (7)
3 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (5)
2 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (3)
< 1 MIN READ
0
From Precis to Proof in 6000 years (3)
2 MIN READ
0
From precis to pre-mRNA and proof of concept in F1, F2, F3
6 MIN READ
0
Polycombic ecological adaptation as a science, not a theory (2)
12 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
Biological evolution as a philosophy, not a science
6 MIN READ
0
Attacking Young Earth Creationists
5 MIN READ
0
Olfactory receptor pseudo-pseudogenes
2 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
Energy-dependent polycombic ecological adaptation
21 MIN READ
0
Did evolution autophosphorylate your kinases? (3)
2 MIN READ
1
The human virome (revisited)
4 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Pheromone-controlled autophagy
4 MIN READ
0
Hecatombic evolution VS polycombic ecological adaptation
3 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Nutrient-dependent pheromone-controlled autophagy (2)
6 MIN READ
0
Asking the right questions (2)
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
Hypothesis free pseudoscience vs facts (4)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
The last RNA-mediated theory killer
< 1 MIN READ
0
Base pairs, olfaction and RNA thermometers
4 MIN READ
0
Chromatin: The structure of DNA (2)
8 MIN READ
0
Chromatin: The structure of DNA (3)
4 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
DNA repair via junk DNA (1)
5 MIN READ
0
Unconstrained mutations, Zika virus, Kallmann’s syndrome
4 MIN READ
0
Protecting 4 billion people from virus-driven entropy
< 1 MIN READ
0
Antithetical conclusions (5)
4 MIN READ
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4 MIN READ
0
Energy-dependent natural fluorescence and bioluminescence
2 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity (3)
< 1 MIN READ
0
Biophysically constrained cell type differentiation
3 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity (2)
19 MIN READ
0
RNA-mediated programming of E.coli
< 1 MIN READ
0
Did “Nature” kill Steve Jobs? (2)
6 MIN READ
0
Virus-driven downsizing of the human brain (2)
< 1 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
Major transition ends use of silly theories
5 MIN READ
0
Model vs theory: Progress report!
8 MIN READ
0
The Mind’s Eyes (revisited)
10 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
RNA methylation, behavior, and disease
6 MIN READ
0
Modelling life scientifically: RNA-mediated events
12 MIN READ
0
Energy-dependent RNA methylation (8)
4 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (2)
5 MIN READ
0
Energy-dependent biodiversity
5 MIN READ
0
Countdown to Genetics and Genomics
< 1 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
0
Wasted Templeton Funding (4)
3 MIN READ
0
Magic, Miracle, or Molecular Mechanism?
10 MIN READ
0
Creating and/or programming the immune system
< 1 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Jay R. Feierman: twenty years of antagonism
5 MIN READ
0
Energy dependent RNA-mediated immunity (5)
4 MIN READ
0
Energy dependent RNA-mediated immunity (4)
6 MIN READ
0
Energy-dependent RNA-mediated immunity (1)
10 MIN READ
0
Science vs semantics
4 MIN READ
0
Bringing RNA back to epigenetics (20 years later)
11 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (7)
5 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
Cancer: Evolution 2.0’s Blind Spot
13 MIN READ
0
Despicable fools?
4 MIN READ
0
The radical pair mechanism of ecological speciation
3 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (4)
4 MIN READ
0
Blood test links atoms to ecosystems
2 MIN READ
0
Another failed rescue attempt
5 MIN READ
0
Teleophobes vs teleophiles: a recent history
2 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
RNA-mediated theory killers (3)
7 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Plasma created by sunlight and RNA–mediated epigenetic heredity
2 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Models are not theories (2)
2 MIN READ
0
Fossils vs cell types and the brain
3 MIN READ
0
Designing, engineering, and protecting biodiversity
3 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
Neo-Darwinian logic is nonsense
3 MIN READ
0
700 million years of evolution?
5 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Epigenetic inheritance of stress-perturbed protein folding
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
A 5-10K comparison of design principles to evolution
3 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
From fertilization to RNA-mediated events and back
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
New anti-entropic microbes
3 MIN READ
0
Natural selection: an anti-entropic force?
2 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Unraveling evolutionary pseudoscience
2 MIN READ
0
Eibi Nevo gets it wrong
3 MIN READ
0
From “Blood Music” to Evolution 2.0
5 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
The stability of organized genomes (2)
5 MIN READ
0
Epimutation.com: a domain of confusion
8 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Big Bang Cosmology vs Reality
< 1 MIN READ
0
RNA-mediated morphological AND behavioral phenotypes
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Decreased phenotypic variation: Faith in Facts
7 MIN READ
1
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed
2 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
Amino acid substitutions are not mutations
2 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Gene expression, immortality, and cancer
6 MIN READ
0
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Bees and primates automagically evolve
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
Chance mutations — not natural selection
5 MIN READ
0
Physics, chemistry, light, and life
2 MIN READ
0
An epigenetic mark links algae, worms, and flies
2 MIN READ
0
Pathology constrains X-linked evolution
2 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
MicroRNAs and invasive phenotypes
< 1 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Deeply ingrained thoughts
< 1 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease
3 MIN READ
0
Theoretical physics and molecular biology
5 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Sneaking up from behind (2)
3 MIN READ
0
All of "like kind" in the (bigger) family
6 MIN READ
1
Environment epigenetically shapes the immune system
3 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
Removing natural selection; reshaping the horse; adjusting evolutionary theory
4 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
The key to science: experimental evidence
5 MIN READ
0
Ecological adaptations reported as evolution in insects and mammals
4 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
ALPHA GENOMIX
7 MIN READ
2
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
Evolutionary theorists and evolutionary theists live under rocks
< 1 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
2014 and 2004 Nobel Prize in Medicine
3 MIN READ
0
RNA-mediated genetic engineering (Part 2)
3 MIN READ
0
RNA-mediated events are not a matter of faith
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Unassailable evidence vs assumptions
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Mathematical model: microRNA and epigenetic regulation
2 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
Quantum physics meets Evolutionary Psychology News
2 MIN READ
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4 MIN READ
0
Insect homology and diversity attributed to mutations
2 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
Targeting a cancer gene
2 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Natural selection and the behavior of whole organisms
< 1 MIN READ
0
Natural selection: New insights are unlikely
< 1 MIN READ
0
Human pheromones and IQ via neurogenic and socio-cognitive niche construction
2 MIN READ
0
Human pheromones, nutrition, DNA, epigenetics
2 MIN READ
0
